ŠÂ‹«‰q¶Šw‹³Žº
Department of Environmental Health
ƒCƒ[ƒW

§981-8558
‹{éŒ§å‘äŽsÂ—t‹æ¬¼“‡4’š–Ú4-1
“Œ–k–ò‰È‘åŠw@ŠÂ‹«‰q¶Šw‹³Žº
TEL 022-234-4183
i“àü 3811, 3812, 3813, 3814j
FAX 022-275-2013
ƒƒ“ƒo[
@
‹³@Žö
‰i“c@´@
u@Žt
âŒûC•½@ŒF’J@Œ’@
•@‹³
²X–ؐ’Œõ@
D@3
ûü‹´¹Œå@@
D@1
ˆîŒ©Œh‘¾@²“¡@—T@@
M@2
À“cŠìO@
M@1
´¼Fs@²X–Ø“µ@’†àV—mˆê@–ìè’q‹I@
–òŠw6”N
¬¼–ƒ”üŽq@å@‘”ü@ŠpŠÔŒ³”ü@âV“¡Ž“ÞŽq@ç—t•¶”Ž@Š}Œ´ @Ê@•šŒ©@Ê@ˆ¢•”‘å‹I@›–썂O@âV“¡—Y‘å
–òŠw5”N
âV“¡—R‹M@–Ø‘ºŒOŽq@H“¡—T‘¾@Î‹´K“ށ@’|‰®—¢Œb@‹ß]’m¢@ª–{‚ ‚ä‚݁@‘D‰zL‘å@ŽR“àØ–í@“n•Ó”ü’qŽq@‘Š T‘¾˜Y@¬—щpŽk@‰¡ì—D—¢
¶–½4”N
ûü‹´—¢Ø@‹g“c”ü“s—¢


Œ¤‹†“à—e
“–‹³Žº‚Å‚Í–òŠw—̈æ‚É‚¨‚¯‚éˆã–ò•iˆÀ‘S«Šw‚¨‚æ‚ъ‹«‰q¶Šw‚ÌŠÏ“_‚©‚çA–ò•¨‘ãŽÓ‚𒆐S‚Æ‚µ‚½ˆÈ‰º‚̃e[ƒ}‚ɂ‚¢‚ÄŒ¤‹†‚ði‚ß‚Ä‚¢‚éB
1D–ò•¨‚âŠÂ‹«‰˜õ•¨Ž¿‚Ȃǂ̓Ő«”­Œ»‚É‚¨‚¯‚éŒÂl·‚Ì•ªŽqƒƒJƒjƒYƒ€‰ð–¾‚ÉŠÖ‚·‚錤‹†
@–ò•¨‚âŠÂ‹«‰˜õ•¨Ž¿‚È‚Ç‚ðÛŽæ‚·‚邱‚Æ‚É‚æ‚Á‚Ĉø‚«‹N‚±‚³‚ê‚é“Ő«”­Œ»‚Ì’ö“x‚́AŒÂlŠÔ‚Å‘å‚«‚­ˆÙ‚È‚Á‚Ä‚¢‚éB‚»‚ÌŒ´ˆö‚Æ‚µ‚āAˆâ“`“I‚È—vˆö‚Ɗ‹«“I‚È—vˆö‚ªŽå‚ɍl‚¦‚ç‚ê‚éB–{Œ¤‹†‚É‚¨‚¢‚ẮAˆâ“`“I‚È—vˆö‚ɂ‚¢‚Ä‚ÌŒ´ˆö‰ð–¾‚Ì‚½‚߂Ɉâ“`Žq’P—£‰ðÍAlH“I‚É”­Œ»‚³‚¹‚½ƒ^ƒ“ƒpƒNŽ¿‚Ì‹@”\‰ðÍ‚¨‚æ‚уqƒgƒ^ƒ“ƒpƒNŽ¿‚ðˆâ“`Žq‘€ì‚É‚æ‚è’u‚«Š·‚¦‚½ƒqƒgŒ^ŽÀŒ±“®•¨‚ð—p‚¢‚½Œ¤‹†‚ðs‚Á‚Ä‚¢‚éB

