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教 授 |
山口 芳樹 mail: yyoshiki*tohoku-mpu.ac.jp ← *を@に変更してください。(Please change * to @) |
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講 師 |
真鍋 法義 mail: manabe*tohoku-mpu.ac.jp ← *を@に変更してください。(Please change * to @) |
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助 手 |
佐々木（大野）詩歩 mail: s.ohno*tohoku-mpu.ac.jp←*を@に変更してください。(Please change * to @) |
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博士課程 |
Shunli Pan, Xiao Xu、修士課程 Hsiao-Ho Chou |
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薬学科 |
6年生 11名、5年生 14名 |
生命薬科学科 |
4年生 1名、3年生 2名 |
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| 糖鎖の複雑性・不均一性（多様性）に興味を持ち、その機能を物理化学的手法を利用して解明しようとしています。 |
| We are interested in the complexity and heterogeneity (diversity) of glycans and try to elucidate their functions using physicochemical methods. |
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2023年
・Structural analysis of oligosaccharides and glycoconjugates using NMR
Yoshiki Yamaguchi, Takumi Yamaguchi, Koichi Kato
Adv. Neurobiol., 29, 163-184 (2023)
2022年
・Characterization of novel antibodies that recognize sialylated keratan sulfate and lacto-N-fucopentaose I on human induced
pluripotent cells: comparison with existing antibodies
Hiromi Nakao, Tomoko Yamaguchi, Kenji Kawabata, Katsuaki Higashi, Motohiro Nonaka, Makoto Tuiji, Yuko Nagai,
Hidenao Toyoda, Yoshiki Yamaguchi, Nobuko Kawasaki, Toshisuke Kawasaki
Glycobiology (2022)
・Synthesis of the matriglycan hexasaccharide, -3Xylα1-3GlcAβ1-trimer and its interaction with laminin
Takahiro Tamura, Yuka Omura, Kota Kotera, Ryota Ito, Shiho Ohno, Noriyoshi Manabe, Yoshiki Yamaguchi, Jun-Ichi Tamura
Org. Biomol. Chem., 20, 8489-8500 (2022)
・Analysis of selenoprotein F binding to UDP-glucose:glycoprotein glucosyltransferase (UGGT) by a photoreactive crosslinker
Sayaka Higashi, Yuki Imamura, Takashi Kikuma, Takahiro Matoba, Saya Orita, Yoshiki Yamaguchi, Yukishige Ito, Yoichi Takeda
ChemBioChem (2022)
・A data set of ion mobility collision cross sections and liquid chromatography retention times from 71 pyridylaminated N-linked
oligosaccharides
Noriyoshi Manabe, Shiho Ohno, Kana Matsumoto, Taiji Kawase, Kenji Hirose, Katsuyoshi Masuda, Yoshiki Yamaguchi
J. Am. Soc. Mass Spectrom., 33, 1772-1783 (2022)
・Functional validation of novel variants in B4GALNT1 associated with early-onset complex hereditary spastic paraplegia with
impaired ganglioside synthesis
Julian Emanuel Alecu, Yuhsuke Ohmi, Robiul H Bhuiyan, Kei-Ichiro Inamori, Takahiro Nitta, Afshin Saffari, Hellen Jumo,
Marvin Ziegler, Claudio Melo de Gusmao, Nutan Sharma, Shiho Ohno, Noriyoshi Manabe, Yoshiki Yamaguchi, Mariko Kambe,
Keiko Furukawa, Mustafa Sahin, Jin-Ichi Inokuchi, Koichi Furakawa, Darius Ebrahimi-Fakhari
Am. J. Med. Genet. A., 188, 2590-2598 (2022)
・Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A)
Masamichi Nagae, Tetsuya Hirata, Hiroaki Tateno, Sushil K Mishra, Noriyoshi Manabe, Naoko Osada, Yuko Tokoro,
Yoshiki Yamaguchi, Robert J Doerksen, Toshiyuki Shimizu, Yasuhiko Kizuka
Commun. Biol., 5, 695 (2022)
・O-Glycan-dependent interaction between MUC1 glycopeptide and MY.1E12 antibody by NMR, molecular dynamics and
docking simulations
Ryoka Kokubu, Shiho Ohno, Hirohide Kuratani, Yuka Takahashi, Noriyoshi Manabe, Hiroki Shimizu, Yasunori Chiba,
Kaori Denda-Nagai, Makoto Tsuiji, Tatsuro Irimura, Yoshiki Yamaguchi
Int. J. Mol. Sci., 23, 7855 (2022)
・Chemical and chemo-enzymatic syntheses of glycans containing ribitol phosphate scaffolding of matriglycan
Jun-Ichi Tamura, Takahiro Tamura, Shunsuke Hoshino, Rieko Imae, Ryuichi Kato, Mizuki Yokono, Mao Nagase, Shiho Ohno,
Noriyoshi Manabe, Yoshiki Yamaguchi, Hiroshi Manya, Tamao Endo
ACS Chem. Biol., 17, 1513-1523 (2022)
・High correlation among brain-derived major protein levels in cerebrospinal fluid: implication for amyloid-beta and tau protein
changes in Alzheimer's disease
Kyoka Hoshi, Mayumi Kanno, Mitsunari Abe, Takenobu Murakami, Yoshikazu Ugawa, Aya Goto, Takashi Honda, Takashi Saito,
Takaomi C Saido, Yoshiki Yamaguchi, Masakazu Miyajima, Katsutoshi Furukawa, Hiroyuki Arai, Yasuhiro Hashimoto
Metabolites, 12, 355 (2022)
2021年
・Identification of acetaldehyde-modified lysine
Ban, I., Sakake, S., Kushida, N., Manabe, N., Yamaguchi, Y., Nagai, R.
