業績集

2016
Disease-associated glycans on cell surface proteins.
Takahashi M, Kizuka Y, Ohtsubo K, Gu J, Taniguchi N.
Mol Aspects Med. 16, 30021-8 2016
N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4.
Hang, Q., Isaji, T., Hou, S., Zhou, Y., Fukuda, T. and Gu, J.
Sci. Rep. srep33507, 2016
The importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation.
Hou, S., Hang, Q., Isaji, T., Lu, J., Fukuda, T. and Gu, J.
FASEB J. in press, 2016
Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells.
Hou, S., Isaji, T., Hang, Q., Im, S., Fukuda, T. and Gu, J.
Sci. Rep. 6, 18430;DOI: 10.1038/srep18430, 2016
Expression of N-acetylglucosaminyltransferase III suppresses α2,3 sialylation and its distinctive functions in cell migration are attributed to α2,6 sialylation levels.
Lu J., Isaji T., Im S., Fukuda T., Kameyama A. and Gu J.
J. Biol. Chem. 291:5708-5720
Transforming growth factor (TGF) β1 acted through miR-130b to increase integrin α5 to promote migration of colorectal cancer cells.
Yi R., Li Y., Wang F., Gu J., Isaji T., Li J., Qi R., Zhu X. and Zhao Y.
Tumour Biol. 37, 10763-73, 2016
2015
Integrin α5 suppresses the phosphorylation of epidermal growth factor receptor and its cellular signaling of cell proliferation via N-glycosylation.
Hang, Q., Isaji, T., Hou, S., Im, S., Fukuda, T. and Gu, J
J. Biol. Chem.290:29345-29360
Significance of β-Galactoside α2,6 Sialyltranferase 1 in Cancers.
Lu J. and Gu J.
Molecules 20:7509-7527, 2015
Loss of α1,6-fucosyltransferase decreased hippocampal long-term potentiation: implications for core fucosylation in the regulation of AMPA receptor heteromerization and cellular signaling.
Gu, W., Fukuda, T., Isaji, T., Hang, Q., Lee, H., Sakai, S., Morise, J., Mitoma, J., Higashi, H., Taniguchi, N., Yawo, H., Oka, S. and Gu, J.
J. Biol. Chem.290:17566-17575
Loss of α1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating several cell signaling pathways.
Wang, Y., Fukuda, T., Isaji, T., Lu, J., Im, S., Hang, Q., Gu, W., Hou, S., Ohtsubo, K. and Gu, J.
FASEB J.8:3217-3227, 2015
Loss of α1,6-fucosyltransferase Suppressed Liver Regeneration: Implication of Core Fucose In The Regulation of Growth Factor Receptor-mediated Cellular Signaling.
Wang, Y., Fukuda, T., Isaji, T., Lu, J., Gu, W., Ohkubo, Y., Kamada, Y., Taniguchi, N., Miyoshi, E. and Gu, J.
Sci. Rep. 5, 8264; DOI:10.1038/srep08264, 2015
Core fucosylation of IgG-BCR is required for antigen recognition and antibody production.
Li, W., Ma, B.,(他8名)Fukuda, T., Gu, J., Zhang, J. and Taniguchi, N.
J. Immuno.194: 2596-2606, 2015
2014
β-Galactoside α2,6 Sialyltranferase 1 Promotes Transforming Growth Factor-β-Mediated Epithelial-Mesenchymal Transition.
Lu, J., Isaji, T., Im, S., Fukuda, T., Hashii, N., Takakura, D., Kawasaki, N. and Gu, J.
J Biol. Chem. 289: 34627-34641, 2014
MicroRNA 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin.
Zhao, Y., Miao, G., Li, Y., Isaji, T., Gu, J., Li, J., Qi, R.
PLoS One. 9(2):e87938, 2014
An Oncogenic Protein Golgi Phosphoprotein 3 Up-regulates Cell Migration via Sialylation.
Isaji, T., Im, S., Gu, W., Wang, Y., Hang, Q., Lu, J., Fukuda, T., Hashii, N., Takakura, D., Kawasaki, N., Miyoshi ,H., and Gu J.
J. Biol. Chem. 289: 20694-20705, 2014
Handbook of Glycosyltransferase and related genes (Fucosyltransferase 8 (α1,6-fucosyltransferase, FUT8))
Ihara, H., Tsukamoto, H., Gu, J., Miyoshi, E., Taniguchi, N. and Ikeda, Y.
