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２０１９年UP
The cap‐snatching reaction of yeast L‐A double‐stranded RNA virus is reversible and the catalytic sites on both Gag and the Gag domain of Gag‐Pol are active
Tsutomu Fujimura, Rosa Esteban
Mol. Microbiol., 2019 Feb;111(2): 395-404. doi: 10.1111/mmi.14161.
Impact of water exposure on skin barrier permeability and ultrastructure
Chie Ogawa‐Fuse, Naoko Morisaki, Kyoko Shima, Mitsuyuki Hotta, Keiichi Sugata, Toshiki Ichihashi, Masashi Oguri, Osamu Yoshida, Tsutomu Fujimura
Contact Dermatitis, 2019 Apr;80(4):228-233. doi: 10.1111/cod.13174.
Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in cerebral ischemia/reperfusion injury
Masao Kishimoto, Jun Suenaga, Hajime Takase, Kota Araki, Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Ryu Ueno, Nobuyuki Shimizu, Nobutaka Kawahara, Tetsuya Yamamoto, Yoshinori Seko
Sci. Rep., 2019 Sep 18;9(1):13512. doi: 10.1038/s41598-019-50073-8.
Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G+ myeloid cells identified by exploiting histidine decarboxylase BAC-GFP transgenic mice
Jun Takai, Hiroshi Ohtsu, Atsushi Sato, Satoshi Uemura, Tsutomu Fujimura, Masayuki Yamamoto, Takashi Moriguchi
Sci. Rep., 2019 Oct 30;9(1):15603. doi: 10.1038/s41598-019-51716-6.
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２０１８年
Proton Affinitive Derivatization for Highly Sensitive Determination of Testosterone and Dihydrotestosterone in Saliva Samples by LC-ESI-MS/MS
Ken-ichi Ohno, Tomomi Hasegawa, Tomomi Tamura, Haruka Utsumi, Kouwa Yamashita
Anal. Sci., 2018 Sep 10;34(9):1017-1021. doi: 10.2116/analsci.
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２０１７年
食道がん患者の呼気に含まれる特定物質
梶山美明, 三浦芳樹, 藤村 務
生体ガス計測と高感度ガスセンシング, 2017, シーエムシー出版, 57-62.
Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1
Fumiyuki Sasaki, Tomoaki Koga, Kazuko Saeki, Toshiaki Okuno, Saiko Kazuno, Tsutomu Fujimura, Yasuyuki Ohkawa, Takehiko Yokomizo
PLoS One, 2017 Sep 18;12(9): e0185133. doi: 10.1371/journal.pone.0185133. eCollection 2017.
Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in high glucose-induced apoptosis in rat cardiac myocytes and murine pancreatic b-cells
Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Yoshinori Seko
Cells, 2017 Oct 18;6(4). pii: E35. doi: 10.3390/cells6040035.
Characteristics of hepatic insulin-sensitive nonalchoholic fatty liver disease
Fumika Shigiyama, Naoki Kumashiro, Yasuhiko Furukawa, Takashi Funayama, Kageumi Takeno, Noritaka Wakui, Takashi Ikehara, Hidenari Nagai, Hikari Taka, Tsutomu Fujimura, Hiroshi Uchino, Yoshifumi Tamura, Hirotaka Watada, Tetsuo Nemoto, Nobuyuki Shiraga, Yasukiyo Sumino, Takahisa Hirose
Hepatology Communications, 2017;1(7): 634-647.
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２０１６年
Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells
Yoko Tabe, Yasuhito Hatanaka, Mayumi Nakashiro, Kazumasa Sekihara, Shinichi Yamamoto, Hiromichi Matsushita, Saiko Kazuno, Tsutomu Fujimura, Takako Ikegami, Keita Nakanaga, Hirotaka Matsumoto, Takashi Ueno, Junken Aoki, Takehiko Yokomizo, Marina Konopleva, Michael Andreeff, Takashi Miida, Kazuhisa Iwabuchi, Keisuke Sasai
Int. J. Radiat. Biol., 2016 Jan; 92(1): 24-34. doi: 10.3109/09553002.2015.1106021. PubMed PMID: 26809544.
