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２０１０年度以降の発表論文はこちら
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２００９年
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS
J. Lipid Res., 50, 350-357 (2009)
Akira Honda, Kouwa Yamashita, Takashi Hara, Tadashi Ikegami, Teruo Miyazaki, Mutsumi Shirai, Guorong Xu, Mitsuteru Numazawa, Yasushi Matsuzaki
Chemical aromatization of 19-hydroxyandrosta-1,4-diene-3,17-dione with acid or alkaline: Elimination of the 19-hydroxy methyl group as formaldehyde
Steroids, 74, 208-211 (2009)
Mitsuteru Numazawa, Kouwa Yamashita, Nao Kimura, Madoka Takahashi
Microdetermination of catechol estrogens by LC-ESI-MS/MS combined with picolinyl derivatization
J. Mass Spectrom. Soc., 57, 75-80 (2009)
Kouwa Yamashita, Takanori Kawahata, Madoka Takahashi, Mitsuteru Numazawa
Highly sensitive quantification of serum malonate, a possible marker for de novo lipogenesis, by LC-ESI-MS/MS
J. Lipid Res., 50, 2124-2130 (2009)
Akira Honda, Kouwa Yamashita, Tadashi Ikegami, Takashi Hara, Teruo Miyazaki, Takeshi Hirayama, Mitsuteru Numazawa, Yasushi Matsuzaki
Development of highly sensitive quantification method for testosterone and dihydrotestosterone in human serum and prostate tissue by liquid chromatography-electrospray ionization tandem mass spectrometry
Steroids, 74, 920-926 (2009)
Kouwa Yamashita, Yoshimichi Miyashiro, Hitoe Maekubo, Mitsunobu Okuyama, Seijiro Honma, Madoka Takahashi, Mitsuteru Numazawa
Aromatase inactivation by 2-substituted derivatives of the suicide substrate androsta-1,4-diene-3,17-dione
J. Steroid Biochem. Mol. Biol., 116, 191-199 (2009)
Madoka Takahashi, Wakako Handa, Hiromi Umeta, Saki Ishikawa, Kouwa Yamashita, Mitsuteru Numazawa
6b,19-Bridged androstenedione analogs as aromatase inhibitors
Steroids, 74, 884-889 (2009)
Sachiko Komatsu, Ayaka Yaguchi, Kouwa Yamashita, Masao Nagaoka, Mitsuteru Numazawa
Book chapter
薬学分析科学の最前線
じほう (日本薬学会物理系薬学部会編), 124-125 (2009)
山下幸和
薬学分析科学の最前線
じほう (日本薬学会物理系薬学部会編), 138-139 (2009)
沼澤光輝
Proton-affinitive derivatization in LC-ESI-MS/MS analyses of hydroxysteroids
Handbook on Mass Spectrometry: Instrumentation, Data and Analysis, and Application
Nova Scientific Pub. Inc., USA (J.K. Lang eds.), ISBN-978-1-60741-580-0, Chaper 18, 459-464 (2009)
Kouwa Yamashita, Mitsuteru Numazawa
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２００８年
Simultaneous determination of tetrahydrocortisol, allo-tetrahydrocortisol and tetrahydrocortisone in human urine by LC-ESI-MS/MS
Steroids, 73, 727-737 (2008)
Kouwa Yamashita, Risa Nakagawa, Mitsunobu Okuyama, Seijiro Honma, Madoka Takahashi, Mitsuteru Numazawa
Mechanistic aspects of rearrangement of 16a-Hydroxy-17-keto steroids to the 17b-hydroxy-16-keto isomers
Steroids, 73, 798-805 (2008)
Mitsuteru Numazawa, Hisao Matsuzaki, Masao Nagaoka, Kouwa Yamashita, Sachiko Komatsu, Yoshio Osawa
Development of sensitive derivatization method for aldosterone in liquid chromatography- electrospray ionization tandem mass spectrometry of corticosteroids
J. Chromatogr. A, 1200, 114-121 (2008)
Kouwa Yamashita, Mitsunobu Okuyama, Risa Nakagawa, Seijiro Honma, Fumitoshi Satoh, Ryo Morimoto, Sadayoshi Ito, Madoka Takahashi, Mitsuteru Numazawa
Preparation and structural elucidation of the picolinyl ester of aldosterone for liquid chromatography-electrospray ionization tandem mass spectrometry
Chem. Pharm. Bull., 56, 873-877 (2008)
Kouwa Yamashita, Yumiko Tadokoro, Madoka Takahashi, Mitsuteru Numazawa
Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MS
