2015～

2022年

TRPV4 activation prevents lipopolysaccharide-induced painful bladder hypersensitivity in rats by regulating immune pathways.
Masaru Yoshizumi, Naoya Tazawa, Chizuko Watanabe, Hirokazu Mizoguchi.
Front. Immunol., 13: 1080302, 2022

Translational value of the transdermal administration of bergamot essential oil and of its fractions.
Damiana Scuteri, Laura Rombola, Michele Crudo, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Luigi Antonio Morrone, Paolo Tonin, Giacinto Bagetta, Maria Tiziana Corassaniti.
Pharmaceutics., 14: 1006, 2022

Preclinical characterization of antinociceptive effect of bergamot essential oil and of its fractions for rational translation in complementary therapy.
Damiana Scuteri, Laura Rombola, Michele Crudo, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Paolo Tonin, Maria Tiziana Corassaniti, Giacinto Bagetta.
Pharmaceutics., 14: 312, 2022

Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
Keita Ito, Noriki Kutsumura, Yasuyuki Nagumo, Tsuyoshi Saitoh, Akihisa Tokuda, Kao Hashimoto, Naoshi Yamamoto, Ryoji Kise, Asuka Inoue, Hirokazu Mizoguchi, Hiroshi Nagase.
Bioorg. Med. Chem. Lett., 56: 128485, 2022

2021年

Development and translation of nanoBEO, a nanotechnology-based delivery system of bergamot essential oil deprived of furocumarins, in the control of agitation in severe dementia.
Damiana Scuteri, Rosaria Cassano, Sonia Trombino, Rossella Russo, Hirokazu Mizoguchi, Chizuko Watanabe, Kengo Hamamura, Soh Katsuyama, Takaaki Komatsu, Luigi Antonio Morrone, Laura Rombola, Annagrazia Adornetto, Annarita S. Lagani, Maria Tiziana Corassaniti, Paolo Tonin, Shinobu Sakurada, Tsukasa Sakurada, Pierluigi Nicotera, Giacinto Bagetta.
Pharmaceutics., 13: 379, 2021

Gabapentin reduces painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis.
Masaru Yoshizumi, Chizuko Watanabe, Hirokazu Mizoguchi.
Pharmacol. Res. Perspect., 9: e00697, 2021

Central mechanisms of apomorphine and m-chlorophenylpiperazine on synergistic action for ejaculation in rats.
Masaru Yoshizumi, Akihiko Yonezawa, Yukio Kimura, Chizuko Watanabe, Shinobu Sakurada, Hirokazu Mizoguchi.
J. Sex. Med., 18: 231-239, 2021

2020年

Exploring μ-opioid receptor splice variants as specific molecular target for new analgesics.
Hirokazu Mizoguchi, Hideaki Fujii.
Curr. Top. Med. Chem., 20: 2866-2877, 2020

Morphine antinociception restored by use of methadone in the mophine-resistant inflammatory pain state.
Chizuko Watanabe, Asami Komiyama, Masaru Yoshizumi, Shinobu Sakurada, Hirokazu Mizoguchi.
Front. Pharmacol., 11: 593647, 2020

Effectiveness of gabapentinoids for cancer-related rectal and vesical tenesmus: Report of four cases.
Keita Tagami, Masaru Yoshizumi, Akira Inoue, Motohiro Matoba.
Indian. J. Palliat. Care., 26: 381-384, 2020

2019年

Neuropharmacological properties of the essential oil of bergamot for the clinical management of pain-related BPSDs.
Damiana Scuteri, Laura Rombola, Laura Tridico, Hirokazu Mizoguchi, Chizuko Watanabe, Tsukasa Sakurada, Shinobu Sakurada, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone.
Curr. Med. Chem., 26: 3764-3774, 2019

Anxiolytic-like effects of bergamot essential oil are insensitive to flumazenil in rats.
Laura Rombola, Damiana Scuteri, Annagrazia Adornetto, Marilisa Straface, Tsukasa Sakurada, Shinobu Sakurada, Hirokazu Mizoguchi, Maria Tiziana Corasaniti, Giacinto Bagetta, Paolo Tonin, Luigi Antonio Morrone.
Evid. Based. Complement. Alternat. Med., ID2156873: 6, 2019