Protein expression profiling of giant cell tumors of bone treated with denosumab
Kenta Mukaihara, Yoshiyuki Suehara, Shinji Kohsaka, Keisuke Akaike, Yu Tanabe, Daisuke Kubota, Midori Ishii, Tsutomu Fujimura, Saiko Kazuno, Taketo Okubo, Tatsuya Takagi, Takashi Yao, Kazuo Kaneko, Tsuyoshi Saito
PLoS One, 2016 Feb 10; 11(2), e0148401, doi: 10.1371/journal.pone.0148401. eCollection 2016. PubMed PMID: 26863138.
Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation
Daisuke Yamada, Shinji Saiki, Norihiko Furuya, Kei-Ichi Ishikawa, Yoko Imamichi, Taiho Kambe, Tsutomu Fujimura, Takashi Ueno, Masato Koike, Katsuhiko Sumiyoshi, Nobutaka Hattori
Biochem. Biophys. Res. Commun., 2016 Feb; 471(1): 109-116. doi: 10.1016/j.bbrc.2016.01.171. PubMed PMID: 26851368.
Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma
Kenta Mukaihara, Yoshiyuki Suehara, Shinji Kohsaka, Daisuke Kubota, Midori Toda-Ishii, Keisuke Akaike, Tsutomu Fujimura, Eisuke Kobayashi, Takashi Yao, Marc Ladanyi, Kazuo Kaneko, Tsuyoshi Saito
BMC Cancer, 2016 Mar 10;16(1):206. doi: 10.1186/s12885-016-2235-z. PubMed PMID: 26965049; PubMed Central PMCID: PMC4787035.
Plasma levels of oxidative stress-responsive apotosis inducing protein (ORAIP) in rats subjected to physicochemical oxidative stress
Takako Yao, Tsutomu Fujimura, Kimie Murayama, Yoshinori Seko
Biosci. Rep., 2016 Mar; 36(2). pii: e00317. doi: 10.1042/BSR20160044. PubMed PMID: 26934977.
Bioinformatic identification of cytochrome b5 homologues from the parasitic nematode Ascaris suum and the free-living nematode Caenorhabditis elegans highlights the crucial role of A. suum adult-specific secretory cytochrome b5 in parasitic adaptation
Shinzaburo Takamiya, Muneaki Hashimoto, Toshihiro Mita, Takehiro Yokota, Yoshitaka Nakajima Fumiyuki Yamakura, Shigetoshi Sugio, Tsutomu Fujimura, Takashi Ueno, Hiroshi Yamasaki
Parasitol. Int., 2016 Apr; 65(2): 113-120. doi: 10.1016/j.parint.2015.11.004. PubMed PMID: 26571414.
Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids
Jorge Morales, Muneaki Hashimoto, Tom A. Williams, Hiroko Hirawake-Mogi, Takashi Makiuchi, Akiko Tsubouchi, Naoko Kaga, Hikari Taka, Tsutomu Fujimura, Masato Koike, Toshihiro Mita, Frederic Bringaud, Juan L. Concepcion, Tetsuo Hashimoto, T. Martin Embley, Takeshi Nara
Proc. Biol. Sci., 2016 May 11;283(1830). pii: 20160520. doi: 10.1098/rspb.2016.0520. PubMed PMID: 27170716; PubMed Central PMCID: PMC4874719.
Glycosylation status of serum immunoglobulin G in patients with prostate diseases
Saiko Kazuno, Jun-ichi Furukawa, Yasuro Shinohara, Kimie Murayama, Makoto Fujime, Takashi Ueno, Tsutomu Fujimura
Cancer Med., 2016 Jun; 5(6): 1137-1146. doi: 10.1002/cam4.662. PubMed PMID: 26880719.
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata, Daisuke Yasuda, Kyoko Takahashi, Tsutomu Fujimura, Jingbo Pi, Myung-Shik Lee, Takashi Ueno, Tomoyuki Ohe, Tadahiko Mashino, Toshifumi Wakai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hozumi Motohashi, Satoshi Waguri, Tomoyoshi Soga, Masayuki Yamamoto, Keiji Tanaka, Masaaki Komatsu
Nat. Commun., 2016 Jun 27;7:12030. doi:10.1038/ncmms12030. PubMed PMID: 27345495.
Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2
Kageumi Takeno, Yoshifumi Tamura, Minako Kawaguchi, Saori Kakehi, Takahiro Watanabe, Takashi Funayama, Yasuhiko Furukawa, Hideyoshi Kaga, Risako Yamamoto, Maengkyu Kim, Miho Nishitani-Yokoyama, Kazunori Shimada, Hiroyuki Daida, Shigeki Aoki, Hikari Taka, Tsutomu Fujimura, Susumu S Sawada, Adria Giacca, Akio Kanazawa, Yoshio Fujitani, Ryuzo Kawamori, Hirotaka Watada.