‚QD–ò•¨‚âŠÂ‹«‰˜õ•¨Ž¿‚̃oƒCƒIƒAƒbƒZƒC‚ÉŠÖ‚·‚錤‹†iƒnƒCƒXƒ‹[ƒvƒbƒg‘ª’è–@‚̍\’zj
@‰»Šw•¨Ž¿‚̓Ő«”­Œ»•]‰¿–@‚ɂ́AŽíX‚Ì”|—{×–E‚ð—p‚¢‚½ƒoƒCƒIƒAƒbƒZƒCŒn‚ªŽå‚ÉŽg—p‚³‚ê‚Ä‚¢‚éB–{Œ¤‹†‚É‚¨‚¢‚ẮAˆã–ò•iA”_–ò‚¨‚æ‚ъ‹«ƒzƒ‹ƒ‚ƒ““™‚̊‹«’†‚É•úo‚³‚ꂽlH‰»Šw•¨Ž¿‚ª¶‘ÔŒn‚ɂǂ̂悤‚ȉe‹¿‚ð‹y‚Ú‚·‚Ì‚©‚𖾂炩‚É‚·‚邽‚߂ɓŐ«”­Œ»•]‰¿‚ðŠÈ•Ö‚Å‚æ‚萳Šm‚ɁA‚µ‚©‚àv‘¬‚É‘ª’è‰Â”\‚È”|—{×–E‚̐lH“I‚ȍ\’z‚ðs‚Á‚Ä‚¢‚éB

‚RDˆã–ò•i‚Ì‘ãŽÓ‚¨‚æ‚Ñ•›ì—p”­Œ»—\‘ª•]‰¿Œn‚̍\’z‚ÉŠÖ‚·‚錤‹†
@ˆã–ò•i‚Ì•›ì—p‚Ì”­Œ»‚ð—\‘ª‚·‚邱‚Ƃ͏d—v‚Å‚ ‚邪A–ò•¨‚Ì‘ãŽÓŠˆ«‰»‚ªŠÖ‚í‚é•›ì—p‚Ì”­Œ»—\‘ª‚͓‚¢B‚»‚ÌŒ´ˆö‚̈ê‚‚ɖò•¨‘ãŽÓŠˆ«‚É‚Í‘å‚«‚Ȏ퍷AŒÂl·‚Ì‘¶Ý‚ª‹“‚°‚ç‚ê‚éB‚»‚±‚Å–{Œ¤‹†Žº‚ł̓qƒglH‘½”\«Š²×–EiiPS×–Ejƒ‰ƒCƒuƒ‰ƒŠ[‚ðŽ÷—§‚µA‚»‚ê‚ðˆã–ò•i‚Ì‘O—Տ°–ò•¨“®‘ÔŽŽŒ±‚ÉŒ»Ý—p‚¢‚ç‚ê‚Ä‚¢‚éƒqƒg‰‘ã”|—{×–E‚Æ“¯“™‚Ì‹@”\‚ðŽ‚Á‚½ŠÌ×–E‚ÉŒø—¦‚æ‚­•ª‰»‚³‚¹Aˆã–ò•i‚Ì‘ãŽÓ‚¨‚æ‚Ñ•›ì—p”­Œ»—\‘ª‚ª‰Â”\‚Æ‚È‚é•]‰¿Œn‚ÌŠm—§‚ð–ÚŽw‚µ‚Ä‚¢‚éB


”­•\˜_•¶
2012”N
Hepatocyte nuclear factor 6 enhances the expression of the CYP3A4 gene in hepatocyte-like cells differentiated from human induced pluripotent stem cellsa
Takamitsu Sasaki, Shogo Takahashi, Yoshihiro Numata Masayo Narita, Yutaka Tanaka, Yuki Kondo, Takeshi Kumagai, Tamihide Matsunaga, Shigeru Ohmori, Kiyoshi Nagata
Drug Metab. Pharmacokinet., in press (2012)

”sŒŒÇƒ‚ƒfƒ‹‚Æ‚µ‚Ä‚ÌTNF-alpha—U“±ŠÌ×–EŽ€‚ÆŽ_‰»ƒXƒgƒŒƒX@ƒVƒOƒiƒ‹“`’B‹@\‚©‚ç‚̃Aƒvƒ[ƒ`
âŒûC•½A‚‹´¹ŒáAŒF’J@Œ’A²X–ؐ’ŒõA‰i“c@´
ƒGƒ“ƒhƒgƒLƒVƒ“¥Ž©‘R–ƉuŒ¤‹†15@ƒGƒ“ƒhƒgƒLƒVƒ“¥Ž©‘R–ƉuŒ¤‹†‰ï•Ò, 53-57 (2012)

