Division of Glyco-Signal Research, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University
Mitoma, J. and Fukuda, M. Core O-glycans required for lymphocyte homing: gene knockout mice of core 1 beta1,3-N-acetylglucosaminyltransferase and core 2 N-acetylglucosaminyltransferase. Methods in Enzymology (2010) in press.
Mitoma, J., Miyazaki, T., Sutton-Smith, M., Suzuki, M., Saito, H., Yeh, J. C., Kawano, T., Hindsgaul, O., Seeberger, P. H., Panico, M., Haslam, S. M., Morris, H. R., Cummings, R. D., Dell, A., and Fukuda, M. The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cells. Glycoconj. J. (2009) 26(5), 511
Mitoma, J. Oligosaccharides in lymphocyte homing. Tanpakushitu Kakusan Koso (2008) 53(12), 1598
Mitoma, J. Structural basis of oligosaccharides for L-selectin-mediated lymphocyte homing. Trends Glycosci. Glycotech. (2007) 19, 257
Mitoma, J., Bao, X., Petryanik, B., Schaerli, P., Gauguet, J. M., Yu, S. Y., Kawashima, H., Saito, H., Ohtsubo, K., Marth, J. D., Khoo, K. H., von Andrian, U. H., Lowe, J. B., and Fukuda, M. Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment, Nat Immunol (2007) 8(4), 409
Hiraoka, N., Petryniak, B., Kawashima, H., Mitoma, J., Akama, T. O., Fukuda, M. N., Lowe, J. B., and Fukuda, M. Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing, Glycobiology (2007) 17(3), 277
Mitoma, J., and Fukuda, M. Expression of specific carbohydrates by transfection with carbohydrate modifying enzymes, Methods Enzymol. (2006) 416, 293
Higashi, H., and Ito, M. (2006) Analysis of sugar chain structures using an endoglycoceramidase. Endo, M., Yamamoto, K., Takagaki, K., and Hase, S. (eds). Endoglycosidases - Biochemistry, Biotechnology, Application, Kodansha, Springer, Tokyo, Heidelberg
Cabrera, P. V., Amano, M., Mitoma, J., Chan, J., Said, J., Fukuda, M., and Baum, L. G. Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death, Blood (2006) 108(7), 2399
Angata, K., Lee, W., Mitoma, J., Marth, J. D., and Fukuda, M. Cellular and molecular analysis of neural development of glycosyltransferase gene knockout mice, Methods Enzymol. (2006) 417, 25
Wang, L., Mitoma, J., Tsuchiya, N., Narita, S., Horikawa, Y., Habuchi, T., Imai, A., Ishimura, H., Ohyama, C., and Fukuda, M. An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer, Biochem. Biophys. Res. Commun. (2005) 331(4), 958
Nakagawa, T., Morotomi, A., Tani, M., Sueyoshi, N., Komori, H., and Ito, M. C18:3-GM1a induces apoptosis in Neuro2a cells: enzymatic remodeling of fatty acyl chains of glycosphingolipids, J. Lipid Res. (2005) 46(6), 1103
Kawashima, H., Petryniak, B., Hiraoka, N., Mitoma, J., Huckaby, V., Nakayama, J., Uchimura, K., Kadomatsu, K., Muramatsu, T., Lowe, J. B., and Fukuda, M. N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules, Nat Immunol (2005) 6(11), 1096
Hwang, Y. H., Tani, M., Nakagawa, T., Okino, N., and Ito, M. Subcellular localization of human neutral ceramidase expressed in HEK293 cells, Biochem. Biophys. Res. Commun. (2005) 331(1), 37
Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., and Hirabayashi, Y. Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality, J. Biol. Chem. (2004) 279(5), 3573
Shimizu, M., Furuya, S., Shinoda, Y., Mitoma, J., Okamura, T., Miyoshi, I., Kasai, N., Hirabayashi, Y., and Suzuki, Y. Functional analysis of mouse 3-phosphoglycerate dehydrogenase (Phgdh) gene promoter in developing brain, J. Neurosci. Res. (2004) 76(5), 623