2018年

Antinociceptive effect of inhalation of the essential oil of bergamot in mice.
Damiana Scuteri, Michele Crudo, Laura Rombola, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Tsukasa Sakurada, Rosaria Greco, Maria Tiziana Corasaniti, Luigi Antonio Morrone, Giacinto Bagetta.
Fitoterapia, 129: 20-24, 2018

2017年

The involvement of spinal release of histamine on nociceptive behaviors induced by intrathecally administered spermine.
Hirokazu Mizoguchi, Chizuko Watanabe, Takafumi Hayashi, Yoko Iwata, Hiroyuki Watanabe, Soh Katsuyama, Kengo Hamamura, Tsukasa Sakurada, Hiroshi Ohtsu, Kazuhiko Yanai, Shinobu Sakurada.
Eur. J. Pharmacol., 800: 9-5, 2017

Bergamot essential oil attenuates anxiety-like behaviour in rats.
Laura Rombolà, Laura Tridico, Damiana Scuteri, Tsukasa Sakurada, Shinobu Sakurada, Hirokazu Mizoguchi, Pinarosa Avato, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone.
Molecules, 22: E614, 2017

Opioids resistance in chronic pain management.
Luigi Antonio Morrone, Damiana Scuteri, Laura Rombolà, Hirokazu Mizoguchi, Giacinto Bagetta.
Curr. Neuropharmacol., 15: 444-456, 2017

2016年

Intrathecal morphine-3-glucuronide-induced nociceptive behavior via δ2 opioid receptors in the spinal cord.
Takaaki Komatsu, Soh Katsuyama, Hiroshi Nagase, Hirokazu Mizoguchi, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada.
Pharmacol. Biochem. Behav., 140: 68-74, 2016

Involvement of spinal glutamate in nociceptive behavior induced by intrathecal administration of hemokinin-1 in mice.
Chizuko Watanabe, Hirokazu Mizoguchi, Giacinto Bagetta, Shinobu Sakurada.
Neurosci. Lett., 617: 236-239, 2016

Analgesic effects of 1st generation anti-histamines in mice.
Mebae Takahashi, Kazuhiko Shima, Masahiro Tsuchiya, Yoshihiro Hagiwara, Hirokazu Mizoguchi, Shinobu Sakurada, Shunji Sugawara, Takuo Fujita, Takeshi Tadano, Makoto Watanabe, Satoshi Fukumoto, Yauo Endo.
Biol. Pharm. Bull., 39: 620-624, 2016

The involvement of central nervous system histamine receptors in psychological stress-induced exacerbation of allergic airway inflammation in mice.
Tomomitsu Miyasaka, Kaori Okuyama-Dobashi, Chiaki Masuda, Shunya Iwami, Miki Sato, Hirokazu Mizoguchi, Tasuku Kawano, Yuichiro Ohkawara, Shinobu Sakurada, Motoaki Takayanagi, Isao Ohno.
Allergol. Int., 65: S38-S44, 2016

Serotonergic regulation of distention-induced ATP release from the urothelium.
Kazumasa Matsumoto-Miyai, Erika Yamada, Eriko Shinzawa, Yoshihisa Koyama, Shoichi Shimada, Masaru Yoshizumi, Masahito Kawatani.
Am. J. Physiol. Renal. Physiol., 310: F646-F655, 2016

Rational basis for the use of bergamot essential oil in complementary medicine to treat chronic pain.
Laura Rombolà, Diana Amanta, Rossella Russo, Annagrazia Adornetto, Laura Tridico, Maria Tiziana Corasaniti, Shinobu Sakurada, Giacinto Bagetta, Luigi Antonio Morrone.
Mini. Rev. Med. Chem., 16: 721-728, 2016

2015年

Activation of RXR/PPARy underlies neuroprotection by bexarotene in ischemic stroke.
Michelangelo Certo, Yasuyuki Endo, Kiminori Ohta, Shinobu Sakurada, Giacinto Bagetta, Diana Amanta.
Pharmacol. Res., 102: 298-307, 2015

Regulatory effects of 5-hydroxytryptamine receptors on voiding function.
Kazumasa Matsumoto-Miyai, Masaru Yoshizumi, Masahito Kawatani.
Adv. Ther., 1: 3-15, 2015