Mechanisms of CYP3A Induction by Glucocorticoids in Human Fetal Liver Cells
Tamihide Matsunaga, Masataka Maruyama, Tsutomu Matsubara, Kiyoshi Nagata, Yasushi Yamazoe, Shigeru Ohmori
Drug Metab. Pharmacokinet., 27, 653-657 (2012)

Effects of Hypoxia-Inducible Factor-1alpha Chemical Stabilizer, CoCl(2) and Hypoxia on Gene Expression of CYP3As in Human Fetal Liver Cells
Eiji Suzuki, Tamihide Matsunaga, Akiko Aonuma, Takamitsu Sasaki, Kiyoshi Nagata, Shigeru Ohmori
Drug Metab. Pharmacokinet., 27, 398-404 (2012)

Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane X receptor
Takeshi Kumagai, Hiroyuki Suzuki, Takamitsu Sasaki, Shuhei Sakaguchi, Shinichi Miyairi, Yasushi Yamazoe, Kiyoshi Nagata
Drug Metab. Pharmacokinet., 27, 200-206 (2012)

2011”N
Tumor Necrosis Factor-Alpha-Nuclear Factor-Kappa B-Signaling Enhances St2b2 Expression during 12-O-Tetradecanoylphorbol-13-acetate-Induced Epidermal Hyperplasia
Toshihiro Matsuda, Miki Shimada, Akira Sato, Takanori Akase, Kouichi Yoshinari, Kiyoshi Nagata, Yasushi Yamazoe
Biol. Pharm. Bull., 34, 183-190 (2011)

Progression of Alcoholic and Non-alcoholic steatohepatitis: Common Metabolic Aspects of Innate Immune System and Oxidative Stress
Shuhei Sakaguchi, Shogo Takahashi, Takamitsu Sasaki, Takeshi Kumagai, Kiyoshi Nagata
Drug Metab. Pharmacokinet., 26, 30-46 (2011)

2010”N
Malondialdehyde-modified low density lipoprotein (MDA-LDL)-induced cell growth was suppressed by polycyclic aromatic hydrocarbons (PAHs)
Hiroyuki Suzuki, Takamitsu Sasaki, Takeshi Kumagai, Shuhei Sakaguchi, Kiyoshi Nagata
J. Toxicol. Sci., 35, 137-147 (2010)

Construction of a System that Simultaneously Evaluates CYP1A1 and CYP1A2 Induction in a Stable Human-derived Cell Line using a Dual Reporter Plasmid
Wataru Sato, Hiroyuki Suzuki, Takamitsu Sasaki, Takeshi Kumagai, Shuhei Sakaguchi, Michinao Mizugaki, Shinichi Miyari, Yasushi Yamazoe, Kiyoshi Nagata
Drug Metab. Pharmacokinet., 25, 180-189 (2010)

Kinetics of 6-thioxanthine metabolism by allelic variants of xanthine oxidase
Mutsumi Kudo, Takamitsu Sasaki, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka
Drug Metab. Pharmacokinet., 25, 361-366 (2010)

Functional characterization of 26 CYP2B6 allelic variants (CYP2B6. 2-CYP2B6. 28 expect CYP2B6. 22)
Takashi Watanabe, Kaneko Sakuyama, Takamitsu Sasaki, Yuya Ishii, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka
Pharmacogenet. Genomics., 20, 459-462 (2010)

2009”N
Involvement of Vitamin D receptor in the intestinal induction of human ABCB1
Shuko Tachibana, Kouichi Yoshinari, Tsubasa Chikada, Takayoshi Toriyabe, Kiyoshi Nagata, Yasushi Yamazoe
Drug Metab. Dispos., 7, 1604-1610 (2009)

Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells: adenovirus-mediated tool for cytochrome P450 reconstitution
Kazunobu Aoyama, Kouichi Yoshinari, Hye-ji Kim, Kiyoshi Nagata, Yasushi Yamazoe
Drug Metab. Pharmacokinet., 24, 209-217 (2009)

