「－腫瘍指向性ポリマーナノ粒子ラクトソーム－ 核医学分子イメージングプローブとしての開発と展望」
山本文彦
東北医科薬科大学研究誌
第63号 p. 21-43
「放射線で誘発される細胞死:アポトーシス、オートファジー、ネクロプトーシス」
桑原義和、鈴木正敏、漆原佑介、齋藤陽平、山本由美、富田和男、佐藤友昭、山本文彦、栗政明弘、福本 学
東北医科薬科大学研究誌
第63号 p. 63-81
The involvement of mitochondrial membrane potential in cross-resistance between radiation and docetaxel
Kuwahara Y., Roudkenar M.H., Suzuki M., Urushihara Y., Fukumoto M., Saito Y., Fukumoto M.
Int. J. Radiat. Oncol. Biol. Phys.
96, 556-565
Isomeric iodinated analogs of nimesulide: synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells
Yamamoto Y., Arai J., Hisa T., Saito Y., Mukai T., Ohshima T., Maeda M., and Yamamoto F.
Bioorg. Med. Chem.
24, 3727-33
Inflammation-Induced Synergetic Enhancement of Nanoparticle Treatments with DOXIL® and 90
Y-Lactosome for Orthotopic Mammary Tumor
Kurihara K., Ueda M., Hara I., Hara E., Sano .K, Makino A., Ozeki E., Yamamoto F., Saji H., Togashi K., Kimura S.
J. Nanopart. Res.
18, 137
山本文彦，タリウムの光と影，サイエンスアイ新書シリーズ 知っておきたい化学物質の常識８４ 左巻健男・一色健司編著 SBクリエイティブ, 16-17 ISBN978-4-7973-5689-2
山本文彦，ヒ素は愚者の毒物、未来を担う存在，サイエンスアイ新書シリーズ 知っておきたい化学物質の常識８４ 左巻健男・一色健司編著 SBクリエイティブ, 18-19 ISBN978-4-7973-5689-2
山本文彦，自然にもある放射能と放射線，サイエンスアイ新書シリーズ 知っておきたい化学物質の常識８４ 左巻健男・一色健司編著 SBクリエイティブ,80-81 ISBN978-4-7973-5689-2
山本文彦，食品への放射線照射、その安全性，サイエンスアイ新書シリーズ 知っておきたい化学物質の常識８４ 左巻健男・一色健司編著 SBクリエイティブ,112-113 ISBN978-4-7973-5689-2
山本文彦，ラジウム温泉の放射能は体にいいの？，サイエンスアイ新書シリーズ 知っておきたい化学物質の常識８４ 左巻健男・一色健司編著 SBクリエイティブ, 170-171 ISBN978-4-7973-5689-2
山本文彦，ハムやソーセージに使われている保存剤エリソルビン酸って？，
サイエンスアイ新書シリーズ 知っていると安心できる成分表示の知識(左巻健男・池田恵一編著) SBクリエイティブ、，78-79
山本文彦，サラダ油に入っているビタミンＥの効果は？，
サイエンスアイ新書シリーズ 知っていると安心できる成分表示の知識(左巻健男・池田恵一編著) SBクリエイティブ、，84-85
山本文彦，歯磨き剤のフッ化物って恐いもの？，
サイエンスアイ新書シリーズ 知っていると安心できる成分表示の知識(左巻健男・池田恵一編著) SBクリエイティブ、，152-153
(2015)
Isomeric Methoxy Analogs of Nimesulide for Development of Brain Cyclooxygense-2
(COX-2) -targeted Imaging Agents: Synthesis, in Vitro COX-2-Inhibitory Potency, and Cellular Transport Properties
Yamamoto Y., Hisa T., Arai J., Saito Y., Yamamoto F., Mukai T., Ohshima T., Maeda M. and Ohkubo Y.
Bioorg. Med. Chem.
23, 6807-6814.
Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development.
Sugimoto C., Hasegawa A., Saito Y., Fukuyo Y., Chiu KB., Cai Y., Breed MW., Mori K., Roy CJ., Lackner AA., Kim WK., Didier ES. and Kuroda MJ.
J. Immunol.
195(4), 1774-81.
Loss of EGF-dependent cell proliferation ability on radioresistant cell HepG2-8960-R
Saito Y., Abiko R., Kishida A., Kuwahara Y., Yamamoto Y., Yamamoto F., Fukumoto M., and Ohkubo Y.
Cell Biochem. Funct.,
33, 73-9.