Springer, 2014
Handbook of Glycosyltransferase and related genes (β1,4-N-Acetylglucosaminyltransferase III (GnT-III, GlcNAc-T III))
Ikeda, Y., Ihara, H., Tsukamoto, H., Gu, J. and Taniguchi, N.
Springer, 2014
Glycoscience: Biology and Medicine (Integrin α5β1 and its N-glycosylation.)
Jianguo Gu, Qinglei Hang, Tomohiko Fukuda, Tomoya Isaji.
Springer, 2014
Sugar Chains (α1,6-Fucosyltransferase knockout mice and Schizophrenia-like phenotype.)
Wei Gu, Tomohiko Fukuda, and Jianguo Gu.
Springer Japan, 2014
2013
E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V.
Pinho, SS., Figueiredo, J., Cabral, J., Carvalho, S., Dourado, J., Magalhães, A., Gärtner, F., Mendonça, AM., Isaji, T., Gu, J., Carneiro, F., Seruca, R., Taniguchi, N., Reis, CA.
Biochim. Biophys. Acta 1830: 2690-700, 2013
Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by N-glycosylation.
Kariya, Y., Kariya, Y and Gu, J.
Laminins: Structure, Biological Activity and Role in Disease, Nova Science Publishers Inc., NY Chapter 2, 1-23, 2013
Anti-tumor effects of exogenous ganglioside GM3 on bladder cancer in an orthotopic cancer model.
Wang, H., Isaji, T., Satoh, M., Li, D., Arai, Y. and Gu, J.
Urology 81, 210.e11-15, 2013
1,6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells: the implicated dual effects of Fut8 for TGF- /activin-mediated signaling.
Gu, W., Fukuda, T., Isaji, T., Hashimoto, H., Wang., Y and Gu, J.
FASEB J.27:3947-3958, 2013
2012
Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins. Kiyozumi, D., Takeichi, M., Nakano, I., Sato, Y., Fukuda, T. and Sekiguchi, K.
J. Cell Biol. 197: 677-89, 2012
Potential roles of N-glycosylation in cell adhesion. Gu, J., Isaji, T., Xu, Q., Kariya, Y., Gu, W., Fukuda, T. and Du, Y.
Glycoconj. J. 29: 599-607,2012
Chitosan oligosaccharides suppress production of nitric oxide in lipopolysaccharide- induced N9 murine microglial cells in vitro. Wei, P., Ma, P., Xu, Q., Bai, QH., Gu, J., Xi, H., Du, Y., Yu, C.
Glycoconj J. 29:285-95, 2012
Core fucosylation of mu heavy chains regulates the assembly of precursor B cell receptors and its intracellular signaling. Li, W., Liu, Q., Pang, Y., Jin, J., Wang, H., Cao, H., Li, Z., Wang, X., Ma, B., Chi, Y., Wang, R., Kondo, A., Gu, J. and Taniguchi, N.
J. Biol. Chem. 287:2500-2508, 2012
Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by TGF-β1 in epithelial cell lines. Xu, Q., Isaji, T., Lu, Y., Gu, W., Kondo, M., Fukuda, T., Du, Y. and Gu, J.
J. Biol. Chem. 287:16563-74, 2012
2011
Modulation of E-cadherin function and dysfunction by N-glycosylation. Pinho, SS., Seruca, R., Gärtner;, F., Yamaguchi, Y., Gu, J., Taniguchi, N. and Reis, CA.
Cell. Mol. Life Sci.68: 1011-1020, 2011
Wnt/β-catenin Signaling Down-regulates N-Acetylglucosaminyltransferase III Expression:The implication of two mutually exclusive pathways for regulation. Xu, Q., Akama, R., Isaji, T., Lu, Y., Hashimoto, H., Kariya, Y., Fukuda, T., Du Y., and Gu, J.
J. Biol. Chem.286: 4310-4318, 2011
α1,6-Fucosyltransferase-deficient mice exhibit multiple behavioral abnormalities associated with a schizophrenia-like phenotype: importance of the balance between the dopamine and serotonin systems. Fukuda, T., Hashimoto, H., Okayasu, N., Kameyama, A., Onogi, H., Nakagawasai, O, Nakazawa, T., Kurosawa, T., Hao, Y., Isaji, T., Tadano, T., Narimatsu, H., Taniguchi, N. and Gu, J.
