PUBLICATIONS2-E

Publications

Katayama, Y., Ohuchi, Y., Higashi, H., Kudo, Y., and Maeda, M. The design of cyclic AMP--recognizing oligopeptides and evaluation of its capability for cyclic AMP recognition using an electrochemical system, Anal. Chem. (2000) 72(19), 4671

Hama, T., Higashi, H., and Maruyama, M. (2000) Lasalocid induces cell death on NG108-15 cells. Kato, T. (ed). Frontiers of the Mechanisms of Memory and Dementia, Elsevier Science B.V.

Furuya, S., Tabata, T., Mitoma, J., Yamada, K., Yamasaki, M., Makino, A., Yamamoto, T., Watanabe, M., Kano, M., and Hirabayashi, Y. L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons, Proc. Natl. Acad. Sci. U. S. A. (2000) 97(21), 11528

Nakagawa, T., Tani, M., Kita, K., and Ito, M. Preparation of fluorescence-labeled GM1 and sphingomyelin by the reverse hydrolysis reaction of sphingolipid ceramide N-deacylase as substrates for assay of sphingolipid-degrading enzymes and for detection of sphingolipid-binding proteins, J. Biochem. (Tokyo). (1999) 126(3), 604

Mitoma, J., Furuya, S., and Hirabayashi, Y. [A novel metabolic interaction between neurons and glial cells through L-serine: an essential role for astroglia-derived L-serine in the survival and development of CNS neurons], Seikagaku - Journal of Japanese Biochemical Society (1999) 71(7), 536

Tani, M., Kita, K., Komori, H., Nakagawa, T., and Ito, M. Enzymatic synthesis of omega-amino-ceramide: preparation of a sensitive fluorescent substrate for ceramidase, Anal. Biochem. (1998) 263(2), 183

Mitsutake, S., Kita, K., Nakagawa, T., and Ito, M. Enzymatic synthesis of 14C-glycosphingolipids by reverse hydrolysis reaction of sphingolipid ceramide N-deacylase: detection of endoglycoceramidase activity in a seaflower, J. Biochem. (Tokyo). (1998) 123(5), 859

Mitoma, J., Kasama, T., Furuya, S., and Hirabayashi, Y. Occurrence of an unusual phospholipid, phosphatidyl-L-threonine, in cultured hippocampal neurons. Exogenous L-serine is required for the synthesis of neuronal phosphatidyl-L-serine and sphingolipids, J. Biol. Chem. (1998) 273(31), 19363

Mitoma, J., Ito, M., Furuya, S., and Hirabayashi, Y. Bipotential roles of ceramide in the growth of hippocampal neurons: promotion of cell survival and dendritic outgrowth in dose- and developmental stage-dependent manners, J. Neurosci. Res. (1998) 51(6), 712

Mitoma, J., Furuya, S., and Hirabayashi, Y. A novel metabolic communication between neurons and astrocytes: non-essential amino acid L-serine released from astrocytes is essential for developing hippocampal neurons, Neurosci. Res. (1998) 30(2), 195

Kuroda, R., Ikenoue, T., Honsho, M., Tsujimoto, S., Mitoma, J. Y., and Ito, A. Charged amino acids at the carboxyl-terminal portions determine the intracellular locations of two isoforms of cytochrome b5, J. Biol. Chem. (1998) 273(47), 31097

Kudo, Y., Morita, M., and Higashi, H. (1998) Visualization of kinase activity in the living cells. Kanno, T., Nakazawa, Y., and Kumakura, K. (eds). The Adrenal Chromaffin Cell, Hokkaido University Press, Sapporo

Honsho, M., Mitoma, J. Y., and Ito, A. Retention of cytochrome b5 in the endoplasmic reticulum is transmembrane and luminal domain-dependent, J. Biol. Chem. (1998) 273(33), 20860

Furuya, S., Mitoma, J., Makino, A., and Hirabayashi, Y. Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells, J. Neurochem. (1998) 71(1), 366

Katayama, Y., Ohuchi, Y., Nakayama, M., Maeda, M., Higashi, H., and Kudo, Y. Cyclic AMP detection by electrode modified with 17mer oligopeptide, Chemistry Letters (1997) 1997, 883

Higashi, H., Sato, K., Ohtake, A., Omori, A., Yoshida, S., Kudo, Y., and Nagai, Y. Saccharide specificity and mechanism for glycoconjugate-mediated activation of cyclic AMP-dependent protein kinase in neural cells, Glycoconj. J. (1997) 14(4), S10