Loss of α1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling
Yuqin Wang, Tomohiko Fukuda, Tomoya Isaji, Jishun Lu, Wei Gu, Ho-hsun Lee, Yasuhito Ohkubo, Yoshihiro Kamada, Naoyuki Taniguchi, Eiji Miyoshi Jianguo Gu
Sci. Rep.,
5, 8264; DOI:10.1038/srep08264u
(2014)
Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance
Fukumoto M., Tatsuya Amanuma T., Yoshikazu Kuwahara Y., Shimura T., Suzuki M., Mori S.,Kumamoto H., Saito Y., Ohkubo Y., Duan Z., Sano K., Oguchi T., Kainuma K., Usami S., Kinoshita K., Lee I. and Fukumoto M
Cancer Science,
105, 1351-1359
Anomalous change of atmospheric radon concentration before the 2011 Tohoku-Oki Earthquake in Japan
Hayashi K., Yasuoka Y., Nagahama H., Muto J., Suzuki T., Homma Y., Yamamoto F., Takahashi K., Mukai T.
高エネルギー加速器研究機構(KEK) 2014, Proceedings of the 15th Workshop on Environmental Radioactivity.,
23-28
Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin α5β1
Tanaka R., Seki Y., Saito Y., Kamiya M., Fujita M., Okutsu H., Iyoda T., Takai T., Owaki T., Yajima H., Taira J., Hayashi R., Kodama H., Matsunaga T., and Fukai F.
J. Biol. Chem.,
289, 17699-17708
Synthesis and initial evaluation of radioiodine labeled A3B-type Lactosome as an imaging probe of tumor and/or inflammation
Yamamoto F., Kimura M., Makino A., Yamamoto Y., Saito Y., Ozeki E., Kimura S., Ohkubo Y.
J. Nucl. Med.,
55, (Suppl 1), 203P-204P
Targeting of tumor endothelial cells combining 2 Gy/day of X-ray with Everolimus is the effective modality for overcoming clinically relevant radioresistant tumors
Kuwahara Y, Mori M, Kitahara S, Fukumoto M, Ezaki T, Mori S, Echigo S, Ohkubo Y, Fukumoto M
Cancer Med.,
3, 310-21
(2013)
Radionuclide Therapy Using Nanoparticle of 131I-Lactosome in Combination with Percutaneous Ethanol Injection Therapy
Hara E., Makino A., Kurihara K., Ueda M., Hara I., Kawabe T., Yamamoto F., Ozeki E., Togashi K., Kimura S
J. Nanopart. Res.,
15(12), article:2131
Radiosynthesis and initial evaluation of 18F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide.
Yamamoto F., Yamahara R., Makino A., Kurihara K., Tsukada H., Hara E., Hara I., Kizaka-Kondoh S., Ohkubo Y., Ozeki E., Kimura S.
Nucl. Med. Biol.,
40(3), 387-394
実験室の基盤設備、薬学生のための実習実験安全ガイド（久保陽徳、小島周二、増野匡彦監修）
大久保恭仁
東京化学同人
104-121
学生・研究者の実験・研究マナー、薬学生のための実習実験安全ガイド（久保陽徳、小島周二、増野匡彦監修）
大久保恭仁
東京化学同人
134-142
(2012)
Critical role of farnesoid X receptor (FXR) for hepatocellular carcinoma cell proliferation.
Fujino T., Takeuchi A., Maruko-Ohtake A., Ohtake Y., Satoh J., Kobayashi T., Tanaka T., Ito H., Sakamaki R., Kashimura R., Ando K., Nishimaki-Mogami T., Ohkubo Y., Kitamura N., Sato R., Kikugawa K., Hayakawa M.
J. Biochem.,
152(6), 577-86
Effect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes.
Kobayashi T., Saito Y., Ohtake Y., Maruko A., Yamamoto Y., Yamamoto F., Kuwahara Y., Fukumoto M.,Fukumoto M., Ohkubo Y.
Am. J. Physiol.,
303(7), G861-9
Pharmacokinetic Change of Nanoparticulate Formulation “Lactosome” on Multiple Administrations.
Hara E., Makino A., Kurihara K., Yamamoto F., Ozeki E., Kimura S.
Int. Immunopharmacol.,
14(3), 261-266
Control of in vivo blood clearance time of polymeric micelle by stereochemistry of amphiphilic polydepsipeptides
Makino A., Hara E., Hara I., Yamahara R., Kurihara K., Ozeki E., Yamamoto F., Kimura S.
J. Control. Release,
161(3), 821-825
Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment
Itagaki K., Naito T., Iwakiri R., Haga M., Miura S., Saito Y., Owaki T., Kamiya S., Iyoda T., Yajima H., Iwashita S., Ejiri SI., Fukai F.
J. Biol. Chem.,
287(19), 16037-46
5-O-(4-[125I]Iodobenzyl)-L-ascorbic acid: Electrophilic Radioiodination and Biodistribution in Mice.
Kim J., Kino T., Kato H., Yamamoto F., Sano K., Mukai T., Maeda M.
Chem. Pharm. Bull.,
60(2), 235-40
Evasion from the accelerated blood clearance (ABC) phenomenon of "Lactosome" by micelle size control.