J. Lipid Res., 49, 2063-2073 (2008)
Akira Honda, Kouwa Yamashita, Hiroshi Miyazaki, Mutsumi Shirai, Tadashi Ikegami, Guorong Xu, Mitsuteru Numazawa, Takashi Hara, Yasushi Matsuzaki
Aromatization of androstenedione and 16a-hydroxyandrostenedione in human placental microsomes. Kinetic analysis of inhibition by the 19-oxygenated and 3-deoxy analogs
Steroids, 73, 1262-1269 (2008)
Mitsuteru Numazawa, Yoko Watari, Sachiko Komatsu, Kouwa Yamashita, Masao Nagaoka
Structure-activity relationships of estrogen derivatives as aromatase inhibitors. Effects of heterocyclic substituents
Chem. Pharm. Bull., 56, 1304-1309 (2008)
Mitsuteru Numazawa, Sachiko Komatsu, Takako Tominaga, Kouwa Yamashita
Review
Analysis of steroids by mass spectrometry
Rinsho Kensa, 52 (11), 1165-1175 (2008)
Seijiro Honma, Mitsunobu Okuyama, Kouwa Yamashita
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２００７年
Highly sensitive quantification of 7a-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS
Journal of Lipid Research, 48, 458-464 (2007)
Akira Honda, Kouwa Yamashita, Mitsuteru Numazawa, Tadashi Ikegami, Mikio Doy, Yasushi Matsuzaki, Hiroshi Miyazaki
Synthesis of pyridine-carboxylate derivatives of hydroxysteroids for liquid chromatography-electrospray ionization-mass spectrometry
Steroids, 72, 50-59 (2007)
Kouwa Yamashita, Sayuri Kobayashi, Satoshi Tsukamoto, Mitsuteru Numazawa
Mass spectrometric analysis of oxygenations in aromatization of androst-4- ene-3,6,17-trione,
a suicide substrate of aromatase, by placental microsomes. Isotope effect and stereochemistry.
J. Steroid Biochem. Mol. Biol., 107, 220-227 (2007)
Mitsuteru Numazawa, Madoka Takahashi, Masao Nagaoka, Wakako Handa, Kouwa Yamashita
Studies directed towards a mechanistic evaluation of inactivation of aromatase by the suicide substrates androsta-1,4-diene-3,17-diones and its 6-ene derivatives.
Aromatase inactivation by the 19-substituted derivatives and their enzymic aromatization.
J. Steroid Biochem. Mol. Biol., 107, 211-219 (2007)
Mitsuteru Numazawa, Masao Nagaoka, Wakako Handa, Yoko Ogawa, Satomi Matsuoka
Highly sensitive determination of estrone and estradiol in human serum by liquid chromatography-electrospray ionization tandem mass spectrometry
Steroids, 72, 819-827 (2007)
Kouwa Yamashita, Mitsunobu Okuyama, Yoko Watanabe, Seijirou Honma,Sayuri Kobayahsi, Mitsuteru Numazawa
Use of novel picolinoyl derivatization for simultaneous quantification of six corticosteroids by liquid chromatography-electrospray ionization tandem mass spectrometry
J. Chromatogr. A, 1173, 120-128 (2007)
Kouwa Yamashita, Madoka Takahashi, Satoshi Tsukamoto, Mitsuteru Numazawa, Mitsunobu Okuyama, Seijirou Honma
【総説】
食肉の残留ホルモン測定
月刊ホルモンと臨床, 55 (3) (2007)
本間誠次郎, 山下幸和
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２００６年
Reduction of 1,4-Dien-3-one Steroids with LiAl2H4 or NaB2H4: Stereospecific Deuterium-Labeling at the C-1a Position of a 4-En-3-one Steroid
Chem. Pharm. Bull., 54, 554-556 (2006)
Mitsuteru Numazawa, Wakako Handa, Chie Hasegawa, Madoka Takahashi
Gas Chromatography-Mass Spectrometric Study of 19-Oxygenation of the Aromatase Inhibitor 19-Methylandrostenedione with Human Placental Microsomes
Biol. Pharm. Bull., 29, 1242-1245 (2006)
Mitsuteru Numazawa, Wakako Handa
Inhibition of estrone sulfatase by aromatase inhibitor-based estrogen 3-sulfamates
Steroids, 71, 371-379 (2006)
Mitsuteru Numazawa, Takako Tominaga, Yoko Watari, Yasue Tada
Biochemical aromatization of 2-methyleneandrostenedione. Stereochemistry of hydrogen removal at the C-1 position.