Higashi, H., Sato, K., Ohtake, A., Omori, A., Yoshida, S., and Kudo, Y. Imaging of cAMP-dependent protein kinase activity in living neural cells using a novel fluorescent substrate, FEBS Lett. (1997) 414(1), 55

Nagatsuka, Y., Yamaki, M., Watarai, S., Yasuda, T., Higashi, H., Yamagata, T., and Ono, Y. The Epstein-Barr virus (EBV) alters the B cell glycolipid which is recognized by the human monoclonal antibody to i-blood group antigen, Virus Res. (1996) 43(1), 57

Kuroda, R., Kinoshita, J., Honsho, M., Mitoma, J., and Ito, A. In situ topology of cytochrome b5 in the endoplasmic reticulum membrane, J. Biochem. (Tokyo). (1996) 120(4), 828

Higashi, H., Yoshida, S., Sato, K., and Yamagata, T. Interaction of ganglioside with specific peptide sequences as a mechanism for the modulation of calmodulin-dependent enzymes, J. Biochem. (Tokyo). (1996) 120, 66

Higashi, H., Sato, K., Omori, A., Sekiguchi, M., Ohtake, A., and Kudo, Y. Imaging of Ca2+ /calmodulin-dependent protein kinase II activity in hippocampal neurons, Neuroreport (1996) 7, 2695

Nagatsuka, Y., Watarai, S., Yasuda, T., Higashi, H., Yamagata, T., and Ono, Y. Production of human monoclonal antibodies to i blood group by EBV-induced transformation: Possible presence of a new glycolipid in cord red cell membranes and human hematopoietic cell lines, Immunol. Lett. (1995) 46(1-2), 93

Higashi, H., and Kudo, Y. Regulation by gangliosides of calcium/calmodulin-dependent protein phosphorylation and dephosphorylation in living cells, Glycoconj. J. (1995) 12(4), 554

Maru, M., Haraguchi, M., Higashi, H., Kato, S., Kurimura, T., Naiki, M., and Wakamiya, N. Anti-Tumor Activity of Ceramides and Glycosphingolipids in a Murine Tumor System., Int. J. Cancer (1993) 53, 645

Higashi, H., Yoshida, S., Sato, K., and Yamagata, T. Modulation of calmodulin-dependent enzymes by gangliosides through binding to their specific polypeptide sequences., Glycoconj. J. (1993) 10(4), 242

Mitoma, J., and Ito, A. The carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum, EMBO J. (1992) 11(11), 4197

Mitoma, J., and Ito, A. Mitochondrial targeting signal of rat liver monoamine oxidase B is located at its carboxy terminus, J. Biochem. (Tokyo). (1992) 111(1), 20

Higashi, H., and Yamagata, T. Mechanism for ganglioside-mediated modulation of calmodulin-dependent enzyme. Modulation of calmodulin-dependent cyclic nucleotide phosphodiesterase activity through the binding of gangliosides to calmodulin and the enzyme., J. Biol. Chem. (1992) 267, 9839

Higashi, H., and Yamagata, T. Full activation without calmodulin of calmodulin-dependent cyclic nucleotide phosphodiesterase by acidic glycosphingolipids; GM3, sialosylneolactotetraosylceramide and sulfatide, FEBS Lett. (1992) 314(1), 53

Higashi, H., Omori, A., and Yamagata, T. Calmodulin, a ganglioside-binding protein. Binding of gangliosides to calmodulin in the presence of calcium., J. Biol. Chem. (1992) 267, 9831

Kawai, T., Kato, A., Higashi, H., Kato, S., and Naiki, M. Quantitative determination of N-glycolylneuraminic acid expression in human cancerous tissues and avian lymphoma cell lines as a tumor-associated sialic acid by gas chromatography-mass spectrometry, Cancer Res. (1991) 51(4), 1242

Akao, T., Osaki, T., Mitoma, J., Ito, A., and Kunitake, T. Correlation between physicochemical characteristics of synthetic cationic amphiphiles and their DNA transfection ability, Bull. Chem. Soc. Jpn. (1991) 64, 3677

Akao, T., Osaki, T., Mitoma, J., Ito, A., and Kunitake, T. The effect of physico-chemical characteristics of synthetic cationic amphiphiles on DNA transfection, Chemistry Letters (1991), 311

1991-2000