J. Biol. Chem. 286: 18434-18443, 2011
N-glycosylation of β4 integrin controls the adhesion and motility of keratinocytes. Kariya, Y. and Gu, J.
PLoS One. 6:e27084. 2011
2010
Bisecting GlcNAc residues on laminin-332 downregulates galectin-3 dependent keratinocyte motility. Kariya, Y., Kawamura, C., Tabei, T. and Gu, J.
J. Biol. Chem.285:3330-3340, 2010
Functional roles of the bisecting GlcNAc in integrin-mediated cell adhesion. Isaji, T., Kariya, Y. Xu, Q., Fukuda, T., Taniguchi, N. and Gu, J.
Methods Enzymol. .480: 445-459, 2010
2009
Roles for laminin-332 and beta4 integrin in tumor progression. Kariya, Y., Kariya, Y. and Gu, J.
Mini-Rev Med Chem.9: 1284-91, 2009
Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells. Osumi, D., Takahashi, M., Miyoshi, E., Yokoe, S., Lee, SH., Noda, K., Nakamori, S., Gu, J., Ikeda, Y., Kuroki, Y., Sengoku, K., Ishikawa, M. and Taniguchi, N.
Cancer Sci.99:1304-1310, 2009
Requirement of Fut8 for the expression of vascular endothelial growth factor receptor-2: a new mechanism for the emphysema-like changes observed in Fut8-deficient mice. Wang, X., Fukuda, T., Li, W., Gao, C., Kondo, A., Matsumoto, A., Miyoshi, E., Taniguchi, N. and Gu, J.
J. Biochem.145:643-651, 2009
Importance of N-glycosylation on alpha5beta1 integrin for its biological functions. Gu, J., Isaji, T., Sato, Y., Kariya, Y. and Fukuda, T.
Biol. Pharm. Bull.32:780-785, 2009
N-glycosylation of the I-like domain of beta 1 integrin is essential for beta 1 integrin expression and biological function: Identification of the minimal N-glycosylation requirement for alpha 5beta 1. Isaji, T., Sato, Y., Fukuda, T. and Gu, J.
J. Biol. Chem.284:12207-12216, 2009
An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III. Sato, Y., Isaji, T., Tajiri, M., Yoshida-Yamamoto, S., Yoshinaka, T., Somehara, T., Fukuda, T., Wada, Y. and Gu, J.
J. Biol. Chem.284:11873-11881, 2009
A mutual regulation between cell-cell adhesion and N-glycosylation: implication of the bisecting GlcNAc for biological functions. Gu, J., Sato, Y., Kariya, Y., Isaji, T., Taniguchi, N. and Fukuda, T.
J. Proteome Res. 8:431-435, 2009
2008
Potential of N-glycan in cell adhesion and migration: As either a positive or negative regulator. Gu, J. and Taniguchi, N.
Cell Adhesion & Migration 2:4. 1-3, 2008
N-glycans Regulate Integrin alpha5beta1Functions. Gu, J., Sato, Y. and Isaji, T.
Experimental Glycoscience (Springer), 358-359, 2008
N-glycosylation of laminin-332 regulates its biological functions: A novel function of the bisecting GlcNAc. Kariya, Y., Kato, R., Itoh, S., Fukuda, T., Shibukawa, Y., Sanzen, N., Sekiguchi, K., Wada, Y., Kawasaki, N., Gu, J.
J. Biol. Chem. 283: 33036-33045, 2008
Human REM-8 is involved in membrane trafficking through early endosomes. Fujibayashi, A., Taguchi, T., Misaki, R., Ohtani, M., Dohmae, N., Takio, K., Yamada, M., Gu, J., Yamakami, M., Fukuda, M., Waguri, S., Uchiyama, Y., Yoshimori, T. and Sekiguchi, K.
Cell Structure Function. 33:35-50, 2008
Branched N-glycans regulate the biological functions of integrins and cadherins. Zhao, Y., Sato, Y., Isaji, T., Fukuda, T., Matsumoto, A., Miyoshi, E., Gu*, J., Taniguchi*, N. (* corresponding author)
FEBS J. 275: 1939-48, 2008
Functional roles of N-glycans in cell signaling and cell adhesion in cancer. Zhao, Y., Takahashi, M., Gu, J., Miyoshi, E., Matsumoto, A., Kitazume, S. and Taniguchi, N.
