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教 授 |
富田 幹雄 |
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准教授 |
伊藤 邦郎 |
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講 師 |
森本 かおり |
助手 |
石井 敬 |
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大学院 |
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6 年 |
小浦 良祐、飯田 遼、田村 直斗、我妻 雄太、石垣 洋成、工藤 麻衣、濟賀 英人、佐々木 直也、片岡 真梨奈、清水 理沙、野呂 悠佳、箱守 洋美、武藤 陽太、渡邊 大地、林 大雄 |
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5 年 |
牧野 菜生子、安藤 英美、佐野 芳美、横田 隼人、渡邉 賢司、熊谷 茉歩、宮本 将成、小山 晃平、近藤 祐也、佐藤 千彩、柏倉 正太、佐藤 博紀、高橋 昂
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| ＜研究内容＞
薬物の腸管吸収および体内動態は、経口投与製剤の有効性と安全性に大きく影響します。当教室では、飲んで効く薬の開発と適正使用に必要な技術と知識を身に付けること、クリアランス臓器（肝臓および腎臓）における薬物排泄タンパク質の機能を分子レベルにて解析し、各種疾患の適正な薬物療法の確立を目指しています。また、肝臓は薬物代謝の主要臓器であり、多くの代謝酵素が肝臓に存在しています。肝臓にける様々な薬物代謝酵素の機能を解明し、酵素の変動要因を明らかにすることを目指します。
＜研究室からのメッセージ＞
薬物動態学とは薬物輸送と薬物代謝から成る、他の理系学部にはない薬学部独自の学問です。昨今、医師・看護師・薬剤師によるチーム医療の重要性が取り上げられていますが、今後ますます高度化する医療の質を支えるのは、薬物動態学を身に付けた薬剤師です。研究室での研究成果をベットサイドに届ける研究をすることで、指導的立場になれる薬剤師を育成していくことが役目であると感じています。また、製薬企業の研究職・臨床開発職にて活躍できる人材輩出にも力を注いでいます。
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2013
Takizawa, T. Kitazato, H. Ishizaka, N. Kamiya, Y. Itoh, M. Tomita and M. Hayashi. Changes in absorption and excretion of rhodamine123 by sodium nitroprusside. Int. J. Pharm., 450; 31-35 (2013)
2012
M. Tomita, N. Doi, A. Kimura and M. Hayashi. Increases in bioavailability of poorly absorbed drug by acylcarnitine application into intestinal lumen in rats. J. Pharm. Sci., 101: 3511-3517 (2012)
Y. Takizawa, H. Kishimoto, T. Kitazato, M. Tomita and M. Hayashi. Changes in protein and mRNA expression levels of claudin family after mucosal lesion by intestinal ischemia/reperfusion. Int .J. Pharam., 426: 82-89 (2012)
2011
M. Tomita, R. Ohkubo, S. Ouch C. Kawahata and M. Hayashi. Nonlinear intestinal absorption of fluorescein isothiocyanate dextran 4,000 caused by absorptive and secretory transporting system. Pharmacol. Pharm., 2(3): 173-179 (2011)
Y. Takizawa, H. Kishimoto, T. Kitazato, M. Tomita and M. Hayashi. Effect of aminoguanidine on ischemia/reperfusion injury in rat small intestine. Biol. Pharm. Bull., 34(11): 1737-1743 (2011)
Y. Takizawa, H. Kishimoto, T. Kitazato, M. Tomita and M. Hayashi. Changes in the localization of ileal P-glycoprotein induced by intestinal ischemia/reperfusion. Biol. Pharm. Bull., 34(3): 408-414 (2011)
Y. Takizawa, H. Kishimoto, T. Kitazato, M. Tomita and M. Hayashi. Effects of antioxidants on the ischemia/reperfusion injury in rat. Eur. J. Drug Metab. Pharmacokinet., 35: 89-95 (2011)
Y. Takizawa, H. Kishimoto, T. Kitazato, M. Tomita and M. Hayashi. Effects of nitric oxide on mucosal barrier dysfunction during early phase of intestinal ischemia/reperfusion. Eur. J. Pharm. Sci., 42: 246-252 (2011)
N. Doi, M. Tomita and M. Hayashi. Absorption enhancement of acylcarnitine through changes in tight junction protein in Caco-2 Cell monolayers. Drug Metab. Pharmacokinet., 26(2); 162-170 (2011)
M. Tomita, M. Hatanaka, M. Nakaike, T. Kai, C. Kobayashi, H. Murata, A. Tanaka, A. Kanbayashi and M. Hayashi. Changes in the pharmacokinetics of rhodamine123 and bromosulfophtalein in rats treated with lipopolysaccharide. Organ Biol., 18(1): 145-150 (2011)
2010