Glycative Stress Res., 8, 201-210, 2021.
・Ribitol in solution is an equilibrium of asymmetric conformations
Ohno, S., Manabe, N., Yamaguchi, T., Uzawa, J., Yamaguchi, Y.
Molecules, 26, 5471, 2021.
・Transferrin biosynthesized in the brain is a novel biomarker for Alzheimer's disease
Hoshi, K., Ito, H., Abe, E., Fuwa, T.J., Kanno, M., Murakami, Y., Abe, M., Murakami, T., Yoshihara, A., Ugawa, Y., Saito, T.,
Saido, T.C., Matsumoto, K., Yamaguchi, Y., Furukawa, K., Arai, H., Kanai, M., Miyajima, M., Arai, H., Ogawa, N., Akatsu, H.,
Hashizume, Y., Tateno, H., Honda, T., Hashimoto, Y.
Metabolites, 11, 616, 2021.
・Proteolytic processing, maturation, and unique synteny of the Streptomyces hemagglutinin SHA
Fujita-Yamaguchi, Y., Muramatsu, H., Tapia, A., Bagramyan, K., Desai, M., Takehana, Y., Igarashi, M., Yamaguchi Y., Kalkum, M.
Microbiol. Spectr., e0076621, 2021.
・Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension
Iijima, J., Hoshi, K., Ito, H., Kanno, M., Murakami, Y., Takahashi, K., Matsumoto, K., Yamaguchi, Y., Nakajima, M., Miyajima, M.,
Arai, H., Kanai, M., Kitazume, S., Honda, T., Hashimoto, Y.
Fukushima J. Med. Sci. 67, 64-70, 2021.
・Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy
Bonora, E., Chakrabarty, S., Kellaris, G., Tsutsumi, M., Bianco, F., Bergamini, C., Ullah, F., Isidori, F., Liparulo, I.,
Diquigiovanni,C., Masin, L., Rizzardi, N., Cratere, M.G., Boschetti, E., Papa, V., Maresca, A., Cenacchi, G., Casadio, R.,
Martelli, P., Matera, I., Ceccherini, I., Fato, R., Raiola, G., Arrigo, S., Signa, S., Sementa, A.R., Severino, M., Striano, P.,
Fiorillo, C., Goto, T., Uchino, S., Oyazato, Y., Nakamura, H., Mishra, S.K., Yeh, Y.S., Kato, T., Nozu, K., Tanboon, J.,
Morioka, I., Nishino, I., Toda, T., Goto, Y., Ohtake, A., Kosaki, K., Yamaguchi Y, Nonaka, I., Iijima, K., Mimaki, M.,
Kurahashi, H., Raams, A., MacInnes, A., Alders, M., Engelen, M., Linthorst, G., Koning, T.D., Dunnen W.D., Dijkstra, G.,
Spaendonck, K.V., Gent, D.C.V., Aronica, E.M., Picco, P., Carelli, V., Seri, M., Katsanis, N., Duijkers, F.A.M., Taniguchi-Ikeda M.,
Giorgio, R.D.
Brain, 144, 1451-1466, 2021.
・3D structural view of pathogen recognition by mammalian lectin receptors.
Manabe, N., Yamaguchi, Y.
Front. Mol. Biosci., 8, 670780, 2021. doi: 10.3389/fmolb.2021.670780
・Antibody glycoengineering and homogeneous antibody-drug conjugate preparation.
Manabe, S., Yamaguchi, Y.
Chem. Rec. 2021 Apr 22. doi: 10.1002/tcr.202100054.
・NMR assignments of the N-glycans of the Fc fragment of mouse immunoglobulin G2b glycoprotein.