J. Clin. Endocrinol. Metab., 2016 Oct; 101(10): 3676-3684. PubMed PMID: 27383116.
Plasma levels of oxidative stress-responsive apotosis inducing protein (ORAIP) in patients with atrial fibrillation
Takako Yao, Kentaro Tanaka, Tsutomu Fujimura, Kimie Murayama, Shuichi Fukuda, Ko Okumura, Yoshinori Seko.
Int. J. Cardiol., 2016 Nov 1; 222: 528-530. doi: 10.1016/j.ijcard.2016.08.005. PubMed PMID: 27509221.
Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces
Fumihito Hasebe, Kenichi Matsuda, Taro Shiraishi, Yushi Futamura, Takeshi Nakano, Takeo Tomita, Ken Ishigami, Hikari Taka, Reiko Mineki, Tsutomu Fujimura, Hiroyuki Osada, Tomohisa Kuzuyama, Makoto Nishiyama.
Nature Chemical Biology, 2016 Nov; 12: 967-972. doi: 10.1038/NCHEMBIO.2181.
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２０１５年
Cysteine protease antigens cleave CD123, the a subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion.
H Nishikado, Tsutomu Fujimura, Hikari Taka, R Mineki, H Okumura, T Takai.
Biochem. Biophys. Res. Commun.., 2015 May 1; 460(2): 261-266. doi: 10.1016/j.bbrc.2015.03.022. PubMed PMID: 25778870.
Ribosomal biogenesis and translational flux inhibition by the selective inhibitor of nuclear export (SINE) XPO1 antagonist KPT-185
Yoko Tabe, Kensuke Kojima, Shinichi Yamamoto, Kazumasa Sekihara, Hiromichi Matsushita, Richard Eric Davis, Zhiqiang Wang, Wencai Ma, Jo, Ishizawa, Saiko Kazuno, Michael Kauffman, Sharon Shacham, Tsutomu Fujimura, Takashi Ueno, Takashi Miida, Michael Andreeff
PLoS One, 2015 Sep 4; 10(9): e0137210, doi: 10.1371/journal.pone.0137210. eCollection 2015. PubMed PMID: 26340096.
Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apotosis
Yoshinori Seko, Tsutomu Fujimura, Takako Yao, Hikari Taka, Reiko Mineki, Ko Okumura, Kimie Murayama
Sci. Rep., 2015 Sep 8; 5: 13737. doi: 10.1038/srep13737. PubMed PMID: 26348594.
LC-MSによる乱用薬物のグルクロン酸および硫酸抱合体分析
小松祥子
ぶんせき, 2015 Sep; 489: 400.
Recent developments of chemical derivatization in LC-MS for biomedical approaches
Ken-ichi Ohno, Kouwa Yamashita
Bioanalysis, 2015; 7: 2489-2499.
A clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines
Koichi Sugimoto, Hiroshi I Suzuki, Tsutomu Fujimura, Asami Ono, Naoko Kaga, Yasushi Isobe, Makoto Sasaki, Hikari Taka, Kohei Miyazono, Norio Komatsu
Cancer Sci., 2015 Nov; 106(11): 1534-1543. doi: 10.1111/cas.12807. PubMed PMID: 26331698.
The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression
Masako Harada, Juliana Benito, Shinichi Yamamoto, Surinder Kaur, Dirim Arslan, Santiago Ramirez, Rodrigo Jacamo, Leonidas Platanias, Hiromichi Matsushita, Tsutomu Fujimura, Saiko Kazuno, Kensuke Kojima, Yoko Tabe, Marina Konopleva
Oncotarget, 2015 Nov 10; 6(35): 37930-37947. doi: 10.18632/oncotarget.6122. PubMed PMID: 26473447.
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr-/- mouse model
Motoko Kuba, Takashi Matsuzaka, Rie Matsumori, Ryo Saito, Naoko Kaga, Hikari Taka, Kei Ikehata, Naduki Okada, Takuya Kikuchi, Hiroshi Ohno, Yoshinori Takeuchi, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Yoji Arakawa, Tsutomu Fujimura, Yoshimi Nakagawa, Naoya Yahagi, Nobuhiro Yamada, Hitoshi Shimano
Sci. Rep., 2015 Dec 1; 5: 17604. doi: 10.1038/srep17604. PubMed PMID: 26619823.