J. Steroid Biochem. Molec. Biol., 101, 239-245 (2006)
Mitsuteru Numazawa, Wakako Handa, Hisao Matsuzaki
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２００５年
Aromatase Reaction of 3-Deoxyandrogens: Steric Mode of the C-19 Oxygenation and Cleavage C10-C19 Bond by Human Placental Aromatase
Biochemistry, 44, 10839-10845 (2005)
Mitsuteru Numazawa, Masao Nagaoka, Norishige Sohtome
Structure-Activity Relationships of 2-, 4-, or 6-Substituted Estrogens as Aromatase Inhibitors
J. Steroids Biochem. Molec. Biol., 96, 51-58 (2005)
Mitsuteru Numazawa, Momoko Ando, Yoko Watari, Takako Tominaga, Yasue Tada, Akiko Yoshimura
Gas Chromatography-Mass Spectrometric Analysis of Oxidative Reactions of [19,19-2H2]19-Hydroxy-3-deoxy Androgens by Placental Aromtase Absence of a Deuterium-Isotope Effect
Steroids, 70, 831-839 (2005)
Masao Nagaoka, Mitsuteru Numazawa
Determination of testosterone concentrations in rat plasma using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry combined with ethyl oxime and acetyl ester derivatization
J. Chromatogr. B., 824, 258-266 (2006)
Makoto Niwa, Noriko Watanabe, Hisashi Ochiai, Kouwa Yamashita
Structure-Activity Relationships of 2a-Substituted Androstenedione Analogs as Aromatase Inhibitors and Their Aromatization Reactions
J. Steroid Biochem. Molec. Biol., 97, 353-359 (2005)
Mitsuteru Numazawa, Wakako Handa, Chie Hasegawa, Madoka Takahashi
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２００４年
Stereochemistry of NaBH4 Reduction of a 19-Carbonyl Group of 3-Deoxy Androgens. Synthesis of [19S-3H]- and [19R-3H]-Labeled Aromatase Inhibitor Having a 19-hydroxy Group
Chem. Pharm. Bull., 52, 722-726 (2004)
Mitsuteru Numazawa, Norishige Sohtome, Masao Nagaoka
C (10)-C (19) Bond Cleavage Reaction o 19-Oxygenated Androst-4-ene-3,6-dione Steroids under Various Conditions
Chem. Pharm. Bull., 52, 983-985 (2004)
Masao Nagaoka, Mitsuteru Numazawa
Synthesis and Biochemical Properties of 6-Bromo-androstenedione Derivatives with a 2,2-Dimethyl or 2-Methyl Group as Aromatase Inhibitors
Biol. Pharm. Bull., 27, 1878-1882 (2004)
Mitsuteru Numazawa, Wakako Handa, Keiko Yamada
2,2-Dimethylandrostenedioneのアロマターゼ反応におけるメタボリックスイッチングに関する研究: 予測代謝物の合成とアロマターゼ阻害活性
東北薬科大学研究誌, 51
山田恵子, 伴田和香子, 長岡正男, 沼澤光輝
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２００３年
Kinetic Analysis of Reversible Inhibition of 16-Hydroxyandrostenedione Aromatization in Human Placental Microsomes by Suicide Substractes of Androstenedione Aromatization
Biol. Pharm. Bull., 26, 890-892 (2003)
Mitsuteru Numazawa, Ayako Mutsumi, Mii Tachibana, Akiko Yoshimura
Probing the active site of aromatase with 2-methyl-substituted androstenedione analogs
Steroids, 68, 503-512 (2003)
Mitsuteru Numazawa, Yoko Watari, Keiko Yamada, Nao Umemura, Wakako Handa
Structure-activity relationships of 3-deoxy androgens as aromatase inhibitors. Synthesis and biochemical studies of 4-substituted 4-ene and 5-ene steroids
Steroids, 68, 533-542 (2003)
Masao Nagaoka, Yoko Watari, hiromi Yajima, Kaoru Tsukioka, Yasuyo Muroi, Mitsuteru Numazawa
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２００２年
Improved Synthesis and Molecular Modeling of 4b,19-Dihydroxyandrost-5-en-17-one, an Excellent Inhibitor of Aromatase
Chem. Pharm. Bull., 50, 703-705 (2002)
Mitsuteru Numazawa, Keiko Yamada, Yoko Watari, Momoko Ando
Gastric Parietal Cells: Potent Endocrine Role in Secreting Estrogen as a Possible Regulator of Gastro-Hepatic Axis
Endocrinology, 143, 3162-3170 (2002)
Takashi Ueyama, Nobuyuki Shirasawa, Mitsuteru Numazawa, Keiko Yamada, Momoko Shelangouski, Takao Ito, Yoshihiro Tsuruo
Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rat
Food and Chemical Toxicology, 40, 925-933 (2002)
Kanako Satoh, Yoshimitsu Sakamoto, Akio Ogata, Fumiko Nagai, Hisatoshi Mikuriya, Mitsuteru Numazawa, Keiko Yamada, Naoto Aoki
Aromatization of 16a-hydroxyandrostenedione by human placental microsomes: effect of preincubation with suicide substrates of androstenedione aromatization
J. Steroid Biochem. Molec. Biol., 81, 165-172 (2002)
Mitsuteru Numazawa, Mii Tachibana, Ayako Mutsumi, Akiko Yoshimura, Yoshio Osawa
Aromatase Inhibition by 4b,5b-Epoxides of 16a-Hydroxyandrostenedione and its 19-Oxygenated Analogs, Potential Precursors of Estriol Production in the Feto-Placental Unit
Biol. Pharm. Bull., 25, 1566-1569 (2002)
Mitsuteru Numazawa, Akiko Yoshimura, Yoko Watari, Hisao Matsuzaki
Studies on the Catalytic Function of Aromatase: Aromatization of 6-Alkoxy-Subtituted Androgens
J. Steroid Biochem. Molec. Biol., 82, 65-73 (2002)
Mitsuteru Numazawa, Momoko Ando, Rika Zennyozi
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２００１年
19-Oxygenation of C19-Steroids with an A,B-Ring Enone Structure, Competitive Inhibitors of Estrogen Biosynthesis, with Human Placental Aromatase
Biol. Pharm. Bull., 24, 322-335 (2001)
Mitsuteru Numazawa, Keiko Yamada, Masao Nagaoka
Gas Chromatography-Mass Spectrometric Determination of Activity of Human Placental Aromatase Using 16a-Hydroxyandrostenedione as a Substrate
Biol. Pharm. Bull., 24, 564-566
Mitsuteru Numazawa, Akiko Yoshimura, Masao Nagaoka
Identification of 16a,19-Dihydroxyandrostenedione in the Serum of Pregnant Women by Gas Chromatography-Mass Spectrometry
Biol. Pharm. Bull., 24, 947-949 (2001)
Mitsuteru Numazawa, Satoshi Satoh, Masao Nagaoka, Hideo Honjo, Yoshio Osawa
Production of 16b-(acetoxy)acetoxy derivatives by reaction of 17-keto steroid enol acetates with lead (IV) acetate
Steroids, 66, 743-748 (2001)
Mitsuteru Numazawa, Momoko Shelangouski, Masamichi Nakakoshi
Role of Hydrophilic Interaction in Binding of Hydroxylated 3-Deoxy C19 Steroids to the Active Site of Aromatase
J. Med. Chem., 44, 4277-4283 (2001)
Mitsuteru Numazawa, Keiko Yamada, Syoko Nitta, Chika Sasaki, Kanae Kidokoro
Time-dependent aromatase inactivation by 4,5-epoxides of the natural substrate androstenedione and its 19-oxygenated analogs
Steroids, 67, 185-193 (2001)
Mitsuteru Numazawa, Akiko Yoshimura, Mii Tachibana, Momoko Shelangouski, Maya Ishikawa
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２０００年
Formation of 17b-Alkoxy-16-keto Steroids by Reaction of 16a-Hydroxy-17-keto and 17b-Hydroxy-16-keto Steroids with Trimethylsilyl Iodide in the Presence of Alkyl Alcohols
Chem. Pharm. Bull., 48, 1215-1218 (2000)
Masao Nagaoka, Michiko Endo, Mitsuteru Numazawa
Synthesis and Biochemical Studies of 19-Oxygenated Derivatives of 6a- and 6b-Methylandrostenediones as Catalytic Probes for Active Site of Aromatase
Biol. Pharm. Bull., 23, 1059-1065 (2000)
Mitsuteru Numazawa, Akiko Yoshimura
Synthesis of 19-Oxygenated 4b,5b-Epoxy Derivatives of 16a-Hydroxyandrostenedione as Mechanistic and Catalytic Probes for Aromatase Reaction
Chem. Pharm. Bull., 48, 1359-1362 (2000)
Mitsuteru Numazawa, Akiko Yoshimura
Probing the Binding Pocket of the Active Site of Aromatase with 6-Ether or 6-Ester Substituted Androst-4-ene-3,17-diones and Their Diene and Triene Analogs
Steroids, 65, 871-882 (2000)
Mitsuteru Numazawa, Momoko Shelangouski, Mina Nagasawa
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