東北医科薬科大学 東北医科薬科大学
薬品物理化学教室
Laboratory of Pharmaceutical Physical Chemistry
イメージ

〒981-8558
宮城県仙台市青葉区小松島4丁目4-1
東北医科薬科大学 薬品物理化学教室
TEL 022-727-0207(研究室1)
メンバー
教 授
山口 芳樹 mail: yyoshiki*tohoku-mpu.ac.jp ← *を@に変更してください。(Please change * to @)
講 師
真鍋 法義 mail: manabe*tohoku-mpu.ac.jp ← *を@に変更してください。(Please change * to @)
助 手
大野 詩歩 mail: s.ohno*tohoku-mpu.ac.jp ← *を@に変更してください。(Please change * to @)
博士課程
Shunli Pan
薬学科
6年生 13名、5年生 12名
生命薬科学科
3年生 2名


研究内容
糖鎖の複雑性・不均一性(多様性)に興味を持ち、その機能を物理化学的手法を利用して解明しようとしています。
We are interested in the complexity and heterogeneity (diversity) of glycans and try to elucidate their functions using physicochemical methods.


発表論文(2000〜)

2021年
・NMR assignments of the N-glycans of the Fc fragment of mouse immunoglobulin G2b glycoprotein.
 Yanaka, S., Yamaguchi, Y., Takizawa, T., Miyanoiri, Y., Yogo, R., Shimada, I., and Kato, K.
 Biomol. NMR Assign., 15, 187-192, 2021.

・3D structural insights into b-glucans and their binding proteins.
 Manabe, N., and Yamaguchi, Y.
 Int. J. Mol. Sci., 22, 1578, 2021.

・Tagai, K., Ono, M., Kubota, M., Kitamura, S., Takahata, K., Seki, C., Takado, Y., Shinotoh, H., Sano, Y., Yamamoto, Y.,
 Matsuoka, K., Takuwa, H., Shimojo, M., Takahashi, M., Kawamura, K., Kikuchi, T., Okada, M., Akiyama, H., Suzuki, H.,
 Onaya, M., Takeda, T., Arai, K., Arai, N., Araki, N., Saito, Y., Trojanowski, J. Q., Lee, V. M. Y., Mishra, S. K.,
 Yamaguchi, Y., Kimura, Y., Ichise, M., Tomita, Y., Zhang, M. R., Suhara, T., Shigeta, M., Sahara, N., Higuchi, M.,
 and Shimada, H.
 High-contrast in vivo imaging of tau pathologies in Alzheimer's and non-Alzheimer's disease tauopathies.
 Neuron 109, 42-58 e48, 2021.

2020年
・Chemical synthesis of residue-selectively 13C and 2H double-isotope-labeled oligosaccharides as chemical probes for
 the NMR-based conformational analysis of oligosaccharides.
 Hamagami, H., Yamaguchi, Y., and Tanaka, H.
 J. Org. Chem., 85, 16115-16127, 2020.

・Pick's tau fibril shows multiple distinct PET probe binding sites: Insights from computational modelling.
 Mishra, S. K., Yamaguchi, Y., Higuchi, M., and Sahara, N.
 Int. J. Mol. Sci., 22, 349, 2020.

・Short disordered protein segment regulates cross-species transmission of a yeast prion.
 Shida T, Kamatari YO, Yoda T, Yamaguchi Y, Feig M, Ohhashi Y, Sugita Y, Kuwata K, Tanaka M
 Nat. Chem. Biol., 16, 756-765, 2020. doi: 10.1038/s41589-020-0516-y.

・Solid-state 17O NMR analysis of synthetically 17O-enriched D-glucosamine.
 Yamada K, Yamaguchi Y, Uekusa Y, Aoki K, Shimada I, Yamaguchi T, Kato K
 Chem. Phys. Lett., 749, 137455, 2020.

・Discovery of a new sialic acid binding region that regulates Siglec-7
 Yamakawa N, Yasuda Y, Yoshimura A, Goshima A, Crocker R P, Vergoten G, Nishiura Y, Takahashi T, Hanashima S,
 Matsumoto K, Yamaguchi Y, Tanaka H, Kitajima K, Sato C
 Sci Rep., 10, 8647, 2020.

・Molecular dynamics simulation of glycans
 Re S, Yamaguchi Y, Sugita Y
 Trends Glycosci. Glycotechnol. 32, E113-E118, 2020.

・Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite,
 galactosylated cholesterol.
 Akiyama H, Ide M, Nagatsuka Y, Sayano T, Nakanishi E, Uemura N, Yuyama K, Yamaguchi Y, Kamiguchi H, Takahashi R,
 Aerts JMFG, Greimel P, Hirabayashi Y
 J. Biol. Chem., 295(16), 5257-5277, 2020. doi: 10.1074/jbc.RA119.012502.

・Annexin A4 inhibits sulfatide-induced activation of coagulation factor XII.
 Nakayama M, Miyagawa H, Kuranami Y, Tsunooka-Ota M, Yamaguchi Y, Kojima-Aikawa K
 J. Thromb Haemost., 18, 1357-1369, 2020, doi: 10.1111/jth.14789.