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２０１４年
An innovative LC-MS/MS-based method for determining CYP 17 and CYP 19 activity in the adipose tissue of pre- and postmenopausal and ovariectomized women using 13C-labeled steroid substrates
Toshihiko Kinoshita, Seijiro Honma, Yasuhiro Shibata, Kouwa Yamashita, Yoko Watanabe, Hitoe Maekubo, Mitsunobu Okuyama, Akiko Takashima, Naoki Takeshita
J. Clin. Endocrinol. Metab., 2014; 99, 1339-1347.
Development of a highly sensitive chemiluminescent assay for hydrogen peroxide under neutral conditions using acridinium ester and its application to an enzyme immunoassay
Hidetoshi Arakawa, Keiko Tsuruoka, Ken-ichi Ohno, Noriko Tajima, Hiromi Nagano
Luminescence, 2014; 29, 374-377.
イムノアッセイの新展開
大野賢一, 山下幸和
ぶんせき, 2014; 480, 678-682.
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２０１３年
Structure and biomimetic synthesis of novel a-pyrone polyketides of an endophytic penicillium sp. Catharanthus roses
Teigo Asai, Dan Luo, Kouwa Yamashita, Yoshiteru Oshima
Org Lett., 2013; 15(5), 1020-1023.
Benzophenones from an endophytic fungus, Graphiopsis chlorocephala, from Paeonia lactiflora cultivated in the presence of an NAD+-dependent HDAC inhibitor
Teigo Asai, Sae Otsuki, Hiroaki Sakurai, Kouwa Yamashita, Tomoji Ozeki, Yoshiteru Oshima
Org. Lett., 2013; 15(8): 2058-2061.
Structures and absolute configurations of short-branched fatty acid dimers from an endophytic fungus of Aloe arborescens
Teigo Asai, Sae Otsuki, Tohru Taniguchi, Kenji Monde, Kouwa Yamashita, Hiroaki Sakurai, Tomoji Ozeki, Yoshiteru Oshima
Tetrahedron Lett., 2013; 54(26): 3402-3405.
Preparation and structural elucidation of the phenazine-carboxylate derivative as a sensitive tag for HPLC analyses of hydroxysteroids with UV detection
Sachiko Komatsu, Yuko Mekuchi, Kouwa Yamashita, Mitsuteru Numazawa
Steroids, under review.
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２０１２年
Aromatic polyketide glycosides from an entomopathogenic fungus, Cordyceps indigotica
Teigo Asai, Takashi Yamamoto, Yu-Ming Chung, Fang-Rong Chang, Yang Chang Wu, Kouwa Yamashita, Yoshiteru Oshima
Tetrahedron Lett., 2012; 53: 277-280.
Tenuipyrone, a novel skeletal polyketide from the entomopathogenic fungus, Isaria tenuipes, cultivated in the presence of epigenetic modifiers
Teigo Asai, Yu-Ming Chung, Hiroaki Sakurai, Tomoji Ozeki, Fang-Rong Chang, Kouwa Yamashita, Yoshiteru Oshima
Org. Lett., 2012; 14: 513-515.
Development of RNA aptamer and its ligand binding assay on microchip electrophoresis
Ken-Ichi Ohno, Chikara Nakata, Yoshihiro Sano, Fumiko Nishikawa, Satoshi Nishikawa, Hidetoshi Arakawa
Curr. Chem. Genomics, 2012; 6: 1-5.
Dihydrobenzofurans as cannabinoid receptor ligands from Cordyceps annullata, an entomopathogenic fungus cultivated in the presence of an HDAC inhibitor
Teigo Asai, Dan Luo, Yutaro Obara, Tohru Taniguchi, Kenji Monde, Kouwa Yamashita, Yoshiteru Oshima
Tetrahedron Lett., 2012; 53: 2239-2243.
Biomonitoring of microcystin and aflatoxin co-occurrence in aquaculture using immunohistochemistry and genotoxicity assays
Elisabete Hiromi Hashimoto, Marcia Kamogae, Tatiana Perez Vanzella, Ilce Mara Syllus Colus, Ana Paula Frederico Rodrigues Lourenco Bracarense, Maria do Carmo Bitterncourt-Oliveria, Eiko Itano, Emilia Kiyomi Kuroda, Hajime Katoh, Satoshi Nagata, Yoshio Ueno, Ken-Ichi Harada, Elisa Yoko Hirooka
Braz. Arch. Biol. Technol., 2012; 56: 151-159.
