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わが国では、がんと心疾患が死因別死亡率の各々1位と2位を占めており、これらの疾患に対する薬物療法は極めて重要な治療戦略の一つです。それとは別に、抗がん薬治療による心毒性が大きな問題となっていますが、その発現機序は不明であり予防・治療法も確立されていません。そこで当研究室では、配属学生などとともに、がんや心疾患に対して有効性・安全性の高い薬物療法を目指した基礎研究を進めています。
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著書
コンパス薬物治療学改訂第2版
原 明義（編集・共著）, 菅野秀一（共著）南江堂 (2022)
Principal Pharmacotherapy改訂3版
原 明義（共著）, 菅野秀一（共著）ネオメディカル (2022)
Principal Pharmacotherapy改訂2版
原 明義（共著）, 菅野秀一（共著）ネオメディカル (2020)
コンパス薬物治療学
原 明義（編集・共著）, 菅野秀一（共著）南江堂 (2019)
Principal Pharmacotherapy
原 明義（共著）, 菅野秀一（共著）ネオメディカル (2018)
コンパス薬理学 改訂第2版
原 明義（共著）, 菅野秀一（共著）南江堂 (2017)
医療薬学 最新薬理学 第10版
原 明義（共著）廣川書店 (2016)
イラストでみる疾病の成り立ちと薬物療法
原 明義（共著）医学評論社 (2013)
2011-2023年 論文発表
総説
コーヒーと循環器疾患 〜コーヒーは高血圧のリスク因子か？〜
原 明義
東北医科薬科大学研究誌 67, 33-39 (2020)
経口がん分子標的治療薬と食事の相互作用
菅野 秀一
医薬品相互作用研究 42, 1-8 (2018)
心臓におけるプロスタノイドの保護的役割 −受容体欠損マウスを用いた解析−
原 明義
東北医科薬科大学研究誌 63, 45-52 (2016)
原著論文
Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT.
Kanno SI, Hara A.
Toxicol In Vitro, 93,105698 (2023)
Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-κB signaling pathway.
Song W, Liang C, Sun Y, Morii S, Yomogida S, Isaji T, Fukuda T, Hang Q, Hara A, Nakano M, Gu J
J Biol Chem, 299, 103051-103051 (2023)
Overexpression of programmed cell death 1 prevents doxorubicin-induced apoptosis through autophagy induction in H9c2 cardiomyocytes.
Kanno SI, Hara A.
Cardiovasc Toxicol, 22, 462-476 (2022)
The mRNA expression of Il6 and Pdcd1 are predictive and protective factors for doxorubicin-induced cardiotoxicity.
Kanno SI, Hara A.
Mol Med Rep, 23, 113 (2021)
Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells.
Tatsuta T, Sato S, Sato T, Sugawara S, Suzuki T, Hara A, Hosono M.
Molecules. 23, E2714 (2018)
Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo.
Tatsuta T, Satoh T, Sugawara S, Hara A, Hosono M.
PLoS One. 13, e0190653 (2018)
Glutathione peroxidase 3 is a protective factor against acetaminophen?induced hepatotoxicity in vivo and in vitro.
Kanno SI, Tomizawa A, Yomogida S, Hara A.
Int J Mol Med. 40, 748-754 (2017)
Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma.
Satoh T, Tatsuta T, Sugawara S, Hara A, Hosono M.
Oncotarget. 8, 42466-42477 (2017)
Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element.
Sasaki T, Inami K, Numata Y, Funakoshi K, Yoshida M, Kumagai T, Kanno S, Matsui S, Toriyabe T, Yamazoe Y, Yoshinari K, Nagata K.
J Pharmacol Exp Ther. 359, 102-109 (2016)
Haliclonadiamine Derivatives and 6-epi-Monanchorin from the Marine Sponge Halichondria panicea Collected at Iriomote Island.
Abdjul DB, Yamazaki H, Kanno S, Takahashi O, Kirikoshi R, Ukai K, Namikoshi M.
J Nat Prod. 79, 1149-1154 (2016)
Detecting mRNA Predictors of Acetaminophen-Induced Hepatotoxicity in Mouse Blood Using Quantitative Real-Time PCR.
Kanno S, Tomizawa A, Yomogida S.