・3D Structure and function of glycosyltransferases involved in N-glycan maturation
 Masamichi Nagae, Yoshiki Yamaguchi, Naoyuki Taniguchi and Yasuhiko Kizuka
 Int. J. Mol. Sci., 21(2) 437, 2020

・Structural aspects of carbohydrate recognition mechanisms of C-type lectins
 Nagae Masamichi, Yoshiki Yamaguchi
 Current Topics in Microbiology and Immunology, 429, 147-176, 2020

・A synopsis of recent developments defining how N-glycosylation impacts immunoglobulin G structure and function
 Yoshiki Yamaguchi, Adam W Barb
 Glycobiology, 30, 214-225, 2020

・有機合成化学/糖質化学は抗体-薬物複合体開発にどのように貢献できるか:
 糖鎖連結均一抗体-薬物複合体合成とがん間質ターゲティング療法の開拓
 眞鍋史乃, 山口芳樹, 松村保広
 有機合成化学協会誌, 78, 485-494, 2020.

・糖鎖立体構造解析技術の開発要素
 山口芳樹
 生化学, 92, 369-377, 2020.

2019年
・Synthesis of the core oligosaccharides of lipooligosaccharides from Campylobacter jejuni: A putative cause of Guillain-Barre
 syndrome
 Fumi Yoshida, Hiroki Yoshinaka, Hidenori Tanaka, Shinya Hanashima, Yoshiki Yamaguchi, Mikio Ishihara, Miyuki Saburomaru,
 Yuki Kato, Risa Saito, Hiromune Ando, Makoto Kiso, Akihiro Imamura, Hideharu Ishida
 Chem. Eur. J., 25, 796-805 (2019)

・Structural analysis of a novel lipooligosaccharide (LOS) from Rhodobacter azotoformans
 Yoshimi Kanie, Yoshiki Yamaguchi, Akiyoshi Hayashi, Jun Uzawa, Makoto Hatakeyama, Yasuhiro Hidaka, Nobuhiro Toda,
 Shinichiro Nakamura, Osamu Kanie
 Carbohydr Res., 473, 104-114 (2019)

・Complementary design for pairing between two types of nanoparticles mediated by a bispecific antibody: Bottom-up formation of porous materials from nanoparticles
 Teppei Niide, Noriyoshi Manabe, Hikaru Nakazawa, Kazuto Akagi, Takamitsu Hattori, Izumi Kumagai, Mitsuo Umetsu
 Langmuir, 35, 3067-3076 (2019)

・Characterization of antibody products obtained through enzymatic and nonenzymatic glycosylation reactions with a glycan
 oxazoline and preparation of a homogeneous antibody-drug conjugate via Fc N-Glycan
 Shino Manabe, Yoshiki Yamaguchi, Kana Matsumoto, Hirobumi Fuchigami, Taiji Kawase, Kenji Hirose, Ai Mitani,
 Wataru Sumiyoshi, Takashi Kinoshita, Junpei Abe, Masahiro Yasunaga, Yasuhiro Matsumura, and Yukishige Ito
 Bioconjugate Chem., 30, 1343-1355 (2019)

・Synthesis and glycan-protein interaction studies of Se-sialosides by 77Se NMR
 Tatsuya Suzuki, Chieka Hayashi, Naoko Komura, Rie Tamai, Jun Uzawa, Junya Ogawa, Hide-Nori Tanaka, Akihiro Imamura,
 Hideharu Ishida, Makoto Kiso, Yoshiki Yamaguchi, Hiromune Ando
 Org. Lett., 21, 6393-6396 (2019)

・Bisecting GlcNAc is a general suppressor of terminal modification of N-glycan
 Miyako Nakano, Sushil K. Mishra, Yuko Tokoro, Keiko Sato, Kazuki Nakajima, Yoshiki Yamaguchi, Naoyuki Taniguchi,
 Yasuhiko Kizuka
 Mol. & Cell. Proteomics, 18, 2044-2057 (2019)

・A struggle of the last eleven years after getting JSCR award
 Yoshiki Yamaguchi
 Trends Glycosci. Glycotechnol. 31, SE50-SE52, SJ50-SJ52 (2019)

・Ion mobility-mass spectrometry (IM-MS)
 Yoshiki Yamaguchi
 Glycoscience: Basic Science to Applications, pp. 6-7 (2019)

・Conformational analysis of glycans
 Yoshiki Yamaguchi
 Glycoscience: Basic Science to Applications, pp. 40-41 (2019)

・Computational science (supercomputer) and AI (artificial intelligence)
 Yoshiki Yamaguchi
 Glycoscience: Basic Science to Applications, pp. 42-43 (2019)

・Core technologies for elucidating the role of glycans in disease
 Yoshiki Yamaguchi
 Glycoscience: Basic Science to Applications, pp. 265-266 (2019)

・レクチンの糖鎖認識とは
 山口芳樹
 医学のあゆみ, 269, 750-755 (2019)

・糖鎖改変による抗体―薬物複合体合成
 眞鍋 史乃, 山口芳樹
 月刊ファインケミカル, 48, 51-59 (2019)

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