Sato, F., Nakagawa, T., Ito, M., Kitagawa, Y., and Hattori, M. A. Application of RNA interference to chicken embryos using small interfering RNA, J Exp Zoolog A Comp Exp Biol (2004) 301(10), 820
Mitoma, J., Furuya, S., Shimizu, M., Shinoda, Y., Yoshida, K., Azuma, N., Tanaka, H., Suzuki, Y., and Hirabayashi, Y. Mouse 3-phosphoglycerate dehydrogenase gene: genomic organization, chromosomal localization, and promoter analysis, Gene (2004) 334, 15
Kobayashi, M., Mitoma, J., Nakamura, N., Katsuyama, T., Nakayama, J., and Fukuda, M. Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori, Proc. Natl. Acad. Sci. U. S. A. (2004) 101(51), 17807
Hiraoka, N., Kawashima, H., Petryniak, B., Nakayama, J., Mitoma, J., Marth, J. D., Lowe, J. B., and Fukuda, M. Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing, J. Biol. Chem. (2004) 279(4), 3058
Higashi, H., and Chen, N. H. Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization, Glycoconj. J. (2004) 20(1), 49
Yasuda, H., Higashi, H., Kudo, Y., Inoue, T., Hata, Y., Mikoshiba, K., and Tsumoto, T. Imaging of calcineurin activated by long-term depression-inducing synaptic inputs in living neurons of rat visual cortex, Eur. J. Neurosci. (2003) 17(2), 287
Mitoma, J., Petryniak, B., Hiraoka, N., Yeh, J. C., Lowe, J. B., and Fukuda, M. Extended core 1 and core 2 branched O-glycans differentially modulate sialyl Lewis X-type L-selectin ligand activity, J. Biol. Chem. (2003) 278(11), 9953
Ito, M., Tani, M., and Nakagawa, T. [Recruitment of the neutral ceramidase to plasma membranes as a type II integral membrane protein by O-glycosylation of mucin-like domain--new technology for conversion of soluble proteins to type II integral proteins of plasma membranes], Tanpakushitsu Kakusan Koso. (2003) 48(8 Suppl), 1171
Chen, N., Furuya, S., Shinoda, Y., Yumoto, M., Ohtake, A., Sato, K., Doi, H., Hashimoto, Y., Kudo, Y., and Higashi, H. Extracellular carbohydrate-signal triggering cAMP-dependent protein kinase-dependent neuronal actin-reorganization, Neuroscience (2003) 122(4), 985
Chen, N., Furuya, S., Doi, H., Hashimoto, Y., Kudo, Y., and Higashi, H. Ganglioside/calmodulin kinase II signal inducing cdc42-mediated neuronal actin reorganization, Neuroscience (2003) 120(1), 163
Furuya, S., Mitoma, J., and Hirabayashi, Y. [Glia-derived L-Ser regulating survival development and lipid synthesis of developing central neurons], Tanpakushitsu Kakusan Koso - Protein, Nucleic Acid, Enzyme (2002) 47(4 Suppl), 409
Yamasaki, M., Yamada, K., Furuya, S., Mitoma, J., Hirabayashi, Y., and Watanabe, M. 3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain, J. Neurosci. (2001) 21(19), 7691
Sugishita, H., Kuwabara, Y., Toku, K., Doi, L., Yang, L., Mitoma, J., Furuya, S., Hirabayashi, Y., Maeda, N., Sakanaka, M., and Tanaka, J. L-Serine regulates the activities of microglial cells that express very low level of 3-phosphoglycerate dehydrogenase, an enzyme for L-Serine biosynthesis, J. Neurosci. Res. (2001) 64(4), 392
Horibata, Y., Higashi, H., and Ito, M. Transglycosylation and Reverse Hydrolysis Reactions of Endoglycoceramidase from the Jellyfish, Cyanea nozakii, J. Biochem. (Tokyo). (2001) 130(2), 263
Higashi, H., Chen, N., and Hashimoto, Y. Neuronal Actin-Spike Formation Under Local PKA Activation By Glyco-Signal Through Cell-Surface N-Acetylgalactosamine Receptor, J. Neurochem. (2001) 78(Suppl. 1), 34
Division of Glyco-Signal Research
Institute of Molecular Biomembrane and Glycobiology Japanese Tohoku Pharmaceutical University Information Research Member Top Page Publication Lecture Link
1991-2000  -1990