Cancer Sci. 99: 1304-10, 2008
Biochemical visualization of cell surface molecular clustering in living cells. Kotani, N., Gu, J., Isaji, T., Udaka, K., Taniguchi, N., and Honke, K.
Proc. Natl. Acad. Sci. 105: 7405-9, 2008
N-Acetylglucosaminyltransferase III Expression Is Regulated by Cell-Cell Adhesion via the E-cadherin-catenin-actin Complex. Akama, R., Sato, Y., Kariya, Y., Isaji, T., Fukuda, T., Lu, L., Taniguchi, N., Ozawa, M. and Gu, J.
PROTEOMICS.8: 3321-8, 2008
このページのトップへ
2007
N-glycans regulate integrin alpha5beta1 functions. Gu, J., Sato, Y. and Isaji, T.
Glycoscience Lab Manual, Elsevier Science Publishers, in press, 2007
Signaling and glycoproteins. Comprehesive. Zhao,Y., Gu, J. and Taniguchi, N.
glycoscience, Elsevier, Vol. 4, 249-266, 2007
Carbohydrate-binding specificity of a fucose-specific lectin from aspergillus oryzae: A novel probe for core fucose. Matsumura K, Higashida K, Ishida H, Hata Y, Yamamoto K, Shigeta M, Mizuno-Horikawa Y, Wang X, Miyoshi E, Gu J, Taniguchi N.
J. Biol .Chem. 282:15700-15708, 2007
Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity. Li W, Takahashi M, Shibukawa Y, Yokoe S, Gu J, Miyoshi E, Honke K, Ikeda Y, Taniguchi N.
Glycobiology 17:655-662, 2007
Crystal Structure of Mammalian alpha1,6-Fucosyltransferase, FUT8. Ihara H, Ikeda Y, Toma S, Wang X, Suzuki T, Gu J, Miyoshi E, Tsukihara T, Honke K, Matsumoto A, Nakagawa A, Taniguchi N.
Glycobiology 17:455-466, 2007
このページのトップへ
2006
From glycomics to functional glycomics of sugar chains: Identification of target proteins with functional changes using gene targeting mice and knock down cells of FUT8 as examples. Kondo A, Li W, Nakagawa T, Nakano M, Koyama N, Wang X, Gu J, Miyoshi E, Taniguchi N.
Biochim. Biophys. Acta 1764:1881-1889, 2006 (review).
A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase. Nakahara S, Saito T, Kondo N, Moriwaki K, Noda K, Ihara S, Takahashi M, Ide Y, Gu J, Inohara H, Katayama T, Tohyama M, Kubo T, Taniguchi N, Miyoshi E.
FASEB J. 20:2451-2459, 2006.
Phenotype changes of Fut8 knockout mouse: core fucosylation is crucial for the function of growth factor receptor(s).Wang X, Gu J, Miyoshi E, Honke K, Taniguchi N.
Methods Enzymol. 417:11-22, 2006.
Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions. Zhao Y, Itoh S, Wang X, Isaji T, Miyoshi E, Kariya Y, Miyazaki K, Kawasaki N, Taniguchi N, Gu J.
J. Biol. Chem. 281:38343-38350, 2006.
Decoding sugar functions by identifying target glycoproteins. Taniguchi N, Miyoshi E, Gu J, Honke K, Matsumoto A.
Curr. Opin. Struct. Biol.16:561-566, 2006 (review).
N-glycosylation of the beta-propeller domain of the integrin alpha5 subunit is essential for alpha5beta1 heterodimerization, expression on the cell surface, and its biological function. Isaji T, Sato Y, Zhao Y, Miyoshi E, Wada Y, Taniguchi N, Gu J.
J. Biol.Chem. 281:33258-33267, 2006.
N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration. Zhao Y, Nakagawa T, Itoh S, Inamori K, Isaji T, Kariya Y, Kondo A, Miyoshi E, Miyazaki K, Kawasaki N, Taniguchi N, Gu J.
J. Biol. Chem. 281:32122-32130, 2006.
Fucosylation of N-glycans regulates the secretion of hepatic glycoproteins into bile ducts. Nakagawa T, Uozumi N, Nakano M, Mizuno-Horikawa Y, Okuyama N, Taguchi T, Gu J, Kondo A, Taniguchi N, Miyoshi E.
