Isomeric Methoxy Analogs of Nimesulide for Development of Brain Cyclooxygense-2 (COX-2) -targeted Imaging Agents: Synthesis, in Vitro COX-2-Inhibitory Potency, and Cellular Transport Properties
Yamamoto Y., Hisa T., Arai J., Saito Y., Yamamoto F., Mukai T., Ohshima T., Maeda M. and Ohkubo Y.
Bioorg. Med. Chem.
23, 6807-6814.
Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development.
Sugimoto C., Hasegawa A., Saito Y., Fukuyo Y., Chiu KB., Cai Y., Breed MW., Mori K., Roy CJ., Lackner AA., Kim WK., Didier ES. and Kuroda MJ.
J. Immunol.
195(4), 1774-81.
Loss of EGF-dependent cell proliferation ability on radioresistant cell HepG2-8960-R
Saito Y., Abiko R., Kishida A., Kuwahara Y., Yamamoto Y., Yamamoto F., Fukumoto M., and Ohkubo Y.
Cell Biochem. Funct.,
33, 73-9.
Loss of α1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling
Yuqin Wang, Tomohiko Fukuda, Tomoya Isaji, Jishun Lu, Wei Gu, Ho-hsun Lee, Yasuhito Ohkubo, Yoshihiro Kamada, Naoyuki Taniguchi, Eiji Miyoshi Jianguo Gu
Sci. Rep.,
5, 8264; DOI:10.1038/srep08264u
Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance
Fukumoto M., Tatsuya Amanuma T., Yoshikazu Kuwahara Y., Shimura T., Suzuki M., Mori S.,Kumamoto H., Saito Y., Ohkubo Y., Duan Z., Sano K., Oguchi T., Kainuma K., Usami S., Kinoshita K., Lee I. and Fukumoto M
Cancer Science,
105, 1351-1359
Anomalous change of atmospheric radon concentration before the 2011 Tohoku-Oki Earthquake in Japan
Hayashi K., Yasuoka Y., Nagahama H., Muto J., Suzuki T., Homma Y., Yamamoto F., Takahashi K., Mukai T.
高エネルギー加速器研究機構(KEK) 2014, Proceedings of the 15th Workshop on Environmental Radioactivity.,
Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin α5β1
Tanaka R., Seki Y., Saito Y., Kamiya M., Fujita M., Okutsu H., Iyoda T., Takai T., Owaki T., Yajima H., Taira J., Hayashi R., Kodama H., Matsunaga T., and Fukai F.
J. Biol. Chem.,
289, 17699-17708
Synthesis and initial evaluation of radioiodine labeled A3B-type Lactosome as an imaging probe of tumor and/or inflammation
Yamamoto F., Kimura M., Makino A., Yamamoto Y., Saito Y., Ozeki E., Kimura S., Ohkubo Y.
J. Nucl. Med.,
55, (Suppl 1), 203P-204P
Targeting of tumor endothelial cells combining 2 Gy/day of X-ray with Everolimus is the effective modality for overcoming clinically relevant radioresistant tumors
Kuwahara Y, Mori M, Kitahara S, Fukumoto M, Ezaki T, Mori S, Echigo S, Ohkubo Y, Fukumoto M
Cancer Med.,
3, 310-21
Radionuclide Therapy Using Nanoparticle of 131I-Lactosome in Combination with Percutaneous Ethanol Injection Therapy
Hara E., Makino A., Kurihara K., Ueda M., Hara I., Kawabe T., Yamamoto F., Ozeki E., Togashi K., Kimura S
J. Nanopart. Res.,
15(12), article:2131
Radiosynthesis and initial evaluation of 18F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide.
Yamamoto F., Yamahara R., Makino A., Kurihara K., Tsukada H., Hara E., Hara I., Kizaka-Kondoh S., Ohkubo Y., Ozeki E., Kimura S.
Nucl. Med. Biol.,
40(3), 387-394
Critical role of farnesoid X receptor (FXR) for hepatocellular carcinoma cell proliferation.
Fujino T., Takeuchi A., Maruko-Ohtake A., Ohtake Y., Satoh J., Kobayashi T., Tanaka T., Ito H., Sakamaki R., Kashimura R., Ando K., Nishimaki-Mogami T., Ohkubo Y., Kitamura N., Sato R., Kikugawa K., Hayakawa M.
J. Biochem.,
152(6), 577-86
Effect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes.
Kobayashi T., Saito Y., Ohtake Y., Maruko A., Yamamoto Y., Yamamoto F., Kuwahara Y., Fukumoto M.,Fukumoto M., Ohkubo Y.
Am. J. Physiol.,
303(7), G861-9
Pharmacokinetic Change of Nanoparticulate Formulation “Lactosome” on Multiple Administrations.
Hara E., Makino A., Kurihara K., Yamamoto F., Ozeki E., Kimura S.
Int. Immunopharmacol.,
14(3), 261-266
Control of in vivo blood clearance time of polymeric micelle by stereochemistry of amphiphilic polydepsipeptides
Makino A., Hara E., Hara I., Yamahara R., Kurihara K., Ozeki E., Yamamoto F., Kimura S.
J. Control. Release,
161(3), 821-825
Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment
Itagaki K., Naito T., Iwakiri R., Haga M., Miura S., Saito Y., Owaki T., Kamiya S., Iyoda T., Yajima H., Iwashita S., Ejiri SI., Fukai F.
