東北薬科大学 ロゴマーク 東北薬科大学 東北薬科大学
薬物治療学教室
Department of Clinical Pharmacotherapeutics

〒981-8558
宮城県仙台市青葉区小松島4丁目4-1
東北薬科大学 薬物治療学教室
TEL 022-727-0112(直通)
(内線 3410, 3411, 3412, 3413)
FAX 022-727-0113
メンバー
教 授
原 明義 
准教授
菅野 秀一 
准教授
蓬田 伸
助 手
冨澤 亜也子
教室配属生(5・6年生)
28名


研究内容
わが国では、悪性新生物(がん)と心疾患が死因別死亡率の各々1位と2位を占めています。そこで当研究室では、癌細胞の生化学的研究や新しい抗がん剤および心筋保護薬の探索研究を含め、生体防御機構や薬の毒性発現機構など幅広い基礎研究を行っています。


発表論文(2006〜)



2011-2016年 論文発表
Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element.
Sasaki T, Inami K, Numata Y, Funakoshi K, Yoshida M, Kumagai T, Kanno S, Matsui S, Toriyabe T, Yamazoe Y, Yoshinari K, Nagata K.
J Pharmacol Exp Ther. 2016 Oct;359(1):102-9. doi: 10.1124/jpet.115.231589. Epub 2016 Aug 9.

Haliclonadiamine Derivatives and 6-epi-Monanchorin from the Marine Sponge Halichondria panicea Collected at Iriomote Island.
Abdjul DB, Yamazaki H, Kanno S, Takahashi O, Kirikoshi R, Ukai K, Namikoshi M.
J Nat Prod. 2016 Apr 22;79(4):1149-54. doi: 10.1021/acs.jnatprod.6b00095. Epub 2016 Apr 1.

Detecting mRNA Predictors of Acetaminophen-Induced Hepatotoxicity in Mouse Blood Using Quantitative Real-Time PCR.
Kanno S, Tomizawa A, Yomogida S.
Biol Pharm Bull. 2016;39(3):440-5. doi: 10.1248/bpb.b15-00734. Epub 2015 Dec 25.

A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.
Abdjul DB, Kanno S, Yamazaki H, Ukai K, Namikoshi M.
Bioorg Med Chem Lett. 2016 Jan 15;26(2):315-7. doi: 10.1016/j.bmcl.2015.12.022. Epub 2015 Dec 8.

Sinomenine and magnoflorine, major constituents of Sinomeni caulis et rhizoma, show potent protective effects against membrane damage induced by lysophosphatidylcholine in rat erythrocytes.
Sakumoto H, Yokota Y, Ishibashi G, Maeda S, Hoshi C, Takano H, Kobayashi M, Yahagi T, Ijiri S, Sakakibara I, Hara A
J Nat Med. 2015 Jul;69(3):441-8. doi: 10.1007/s11418-015-0907-7.

Structures and Biological Evaluations of Agelasines Isolated from the Okinawan Marine Sponge Agelas nakamurai.
Abdjul DB, Yamazaki H, Kanno S, Takahashi O, Kirikoshi R, Ukai K, Namikoshi M.
J Nat Prod. 2015 Jun 26;78(6):1428-33. doi: 10.1021/acs.jnatprod.5b00375. Epub 2015 Jun 17.

Absolute structures and bioactivities of euryspongins and eurydiene obtained from the marine sponge Euryspongia sp. collected at Iriomote Island.
Yamazaki H, Takahashi O, Kanno S, Nakazawa T, Takahashi S, Ukai K, Sumilat DA, Ishikawa M, Namikoshi M.
Bioorg Med Chem. 2015 Feb 15;23(4):797-802. doi: 10.1016/j.bmc.2014.12.049. Epub 2014 Dec 29.

Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells.
Kanno S, Kurauchi K, Tomizawa A, Yomogida S, Ishikawa M.
Toxicol Lett. 2015 Jan 22;232(2):393-402. doi: 10.1016/j.toxlet.2014.11.016. Epub 2014 Nov 18.

Acute effects of caffeine on blood pressure and heart rate in habitual and non-habitual coffee consumers: a randomized, double-blind, placebo-controlled study.
Hara A, Oide H, Miyagawa K, Takeuchi T, Nakatani Y, Yokoyama H, Amano T.
Jpn. J. Pharm. Health Care Sci. 40:383-388. (2014).

Combined effect of papuamine and doxorubicin in human breast cancer MCF-7 cells.
Syu-ichi Kanno, Shin Yomogida, Ayako Tomizawa, Hiroyuki Yamazaki, Kazuyo Ukai, Remy E. P. Mangindaan, Michio Namikoshi, Masaaki Ishikawa
Oncol. Lett., 8(2), 547-550. (2014).

Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells
Syu-ichi Kanno, Shin Yomogida, Ayako Tomizawa, Hiroyuki Yamazaki, Kazuyo Ukai, Remy E. P. Mangindaan, Michio Namikoshi, Masaaki Ishikawa
Int. J. Oncol., 43(5), 1413-9 (2013)

Exogenous albumin inhibits sorafenib-induced cytotoxicity in human cancer cell lines
Syu-ichi Kanno, Katsuyuki Itoh, Naoto Suzuki, Ayako Tomizawa, Shin Yomogida, Masaaki Ishikawa
Mol. Cli. Oncol., 1, 29-34, (2013)

Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B-cell leukemia cells
Ayako Tomizawa, Syu-ichi Kanno, Yuu Osanai, Shin Yomogida, Masaaki Ishikawa
Oncol. Lett., 6(4), 875-877, (2013)

Induction of apoptosis by a potent caffeic acid derivative, caffeic acid undecyl ester, is mediated by mitochondrial damage in NALM-6 human B cell leukemia cells
Ayako Tomizawa, Syu-ichi Kanno, Yuu Osanai, Akane Goto, Chizuru Sato, Shin Yomogida, Masaaki Ishikawa
Oncol Rep., 29(2), 425-9, (2013)

Involvement of p21waf1/cip1 expression in the cytotoxicity of the potent histone deacetylase inhibitor spiruchostatin B towards susceptible NALM-6 human B cell leukemia cells.
Kanno S, Maeda N, Tomizawa A, Yomogida S, Katoh T, Ishikawa M.
Int J Oncol. 2012 May;40(5):1391-6. (2012)

Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade.
Watanabe K, Kanno S, Tomizawa A, Yomogida S, Ishikawa M.
Oncol Rep. 2012 Jan;27(1):204-9. (2012)

Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines.
Kanno S, Kurauchi K, Tomizawa A, Yomogida S, Ishikawa M.
Toxicol Lett. 2011 Feb 5;200(3):154-61.(2011)




















Copyright(C)2003 TOHOKU PHARMACEUTICAL UNIVERSITY All Rights Reserved