J. Biol. Chem. 281: 29797-29806, 2006.
Down regulation of trypsinogen expression is associated with growth retardation in alpha1,6-fucosyltransferase-deficient mice: attenuation of proteinase-activated receptor 2 activity. Li W, Nakagawa T, Koyama N, Wang X, Jin J, Mizuno-Horikawa Y, Gu J, Miyoshi E, Kato I, Honke K, Taniguchi N and Kondo A.
Glycobiology 16:1007-19 2006.
Cell-cell interaction-dependent regulation of N-acetylglucosaminyltransferase III and the bisected N-glycans in GE11 epithelial cells: involvement of E-cadherin-mediated cell adhesion. Iijima, J., Zhao, Y., Isaji, T., Kameyama, A., Nakaya, S., Wang, X., Ihara, H., Cheng. X., Nakagawa, T., Miyoshi, E., Kondo, A., Narimatsu, H., Taniguchi, N., and Gu, J.
J. Biol. Chem. 281:13038-13046, 2006.
Core fucosylation regulates EGF receptor-mediated intracellular signaling. Wang, X., Gu, J*., Ihara, H., Miyoshi, E., Honke, K., Taniguchi, N. (*corresponding author)
J. Biol. Chem. 281:2572-2577, 2006.
beta-1,4-N-Acetylglucosaminyltransferase III potentiates beta1 integrin-mediated neuritogenesis induced by serum deprivation in Neuro2a cells. Shigeta, M., Shibukawa, Y., Ihara, H., Miyoshi, E., Taniguchi, N., Gu, J.
Glycobiology 16:564-571, 2006.
Fucosylated haptoglobin is a novel marker for pancreatic cancer: A detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation. Okuyama, N., Ide, Y., Nakano, M., Nakagawa, T., Yamanaka, K., Moriwaki, K., Murata, K., Ohigashi, H., Yokoyama, S., Eguchi, H., Ishikawa, O., Ito, T., Kato, M., Kasahara, A., Kawano, S., Gu, J., Taniguchi, N., and Miyoshi, E.
Int. J. Cancer 118:2803-2808, 2006.
Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain. Inamori, K., Mita, S., Gu, J*., Mizuno-Horikawa, Y., Miyoshi, E., Dennis, JW., and Taniguchi, N. (*corresponding author)
Biochim. Biophys. Acta 1760:678-84, 2006.
High expression of N-acetylglucosaminyltransferase V in favorable neuroblastomas: Involvement of its effect on apoptosis. Inamori, K., Gu, J*., Ohira, M., Kawasaki, A., Nakamura, Y., Nakagawa, T., Kondo, A., Miyoshi, E., Nakagawara, A., and Taniguchi, N. (*corresponding author)
FEBS Letters 580:627-632, 2006.
Aberrant expression of N-Acetylglucosaminyltransferase-IVa and IVb ( GnT-IVa and b ) in pancreatic cancer. Ide, Y., Miyoshi, E., Nakagawa, T., Gu, J., Tanemura, M., Nishida, T., Ito, T., Yamamoto, H., Kozutsumi, Y., and Taniguchi, N.
Biochem. Biophys. Res. Commun. 341:478-482, 2006.
Loss of core fucosylation of low-density lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum levels of insulin-like growth factor-binding protein 3 in fut8-/- mice. Lee,SH., Takahashi, M., Honke, K., Miyoshi, E., Osumi, D., Sakiyama, H., Ekuni, A., Wang, X., Inoue, S., Gu, J., Kadomatsu, K., Taniguchi, N.
J. Biochem.139:391-398, 2006.
このページのトップへ
2005
Overexpression of mutated Cu,Zn-SOD in neuroblastoma cells results in cytoskeletal change. Takamiya, R., Takahashi, M., Park, YS., Tawara, Y., Fujiwara, N., Miyamoto, Y., Gu, J., Suzuki, K., and Taniguchi, N.
Am. J. Physiol. Cell Physiol. 288, C253-259, 2005.
Bisecting GlcNAc Mediates the Binding of Annexin V to Hsp47. Gao, CX., Miyoshi, E., Uozumi, N., Takamiya, R., Wang, X., Noda, K., Gu, J., Honke, K., Wada, Y., and Taniguchi, N.
Glycobiology 15:1067-75, 2005.
Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M., Takahashi, M., Uozumi, N., Ihara, S., Lee, SH., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J., Suzuki, K., Kondo, A., Shapiro, SD., Lopez-Otin, C., Kuwaki, T., Okabe, M., Honke, K., and Taniguchi, N.