J. Biol. Chem.,
287(19), 16037-46
5-O-(4-[125I]Iodobenzyl)-L-ascorbic acid: Electrophilic Radioiodination and Biodistribution in Mice.
Kim J., Kino T., Kato H., Yamamoto F., Sano K., Mukai T., Maeda M.
Chem. Pharm. Bull.,
60(2), 235-40
Evasion from the accelerated blood clearance (ABC) phenomenon of "Lactosome" by micelle size control.
Makino A., Takeuchi E., Hara I., Yamahara R., Ozeki E., Kurihara K., Yamamoto F., Kimura S.
Mol. Imaging Biol.,
14 (Suppl.1), S67
薬学テキストシリーズ 放射化学・放射性医薬品学
大久保恭仁, 小島周二 編著, 加藤真介, 工藤なをみ, 坂本光, 佐々木徹, 月本光俊, 山本文彦 著
Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy
Kuwahara Y., Oikawa T., Ochiai Y., Rouhkenar MH., Fukumoto M., Shimura T., Ohtake Y., Ohkubo Y., Mori S., Uchiyama Y., Fukumoto M.
Cell Death and Disease
11C-Labeled Analogs of Indomethacin Esters and Amides for Brain Cyclooxygenase-2 Imaging: Radiosynthesis, In Vitro Evaluation and In Vivo Characteristics in Mice
Yamamoto Y., Toyohara J., Ishiwata K., Sano K., Yamamoto F., Mukai T., Maeda M.
Chem. Pharm. Bull.
59(8), 938-946
"Lactosome" a potential nano-ordered carrier for molecular imaging composed of a poly(L-lactic acid) - block -poly(sarcosine) amphiphilic polydepsipeptide and poly(lactic acid) derivatives.
Makino A., Yamahara R., Hara I., Takeuchi E., Ozeki E., Kurihara K., Kizaka-Kondoh S., Yamamoto F., Shimizu A., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S812
ABC phenomenon with lactosome studied by in vivo NIRF imaging
Takeuchi E., Hara I., Yamahara R., Makino A., Kurihara K., Yamamoto F., Kizaka-Kondoh S., Shimizu A., Ozeki E., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S835
Development of Near-Infrared Fluorescence Probes for In Vivo Tumor Imaging with Using an Amphiphilic Polydepsipeptide Micelle "Lactosome"
Hara I., Yamahara R., Takeuchi E., Makino A., Kurihara K., Yamamoto F., Kizaka-Kondoh S., Shimizu A., Ozeki E., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S873
A fluorescent imaging of the murine orthotopic brain tumor, using new nanocarrier "Lactosome"
Kurihara K., Yamamoto F., Yamaguchi M., Arakawa Y., Hara I., Ozeki E., Makino A., Togashi K., Shimizu A., Kimura S
Mol. Imaging Biol.
12 (Suppl.2), S876
Development of novel radioiodine labeled nanocarrier "Lactosome" and initial evaluation as a tumor imaging probe
Yamamoto F., Yamahara R., Kurihara K., Takeuchi E., Hara I., Makino A., Kizaka-Kondoh S., Shimizu A., Ozeki E., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S948
Development of a novel radioisotope labeled tumor imaging probe for PET "18F-Lactosome"
Yamahara R., Yamamoto F., Kurihara K., Tsukada H., Takeuchi E., Hara I., Makino A., Shimizu A.. Kizaka-Kondoh S., Ozeki E., Kimura S.
Mol. Imaging Biol.
12 (Suppl.2), S995
1-(3’-[125I]Iodophenyl)-3-methy-2-pyrazolin-5-one: Preparation, Solution Stability, and Biodistribution in Normal Mice
Sano Y., Motomura T., Yamamoto F., Fukuda M., Mukai T., Maeda M.
Chem. Pharm. Bull.
58(8), 1020-1025
Development and initial evaluation of novel fluorine-18 labeled nanocarrier "Lactosome" as a tumor imaging probe for PET
Yamamoto F., Yamahara R., Kurihara K., Tsukada H., Takeuchi E., Hara I., Makino A., Kizaka-Kondoh S., Ozeki E., Kimura S.
J. Nucl. Med.,
51(5), (Suppl 2), 304P
Norepinephrine modulates the zonally different hepatocyte proliferation through the regulation of transglutaminase activity
Ohtake Y., Kobayashi T., Maruko A., Ohishi N., Yamamoto F., Katoh S., Ohkubo Y.
Am. J. Physiol.
299(1), G106-114
The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure
Kuwahara Y., Mori M., Oikawa T., Shimura T., Ohtake Y., Mori S., Ohkubo Y., Fukumoto M.
J. Radiat. Res.
51, 297-302
X-irradiation-induced down-regulation of the EGF receptor in primary cultured rat hepatocytes
Maruko A., Ohtake Y., Kawaguchi M., Kobayashi T., Baba T., Kuwahara Y., Nakagawa H., Shimura T., Fukumoto M., Ohkubo Y.
Radiat. Res.
173, 620-628
低線量の放射線・放射能は害なのか益なのか?,RikaTan 12月号(第4巻12号 通巻672号)
放射線の医学への利用,RikaTan 12月号(第4巻12号 通巻672号),