Unveiling a new essential cis-element for the transactivation of the CYP3A4 gene by xenobiotics
Takayoshi Toriyabe, Kiyoshi Nagata,1 Tomonari Takada, Yusuke Aratsu, Tsutomu Matsubara, Kouichi Yoshinari, Yasushi Yamazoe
Mol. Pharmacol., 75, 677-684 (2009)

Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for oprotein-protein association and possible involvement of CYP3A4 J-helix in the interaction
Shuso Takeda, Yuji Ishii, Megumi Iwanaga, Arief Nurrochmad, Yuji Ito, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri, Hideyuki Yamada
Mol. Pharmacol., 75, 956-964 (2009)

Drug Metabolism Catalyzed by Cytochrome P450
Kiyoshi Nagata
Folia Pharmacol. Jpn., 134, 146-148 (2009)

2008”N
Expression of a skin cholesterol sulfotransferase, St2b2, is a trigger of epidermal cell differentiation
Miki Shimada, Toshihiro Matsuda, Akira Sato, Takamori Akase, Tsutomu Matsubara, Kiyoshi Nagata, Yasushi Yamazoe
Xenobiotica, 38, 1487-1499 (2008)

Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction in vitro and in vivo
Tsutomu Matsubara, Kouichi Yoshinari, Kazunobu Aoyama, Mika Sugawara, Yuji Sekiya, Kiyoshi Nagata, Yasushi Yamazoe
Drug Metab. Dispos., 36, 2058-2063 (2008)

Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements
Kouichi Yoshinaria, Rika Ueda, Kazutomi Kusano, Tsutomu Yoshimura, Kiyoshi Nagata, Yasushi Yamazoe
Biochem. Pharmacol., 76, 139-145 (2008)

2007”N
Assessment of Human Pregnane X Receptor Involvement in Pesticide-Mediated Activation of CYP3A4 Gene
Tsutomu Matsubara, Wachiraporn Noracharttiyapot, Takayoshi Toriyabe, Kouichi Yoshinari, Kiyoshi Nagata, Yasushi Yamazoe
Drug Metab. Dispos.. 35, 728-733 (2007)

Genetic Polymorphism of Aldehyde Oxidase in Donryu Rats
Kunio Itoh, Akiko Masubuchi, Takamitsu Sasaki, Mayuko Adachi, Nobuaki Watanabe, Kiyoshi Nagata, Yasushi Yamazoeb, Masahiro Hiratsuka, Michinao Mizugaki, Yorihisa Tanaka
Drug Metab, Dispos., 35, 734-739 (2007)

Broad but Distinct Role of Pregnane X Receptor on the Expression of Individual Cytochrome P450s in Human Hepatocytes
Koki Kojima, Kiyoshi Nagata, Tsutomu Matsubara, Yasushi Yamazoe
Drug Metab. Pharmacokinet., 22, 276-286 (2007)

Role of Human Hepatocyte Nuclear Factor 4ƒ¿ in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA
Yoshiteru Kamiyama, Tsutomu Matsubara, Kouichi Yoshinari, Kiyoshi Nagata, Hidetaka Kamimura, Yasushi Yamazoe
Drug Metab. Pharmacokinet., 22, 287-298 (2007)

Effect of Pregnane X Receptor Ligand on Pharmacokinetics of Substrates of Organic Cation Transporter Oct1 in Rats
Tomoji Maeda, Masanobu Oyabu, Takafumi Yotsumoto, Ryunosuke Higashi, Kiyoshi Nagata, Yasushi Yamazo, Ikumi Tamai
Drug Metab. Dispos., 35, 1580-1586 (2007)

Protein-Protein Interactions between Rat Hepatic Cytochromes P450 (P450s) and UDP-Glucuronosyltransferases (UGTs): Evidence for the Functionally Active UGT in P450-UGT Complex
Yuji Ishii, Megumi Iwanaga, Yoshio Nishimura, Shuso Takeda, Shin-ichi Ikushiro, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada
Drug Metab. Pharmacokinet., 22, 367-376 (2007)