M. Tomita, A. Kanbayashi, H. Murata, A. Tanaka, M. Nakaike, M. Hatanaka and M. Hayahsi. Effect of lipopolysaccharide on P-glycoprotein-mediated intestinal and biliary excretion of rhodamine123 in rats. Int. J. Pharm., 392: 35-41 (2010)
M. Tomita, T. Yamakawa, C. Kawahata, A. Watanabe, C. Kobayashi, A. Kanbayashi, R. Ohkubo, S. Ouchi and M. Hayashi. Regional difference of drug permeability in the rat intestine, determined using markers of the paracellular, transcellular and some transporter routes. Organ Biol. 17(1): 77-87 (2010)
M. Tomita, N. Doi, and M. Hayashi. Effects of acylcarnitines on efflux transporting system in Caco-2 cell monolayers. Eur. J. Drug Metab. Pharmacokinet., 35: 1-7 (2010)
M. Tomita, A. Watanabe, I. Fujinaga, T. Yamakawa, and M. Hayashi. Nonlinear intestinal absorption of methylprednisolone caused by absorptive and secretory transporters. Int. J. Pharm. 387: 1-6 (2010)
A single amino acid substitution confers high cinchonidine oxidation activity comparable with that of rabbit to monkey aldehyde oxidase 1, Fukiya K., Itoh K., Yamaguchi S., Kishiba A., Adachi M., Watanabe N., Tanaka Y., Drug Metab.Dispos., 38, 302-385 (2010)
2009
M. Tomita, H. Kishimoto, Y. Takizawa, and M. Hayashi. Effect of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodaimne123 in rat. Drug Metab. Pharmacokinet., 24(5): 428-437 (2009)
M. Tomita, Y. Takizawa, H. Kishimoto, and M. Hayashi. Effect of intestinal ischemia/reperfusion on P-glycoprotein mediated ileal excretion of rhodaimne123 in rat. J. Pharm. Pharmacol., 61: 1319-1324 (2009)
M. Tomita, M. Miwa, S. Ohuchi, T. Oda, J. Aketagawa, Y. Goto, and Masahiro Hayashi. Nonlinear intestinal absorption of (1→3) β-D-glucan caused by absorptive and secretory transporting system. Biol. Pharm. Bull., 32: 1295-1297 (2009)
Functional analysis of aldehyde oxidase using expressed chimeric enzyme between monkey and rat, Itoh K., Asakawa T., Hoshino K., Adachi M., Fukiya K., Watanabe N., Tanaka Y., Biol. Pharm. Bull., 32, 31-35 (2009)
Effects of selenium deficiency on aldehyde oxidase 1 in rats, Itoh K., , Adachi M., Sato J., Shouji K., Fukiya K., Fujii K., Tanaka Y., Biol. Pharm. Bull., 32, 190-194 (2009)
Individual and strain difference of aldehyde oxidase in rat, Itoh K, Yakugaku Zasshi, 129, 1487-1493 (2009)
2008
M. Tomita, N. Doi, and M. Hayashi. Effects of lauroylcarnitine and palmitoylcarnitone on transport of ranitidine in human intestinal epithelial Caco-2 cell monolayers. Organ Biology, 15(4): 377-385 (2008)
M. Tomita, Y. Takizawa, H. Kishimoto, and M. Hayashi. Assessment of ileal epithelial P-glycoprotein dysfunction induced by ischemia / reperfusion using in vivo animal model. Drug Metab. Pharmacokinet., 23(5): 356-363 (2008)
Properties of 130 kDa subunit of monkey aldehyde, Asakawa T, Itoh K, Adachi M, Hoshino K., Tanaka Y., Biol. Pharm. Bull., 31, 380-385 (2008)
Leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandinΔ13-reductase (LTB4 12-HD/PGR) responsible for reduction of a double bond of the α,β-unsaturated ketone of an aryl propionic acid non-steroidal anti-inflammatory agent CS-670, Itoh K., Yamamoto K., Adachi M., Kosaka T., Tanaka Y., Xenobiotica, 38, 249-263 (2008)
Heredity Mode of Genetic Polymorphism in Aldehyde Oxidase Activity in Donryu Strain Rats, Adachi M., Itoh K., Abe H, Tanaka Y., Xenobiotica., 38, 98-105 (2008)
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