Yanaka, S., Yamaguchi, Y., Takizawa, T., Miyanoiri, Y., Yogo, R., Shimada, I., and Kato, K.
Biomol. NMR Assign., 15, 187-192, 2021.
・3D structural insights into b-glucans and their binding proteins.
Manabe, N., and Yamaguchi, Y.
Int. J. Mol. Sci., 22(4), 1578, 2021. doi: https://doi.org/10.3390/ijms22041578
・Pick’s Tau fibril shows multiple distinct PET probe binding sites: Insights from computational modelling.
Mishra, S.K., Yamaguchi, Y., Higuchi, M, Sahara, N.
Int. J. Mol. Sci., 22(1), 349, 2021. doi: https://doi.org/10.3390/ijms22010349
・High-contrast in vivo imaging of tau pathologies in Alzheimer's and non-Alzheimer's disease tauopathies.
Tagai, K., Ono, M., Kubota, M., Kitamura, S., Takahata, K., Seki, C., Takado, Y., Shinotoh, H., Sano, Y., Yamamoto, Y.,
Matsuoka, K., Takuwa, H., Shimojo, M., Takahashi, M., Kawamura, K., Kikuchi, T., Okada, M., Akiyama, H., Suzuki, H.,
Onaya, M., Takeda, T., Arai, K., Arai, N., Araki, N., Saito, Y., Trojanowski, J. Q., Lee, V. M. Y., Mishra, S. K.,
Yamaguchi, Y., Kimura, Y., Ichise, M., Tomita, Y., Zhang, M. R., Suhara, T., Shigeta, M., Sahara, N., Higuchi, M.,
and Shimada, H.
Neuron 109, 42-58 e48, 2021.
・分岐型糖鎖の高次構造と相互作用原理の解明
山口 芳樹
BIO Clinica, 36, 79-84, 2021.
2020年
・Chemical synthesis of residue-selectively 13C and 2H double-isotope-labeled oligosaccharides as chemical probes for
the NMR-based conformational analysis of oligosaccharides.
Hamagami, H., Yamaguchi, Y., and Tanaka, H.
J. Org. Chem., 85, 16115-16127, 2020.
・Pick's tau fibril shows multiple distinct PET probe binding sites: Insights from computational modelling.
Mishra, S. K., Yamaguchi, Y., Higuchi, M., and Sahara, N.
Int. J. Mol. Sci., 22, 349, 2020.
・Short disordered protein segment regulates cross-species transmission of a yeast prion.
Shida T, Kamatari YO, Yoda T, Yamaguchi Y, Feig M, Ohhashi Y, Sugita Y, Kuwata K, Tanaka M
Nat. Chem. Biol., 16, 756-765, 2020. doi: 10.1038/s41589-020-0516-y.
・Solid-state 17O NMR analysis of synthetically 17O-enriched D-glucosamine.
Yamada K, Yamaguchi Y, Uekusa Y, Aoki K, Shimada I, Yamaguchi T, Kato K
Chem. Phys. Lett., 749, 137455, 2020.
・Discovery of a new sialic acid binding region that regulates Siglec-7
Yamakawa N, Yasuda Y, Yoshimura A, Goshima A, Crocker R P, Vergoten G, Nishiura Y, Takahashi T, Hanashima S,
Matsumoto K, Yamaguchi Y, Tanaka H, Kitajima K, Sato C
Sci Rep., 10, 8647, 2020.
・Molecular dynamics simulation of glycans
Re S, Yamaguchi Y, Sugita Y
Trends Glycosci. Glycotechnol. 32, E113-E118, 2020.
・Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite,
galactosylated cholesterol.
Akiyama H, Ide M, Nagatsuka Y, Sayano T, Nakanishi E, Uemura N, Yuyama K, Yamaguchi Y, Kamiguchi H, Takahashi R,
Aerts JMFG, Greimel P, Hirabayashi Y
J. Biol. Chem., 295(16), 5257-5277, 2020. doi: 10.1074/jbc.RA119.012502.
・Annexin A4 inhibits sulfatide-induced activation of coagulation factor XII.