Proc. Natl. Acad. Sci. U S A. 102:15791-15796, 2005.
Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival. Xu, Z., Fukuda, T., Li, Y., Zha, X., Qin, J., and Wu, C.
J. Biol. Chem. 280:27631-27637, 2005.
Structure of an ultra weak protein-protein complex and its crucial role in regulation of cell morphology and motility. Vaynberg, J.*, Fukuda, T.*, Chen, K., Vinogradova, O., Velyvis, A., Tu, Y., Ng, L., Wu C., and Qin. J. (* equally contribute)
Mol. Cell. 17:513-523, 2005.
このページのトップへ
2004
Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. Isaji, T., Gu, J., Nishiuchi, R., Zhao, Y., Takahashi, M., Miyoshi, E., Honke, K., Sekiguchi, K., and Taniguchi, N.
J. Biol. Chem. 279:19747-19754, 2004.
beta1, 4-N-acetylglucosaminyltransferase III Down-regulates Neurite Outgrowth Induced by Co-stimulation of Epidermal Growth Factor and Integrins Through the Ras/ERK Signaling Pathway in PC12 cells. Gu, J., Zhao, Y., Isaji T., Shibukawa, Y., Ihara, H., Takahashi, M., Ikeda, Y., Miyoshi, E., Honke, K., and Taniguchi, N.
Glycobiology 14:177-186, 2004.
Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8. Fujiwara, H., Gu, J., and Sekiguchi, K.
Exp. Cell Res. 292:67-77, 2004.
N-acetylglucosaminyltransferase IX acts on the GlcNAcbeta 1,2-Manalpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Inamori, KI., Endo, T., Gu, J., Matsuo, I., Ito, Y., Fujii, S., Iwasaki, H., Narimatsu, H., Miyoshi, E., Honke, K., and Taniguchi, N.
J. Biol. Chem. 279:2337-2340, 2004.
Differential Regulation of Focal Adhesion Kinase and Paxillin Phosphorylation by the Small GTP-binding Protein Rho in Human Corneal Epithelial Cells. Saito, J., Morishige, N., Chikama, T., Gu, J., Sekiguchi, K., and Nishida, T.
Jpn. J. Ophthalmol. 48:199-207, 2004.
Functional glycomics and evidence for gain- and loss-of-functions of target proteins for glycosyltransferases involved in N-glycan biosynthesis: their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer. Taniguchi, N., Gu, J. Takahashi, M., and Miyoshi, E.
Proc. Japan Acad., Ser. B, 80, 82-91, 2004 (review).
Regulation of integrin functions by N-glycans. Gu, J., and Taniguchi, N.
Glycoconj. J., 21:9-15, 2004 (review).
Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Astrof, S., Crowley, D., George, EL., Fukuda, T., Sekiguchi, K., Hanahan, D., and Hynes RO.
Mol. Cell Biol. 24:8662-8670, 2004.
このページのトップへ
2003
Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. Noda, K., Miyoshi, E., Gu, J., Gao, C-X., Nakahara, S., Kitada, T., Honke, K., Suzuki, K., Yoshihara, H., Yoshikawa, K., Kawano, K., Tonetti, M., Kasahara, A., Hori M, Hayashi, N., and Taniguchi, N.
Cancer Res. 63:6282-6289, 2003.
CD151 regulates epithelial cell-cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization. Shigeta, M., Sanzen, N., Ozawa, M., Gu, J., Hasegawa, H., and Sekiguchi, K.
J. Cell Biol. 163:165-176, 2003.
Molecular Cloning and Characterization of Human GnT-IX, A Novel b1,6-N-Acetylglucosaminyltransferase That Is Specifically Expressed in The Brain. Inamori, K., Endo, T., Ide, Y., Fujii, S., Gu, J., Honke, K., and Taniguchi, N.
J. Biol. Chem. 278:43102-43109, 2003.
Recombinant Expression and Characterization of a Novel Fibronectin Isoform Expressed in Cartilaginous Tissues. Kozaki, T., Matsui, Y., Gu, J., Nishiuchi, R., Sugiura, N., Kimata, K., Ozono, K., Yoshikawa, H., and Sekiguchi, K.
J. Biol. Chem. 278:50546-50553, 2003.
Csk regulates integrin-mediated signals: involvement of differential activation of ERK and Akt. Gu, J., Nada, S., Okada, M., and Sekiguchi, K.