Highly oxidized ergosterols and isariotin analogs from an entomopathogenic fungus, Gibellula formosana, cultivated in the presence of epigenetic modifying agents
Teigo Asai, Yu-Ming Chung, Hiroaki Sakurai, Tomoji Ozeki, Fang-Rong Chang, Yang-Chang Wu, Kouwa Yamashita, Yoshiteru Oshima
Tetrahedron, 2012; 68: 5817-5823.
Simultaneous enantiomeric determination of MDMA and its phase I and phase II metabolites in urine by liquid chromatography-tandem mass spectrometry with chiral derivatization
Keiko Nakanishi, Munehiro Takagi, Kei Zaitsu, Noriaki Shima, Horie Kamata, Akihiro Miki, Hajime Kato, Ken-ichi Harada, Hotoshi Tsutihashi, Koichi Suzuki
Anal. Bioanal. Chem., 2012; 404: 2427-2435.
New fluorimetric assay of horseradish peroxidase using sesamol as substrate and its application to EIA
Hidetoshi Arakawa, Shigeo Nakabayashi, Ken-Ichi Ohno, Masako Maeda
J. Pharmaceut. Anal., 2012; 2: 156-159.
Book chapter
Development of novel proton-affinitive derivatives for simultaneous analysis of testosterone and dihydrotestosterone in human serum and prostate tissue by LC-ESI-MS/MS
Kouwa Yamashita
Testosterone: Biochemistry, Therapeutic Uses and Physiological Effects: ed. by K. Chichinadze, Nova Science Publishers Inc., Chapter VIII, 2012: 145-158.
パートナー分析化学II
山下幸和
南江堂 (山口政俊, 升島 努, 能田 均編), 2012: 43-51.
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２０１１年
18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteroism
Yasuhiro Nakamura, Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Kei Takase, Celso E. Gometz-Sanchez, Seijiro Honma, Mitsunobu Okuyama, Kouwa Yamashita, William E. Rainey, Hironobu Sasano, Sadayoshi Ito
J. Clin. Endocrinol. Metab., 2011; 96: E1272-1278.
Antimicrobial activity of various antibiotics against B-9 strain that degrades microcystin produced by cyanobacteria
Ken-Ichi Harada, Hajime Kato, Kiyomi Tsuji
J. Res. Inst. Meijo. Univ., 2011; 10: 35-43.
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２０１０年
Fusaric acid as a novel proton-affinitive derivatizing reagent for highly sensitive quantification of hydroxysteroids by LC-ESI-MS/MS
Kouwa Yamashita, Keiko Yamazaki, Sachiko Komatsu, Mitsuteru Numazawa
J. Am. Soc. Mass Spectrom., 2010; 21: 249-253.
Assay of labile estrogen o-quinones, potent carcinogenic molecular species, by high performance liquid chromatography-electrospray ionization tandem mass spectrometry with phenazine derivatization
Kouwa Yamashita, Akina Masuda, Yuka Hoshino, Sachiko Komatsu, Mitsuteru Numazawa
J. Steroid Biochem. Mol. Biol., 2010; 119: 141-148.
Probing the binding pocket of the active site of aromatase with 2-phenylaliphatic androsta-1,4-diene-3,17-dione steroids
Madoka Takahashi, Kouwa Yamashita, Mitsuteru Numazawa
Steroids, 2010; 75: 330-337.
Highly sensitive and specific analysis of sterol profiles in biological samples by HPLC-ESI-MS/MS
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Kouwa Yamashita, Mitsuteru Numazawa, Yasushi Matsuzaki
J. Steroid Biochem. Mol. Biol., 2010; 121: 556-564.
Mechanism of removal of a 19-methyl group of the aromatase suicide substrates androsta-1,4-diene-3,17-dione and its 6-ene analog with human placental microsomes
Madoka Takahashi, Masao Nagaoka, Masayuki Sato, Sachiko Komatsu, Kouwa Yamashita, Mitsuteru Numazawa
Biochem. J., under review.
4- and 6-(p-Sulphamoylphenyl)androstenediones: Studies of aromatase inhibitor-based oestrone sulphatase inhibition
Yoko Watari, Satoshi Yamaguchi, Madoka Takahashi, Masao Nagaoka, Mitsuteru Numazawa
Steroids, 2010; 75: 891-896.
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