Biol Pharm Bull. 39, 440-445 (2016)
A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.
Abdjul DB, Kanno S, Yamazaki H, Ukai K, Namikoshi M.
Bioorg Med Chem Lett. 26, 315-317 (2016)
Sinomenine and magnoflorine, major constituents of Sinomeni caulis et rhizoma, show potent protective effects against membrane damage induced by lysophosphatidylcholine in rat erythrocytes.
Sakumoto H, Yokota Y, Ishibashi G, Maeda S, Hoshi C, Takano H, Kobayashi M, Yahagi T, Ijiri S, Sakakibara I, Hara A
J Nat Med. 69, 441-448 (2015)
Structures and Biological Evaluations of Agelasines Isolated from the Okinawan Marine Sponge Agelas nakamurai.
Abdjul DB, Yamazaki H, Kanno S, Takahashi O, Kirikoshi R, Ukai K, Namikoshi M.
J Nat Prod. 78, 1428-1433 (2015)
Absolute structures and bioactivities of euryspongins and eurydiene obtained from the marine sponge Euryspongia sp. collected at Iriomote Island.
Yamazaki H, Takahashi O, Kanno S, Nakazawa T, Takahashi S, Ukai K, Sumilat DA, Ishikawa M, Namikoshi M.
Bioorg Med Chem. 23, 797-802 (2015)
Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells.
Kanno S, Kurauchi K, Tomizawa A, Yomogida S, Ishikawa M.
Toxicol Lett. 232, 393-402 (2015)
Acute effects of caffeine on blood pressure and heart rate in habitual and non-habitual coffee consumers: a randomized, double-blind, placebo-controlled study.
Hara A, Oide H, Miyagawa K, Takeuchi T, Nakatani Y, Yokoyama H, Amano T.
Jpn. J. Pharm. Health Care Sci. 40, 383-388 (2014).
Combined effect of papuamine and doxorubicin in human breast cancer MCF-7 cells.
Syu-ichi Kanno, Shin Yomogida, Ayako Tomizawa, Hiroyuki Yamazaki, Kazuyo Ukai, Remy E. P. Mangindaan, Michio Namikoshi, Masaaki Ishikawa
Oncol Lett. 8, 547-550 (2014)
Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells
Syu-ichi Kanno, Shin Yomogida, Ayako Tomizawa, Hiroyuki Yamazaki, Kazuyo Ukai, Remy E. P. Mangindaan, Michio Namikoshi, Masaaki Ishikawa
Int J Oncol. 43, 1413-1419 (2013)
Exogenous albumin inhibits sorafenib-induced cytotoxicity in human cancer cell lines
Syu-ichi Kanno, Katsuyuki Itoh, Naoto Suzuki, Ayako Tomizawa, Shin Yomogida, Masaaki Ishikawa
Mol Clin Oncol. 1, 29-34 (2013)
Cytotoxic effects of caffeic acid undecyl ester are involved in the inhibition of telomerase activity in NALM-6 human B-cell leukemia cells
Ayako Tomizawa, Syu-ichi Kanno, Yuu Osanai, Shin Yomogida, Masaaki Ishikawa
Oncol Lett. 6, 875-877 (2013)
Induction of apoptosis by a potent caffeic acid derivative, caffeic acid undecyl ester, is mediated by mitochondrial damage in NALM-6 human B cell leukemia cells
Ayako Tomizawa, Syu-ichi Kanno, Yuu Osanai, Akane Goto, Chizuru Sato, Shin Yomogida, Masaaki Ishikawa
Oncol Rep. 29(2), 425-429 (2013)
Involvement of p21waf1/cip1 expression in the cytotoxicity of the potent histone deacetylase inhibitor spiruchostatin B towards susceptible NALM-6 human B cell leukemia cells.
Kanno S, Maeda N, Tomizawa A, Yomogida S, Katoh T, Ishikawa M.
Int J Oncol. 40, 1391-1396 (2012)
Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade.
Watanabe K, Kanno S, Tomizawa A, Yomogida S, Ishikawa M.
Oncol Rep. 27, 204-209 (2012)
Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines.
Kanno S, Kurauchi K, Tomizawa A, Yomogida S, Ishikawa M.
Toxicol Lett. 200, 154-161 (2011)
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