Biochem. Biophys. Res. Commun. 303:937-977, 2003.
Characterization of the ligand binding specificities of integrin a3b1 and a6b1 using a panel of purified laminin isoforms containing distinct a chains. Nishiuchi, R., Murayama, O., Fujiwara, H., Gu, J., Kawakami, T., Aimoto, S., Wada, Y., and Sekiguchi, K.
J. Biochem. 134:497-504, 2003.
Involvement of Oligosaccharide Change in a5b1 Integrin in a Cisplatin-Resistant Human Squamous Cell Carcinoma Cell Line. Nakahara, S., Miyoshi, E., Noda, K., Ihara, S., Gu, J., Honke, K., Inohara, H., Kubo, T., and Taniguchi, N.
Mol. Cancer Therap. 2:1207-1214, 2003.
CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt. Fukuda, T., Guo, L., Shi, X., Wu, C.
J. Cell. Biol. 160:1001-1008, 2003.
PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. Fukuda, T., Chen, K., Shi, X., Wu, C.
J. Biol. Chem. 278:51324-51333, 2003.
このページのトップへ
2002
Laminin-10/11 and Fibronectin Differentially Prevent Apoptosis Induced by Serum Removal via PI 3-kinase/Akt- and MEK1/ERK-dependent Pathways. Gu, J., Fujibayashi, A., Yamada, KM., and Sekiguchi, K.
J. Biol. Chem. 277:19922-19928, 2002.
Matrix metalloproteinase-2 is involved in A549 cell migration on laminin-10/11. Gu, J., Nishiuchi, R., and Sekiguchi, K.
Biochem. Biophys. Res. Commun. 296:69-73, 2002.
Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. Fukuda, T., Yoshida, N., Kataoka, Y., Manabe, R., Mizuno-Horikawa, Y., Sato, M., Kuriyama, K., Yasui, N., Sekiguchi, K.
Cancer Res. 62:5603-5610, 2002.
2001
Laminin-10/11 and Fibronectin Differentially Regulate Integrin-dependent Rho and Rac Activition via p130Cas/CrkII/DOCK180 Pathway. Gu, J., Sumida, Y., Sanzen, N., and Sekiguchi, K.
J. Biol. Chem. 276:27090-27097, 2001.
2000
Integrin a1b1-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation. Li, BS., Zhang, l., Gu, J., Amin, ND., and Pant, HC.
J. Neurosci. 20:6055-6062, 2000.
The domains of human fibronectin mediating the binding of alpha antigen, the most immunopotent antigen of mycobacteria that induces protective immunity against mycobacterial infection. Naito, M., Fukuda, T., Sekiguchi, K., and Yamada, T.
Biochem. J.. 347:725-731, 2000.
このページのトップへ
1999
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. Gu, J., Tamura, M., Pankov, R., Danen, E.H.J., Takino, T., Matsumoto, K., and Yamada, KM.
J. Cell Biol. 146:389-403, 1999.
Tumor suppressor PTEN inhibition of cell invasion, migration, and growht: differential involvement of focal adhesion kinase and p130cas. Tamura, M., Gu, J., Takino, T., and Yamada, KM.
Cancer Res. 59:442-449, 1999.
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Podsypanina, K., Ellenson, LH., Nemes A., Gu, J., Tamura, M., Yamada, KM, Cordon-Cardo, C., Catoretti, G., Fisher, P., and Parsons, R.
Proc. Natl. Acad. Sci. 98:1563-1568, 1999.
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. Tamura, M., Gu, J., Danen, E.H.J., Takino, T., and Yamada KM.
J. Biol. Chem. 274:20693-20703, 1999.
Activation of mitogen-activated protein kinases cascade results in phosphorylation of NF-M tail domains in transfected NIH 3T3 cells. Li, BS., Veeranna, I., Gu, J., Grant P., and Pant, HC.
Eur. J. Biochem. 262:1-8, 1999.
The PTEN gene and integrin signaling in cancer. Tamura, M., Gu, J., Tran, H., and Yamada, KM.
J. Natl. Cancer Inst. 91:1820-1828, 1999 (review).
1998
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R., and Yamada, KM.
Science. 280:1614-1617, 1998.
Tumor suppressor PTEN inhibits Integrin- and growth factor-mediated MAP kinase signaling pathways. Gu, J., Tamura, M., and Yamada, KM.
J. Cell Biol. 143:1375-1383, 1998.
このページのトップへ