Makino A., Takeuchi E., Hara I., Yamahara R., Ozeki E., Kurihara K., Yamamoto F., Kimura S.
Mol. Imaging Biol.,
14 (Suppl.1), S67
(2011)
薬学テキストシリーズ 放射化学・放射性医薬品学
大久保恭仁, 小島周二 編著, 加藤真介, 工藤なをみ, 坂本光, 佐々木徹, 月本光俊, 山本文彦 著
朝倉書店
Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy
Kuwahara Y., Oikawa T., Ochiai Y., Rouhkenar MH., Fukumoto M., Shimura T., Ohtake Y., Ohkubo Y., Mori S., Uchiyama Y., Fukumoto M.
Cell Death and Disease
2,e177
11C-Labeled Analogs of Indomethacin Esters and Amides for Brain Cyclooxygenase-2 Imaging: Radiosynthesis, In Vitro Evaluation and In Vivo Characteristics in Mice
Yamamoto Y., Toyohara J., Ishiwata K., Sano K., Yamamoto F., Mukai T., Maeda M.
Chem. Pharm. Bull.
59(8), 938-946
(2010)
"Lactosome" a potential nano-ordered carrier for molecular imaging composed of a poly(L-lactic acid) - block -poly(sarcosine) amphiphilic polydepsipeptide and poly(lactic acid) derivatives.
Makino A., Yamahara R., Hara I., Takeuchi E., Ozeki E., Kurihara K., Kizaka-Kondoh S., Yamamoto F., Shimizu A., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S812
ABC phenomenon with lactosome studied by in vivo NIRF imaging
Takeuchi E., Hara I., Yamahara R., Makino A., Kurihara K., Yamamoto F., Kizaka-Kondoh S., Shimizu A., Ozeki E., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S835
Development of Near-Infrared Fluorescence Probes for In Vivo Tumor Imaging with Using an Amphiphilic Polydepsipeptide Micelle "Lactosome"
Hara I., Yamahara R., Takeuchi E., Makino A., Kurihara K., Yamamoto F., Kizaka-Kondoh S., Shimizu A., Ozeki E., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S873
A fluorescent imaging of the murine orthotopic brain tumor, using new nanocarrier "Lactosome"
Kurihara K., Yamamoto F., Yamaguchi M., Arakawa Y., Hara I., Ozeki E., Makino A., Togashi K., Shimizu A., Kimura S
Mol. Imaging Biol.
12 (Suppl.2), S876
Development of novel radioiodine labeled nanocarrier "Lactosome" and initial evaluation as a tumor imaging probe
Yamamoto F., Yamahara R., Kurihara K., Takeuchi E., Hara I., Makino A., Kizaka-Kondoh S., Shimizu A., Ozeki E., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S948
Development of a novel radioisotope labeled tumor imaging probe for PET "18F-Lactosome"
Yamahara R., Yamamoto F., Kurihara K., Tsukada H., Takeuchi E., Hara I., Makino A., Shimizu A.. Kizaka-Kondoh S., Ozeki E., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S995
1-(3’-[125I]Iodophenyl)-3-methy-2-pyrazolin-5-one: Preparation, Solution Stability, and Biodistribution in Normal Mice
Sano Y., Motomura T., Yamamoto F., Fukuda M., Mukai T., Maeda M.
Chem. Pharm. Bull.
58(8), 1020-1025
Development and initial evaluation of novel fluorine-18 labeled nanocarrier "Lactosome" as a tumor imaging probe for PET
Yamamoto F., Yamahara R., Kurihara K., Tsukada H., Takeuchi E., Hara I., Makino A., Kizaka-Kondoh S., Ozeki E., Kimura S.
J. Nucl. Med.,
51(5), (Suppl 2), 304P
Norepinephrine modulates the zonally different hepatocyte proliferation through the regulation of transglutaminase activity
Ohtake Y., Kobayashi T., Maruko A., Ohishi N., Yamamoto F., Katoh S., Ohkubo Y.
Am. J. Physiol.
299(1), G106-114
The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure
Kuwahara Y., Mori M., Oikawa T., Shimura T., Ohtake Y., Mori S., Ohkubo Y., Fukumoto M.
J. Radiat. Res.
51, 297-302
X-irradiation－induced down-regulation of the EGF receptor in primary cultured rat hepatocytes
Maruko A., Ohtake Y., Kawaguchi M., Kobayashi T., Baba T., Kuwahara Y., Nakagawa H., Shimura T., Fukumoto M., Ohkubo Y.
Radiat. Res.
173, 620-628
低線量の放射線・放射能は害なのか益なのか？，RikaTan 12月号（第4巻12号 通巻672号）
山本文彦
文一総合出版，
p16-19
放射線の医学への利用，RikaTan 12月号（第4巻12号 通巻672号），
山本文彦
文一総合出版，
p20-23