Common Pathogenic Mechanism in Development Progression of Liver Injury Caused by Non-Alcoholic or Alcoholic Steatohepatitis
Kiyoshi Nagata, Hiroyuki Suzuki, Shuhei Sakaguchi
J. Toxicol. Sci., 32, 453-468, (2007)

2006”N
Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase
Masaaki Miyata, Yoshiki Matsuda, Hiroyuki Tsuchiya, Hirotaka Kitada, Takanori Akase, Miki Shimada, Kiyoshi Nagata, Frank J. Gonzalez, Yasushi Yamazoe
Drug Metab. Pharmacokinet., 21, 315-323 (2006)

Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity
Masaaki Miyata, Hirotaka Watase, Wataru Hori, Miki Shimada, Kiyoshi Nagata, Frank J. Gonzalez, Yasushi Yamazoe
Xenobiotica, 36, 631-644 (2006)

Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-{gamma} coactivator 1{alpha}
Masahiro Itoh, Miki Nakajima, Eriko Higashi, Ryoko Yoshida, Kiyoshi Nagata, Yasushi Yamazoe, Tsuyoshi Yokoi
J. Pharmacol. Exp. Ther., 319, 693-702 (2006)

Construction of several human-derived stable cell lines displaying distinct profiles of CYP3A4 induction
Wachiraporn Noracharttiyapot, Yoko Nagai, Tsutomu Matsubara, Masaaki Miyata, Miki Shimada, Kiyoshi Nagata, Yasushi Yamazoe
Drug Metab. Pharmacokinet., 21, 99-108 (2006)

Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients
Rika Goda, Daichi Nagai, Yuji Akiyama, Kiyohiro Nishikawa, Isao Ikemoto, Yoshio Aizawa, Kiyoshi Nagata, Yasushi Yamazoe
Drug Metab. Dispos., 34, 828-835 (2006)

A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes
Rika Ueda, Hiromi Iketaki, Kiyoshi Nagata, Shioko Kimura, Frank J. Gonzalez, Kazutomi Kusano, Tsutomu Yoshimura, Yasushi Yamazoe
Mol. Pharmacol., 69, 1924-1930 (2006)

Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model
Takahito Yamamoto, Akio Suzuki, Yoshiro Kohno, Kiyoshi Nagata, Yasushi Yamazoe
Curr. Drug Metab., 7, 135-146 (2006)

“ÁW1FƒAƒfƒmƒEƒCƒ‹ƒX‚ð—p‚¢‚½–ò•¨‘ãŽÓŒ¤‹†
‰i“c@´C‹à@ŒbŽ}
News Letter "Daiichi" , Spring No. 8, pp2-5 (2006)

Influences of Drugs on the Oxygen Uptake Rate and Biosorption of Activated Sludge
Takeshi Kumagai, Tatsuaki Inoue, Yuichi Mihara, Keiichi Ebina, Katsushi Yokota
Biol. Pharm. Bull., 29, 183-186 (2006)

Synthetic Peptide (P-21) Derived from Asp-Hemolysin Inhibits the Induction of Apoptosis on HUVECs by Lysophosphatidylcholine
Hiromu Tsutsumi, Takeshi Kumagai, Saori Naitoo, Keiichi Ebina, Katsushi Yokota
Biol. Pharm. Bull., 29, 907-910 (2006)

Ž_‰»Cü’á–§“xƒŠƒ|ƒ^ƒ“ƒpƒNŽ¿‚̐¶•¨Šˆ«‚Æ‚»‚ÌŠˆ«—}§ˆöŽq‚Æ‚µ‚Ä‚ÌAsp-hemolysin‚ÉŠÖ‚·‚镪Žq¶•¨Šw“IŒ¤‹†
ŒF’J@Œ’
YAKUGAKU ZASSHI, 126, 955-964 (2006)

Oxidized Low-Density Lipoprotein-Binding Specificity of the Asp-Hemolysin-Related Synthetic Peptides from Aspergillus fumigatus
Takeshi Kumagai, Hiromu Tsutsumi, Norihiro Ogawa, Saori Naito, Keiichi Ebina, Katsushi Yokota, Kiyoshi Nagata
Biol. Pharm. Bull., 29, 2181-2186 (2006)


Copyright(C)2003 TOHOKU PHARMACEUTICAL UNIVERSITY All Rights Reserved
@