Nakayama M, Miyagawa H, Kuranami Y, Tsunooka-Ota M, Yamaguchi Y, Kojima-Aikawa K
J. Thromb Haemost., 18, 1357-1369, 2020, doi: 10.1111/jth.14789.
・3D Structure and function of glycosyltransferases involved in N-glycan maturation
Masamichi Nagae, Yoshiki Yamaguchi, Naoyuki Taniguchi and Yasuhiko Kizuka
Int. J. Mol. Sci., 21(2) 437, 2020
・Structural aspects of carbohydrate recognition mechanisms of C-type lectins
Nagae Masamichi, Yoshiki Yamaguchi
Current Topics in Microbiology and Immunology, 429, 147-176, 2020
・A synopsis of recent developments defining how N-glycosylation impacts immunoglobulin G structure and function
Yoshiki Yamaguchi, Adam W Barb
Glycobiology, 30, 214-225, 2020
・有機合成化学/糖質化学は抗体-薬物複合体開発にどのように貢献できるか：
糖鎖連結均一抗体-薬物複合体合成とがん間質ターゲティング療法の開拓
眞鍋史乃, 山口芳樹, 松村保広
有機合成化学協会誌, 78, 485-494, 2020.
・糖鎖立体構造解析技術の開発要素
山口芳樹
生化学, 92, 369-377, 2020.
2019年
・Synthesis of the core oligosaccharides of lipooligosaccharides from Campylobacter jejuni: A putative cause of Guillain-Barre
syndrome
Fumi Yoshida, Hiroki Yoshinaka, Hidenori Tanaka, Shinya Hanashima, Yoshiki Yamaguchi, Mikio Ishihara, Miyuki Saburomaru,
Yuki Kato, Risa Saito, Hiromune Ando, Makoto Kiso, Akihiro Imamura, Hideharu Ishida
Chem. Eur. J., 25, 796-805 (2019)
・Structural analysis of a novel lipooligosaccharide (LOS) from Rhodobacter azotoformans
Yoshimi Kanie, Yoshiki Yamaguchi, Akiyoshi Hayashi, Jun Uzawa, Makoto Hatakeyama, Yasuhiro Hidaka, Nobuhiro Toda,
Shinichiro Nakamura, Osamu Kanie
Carbohydr Res., 473, 104-114 (2019)
・Complementary design for pairing between two types of nanoparticles mediated by a bispecific antibody: Bottom-up formation
of porous materials from nanoparticles
Teppei Niide, Noriyoshi Manabe, Hikaru Nakazawa, Kazuto Akagi, Takamitsu Hattori, Izumi Kumagai, Mitsuo Umetsu
Langmuir, 35, 3067-3076 (2019)
・Characterization of antibody products obtained through enzymatic and nonenzymatic glycosylation reactions with a glycan
oxazoline and preparation of a homogeneous antibody-drug conjugate via Fc N-Glycan
Shino Manabe, Yoshiki Yamaguchi, Kana Matsumoto, Hirobumi Fuchigami, Taiji Kawase, Kenji Hirose, Ai Mitani,
Wataru Sumiyoshi, Takashi Kinoshita, Junpei Abe, Masahiro Yasunaga, Yasuhiro Matsumura, and Yukishige Ito
Bioconjugate Chem., 30, 1343-1355 (2019)
・Synthesis and glycan-protein interaction studies of Se-sialosides by 77Se NMR
Tatsuya Suzuki, Chieka Hayashi, Naoko Komura, Rie Tamai, Jun Uzawa, Junya Ogawa, Hide-Nori Tanaka, Akihiro Imamura,
Hideharu Ishida, Makoto Kiso, Yoshiki Yamaguchi, Hiromune Ando
Org. Lett., 21, 6393-6396 (2019)
・Bisecting GlcNAc is a general suppressor of terminal modification of N-glycan
Miyako Nakano, Sushil K. Mishra, Yuko Tokoro, Keiko Sato, Kazuki Nakajima, Yoshiki Yamaguchi, Naoyuki Taniguchi,
Yasuhiko Kizuka
Mol. & Cell. Proteomics, 18, 2044-2057 (2019)
・A struggle of the last eleven years after getting JSCR award
Yoshiki Yamaguchi
Trends Glycosci. Glycotechnol. 31, SE50-SE52, SJ50-SJ52 (2019)
・Ion mobility-mass spectrometry (IM-MS)
Yoshiki Yamaguchi
Glycoscience: Basic Science to Applications, pp. 6-7 (2019)
・Conformational analysis of glycans
Yoshiki Yamaguchi
Glycoscience: Basic Science to Applications, pp. 40-41 (2019)
・Computational science (supercomputer) and AI (artificial intelligence)
Yoshiki Yamaguchi
Glycoscience: Basic Science to Applications, pp. 42-43 (2019)
・Core technologies for elucidating the role of glycans in disease
Yoshiki Yamaguchi
Glycoscience: Basic Science to Applications, pp. 265-266 (2019)
・レクチンの糖鎖認識とは
山口芳樹
医学のあゆみ, 269, 750-755 (2019)
・糖鎖改変による抗体―薬物複合体合成
眞鍋 史乃, 山口芳樹
月刊ファインケミカル, 48, 51-59 (2019)
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