トップページ    自 己 紹 介   研 究 内 容  共 同 研 究  講 義    リ ン ク 

publication (2006 - 2010)

2010
Charge transfer in sapphyrin-fullerene hybrids employing dendritic ensembles.
Bruno Grimm, Elizabeth Karnas, Michael Brettreich, Kiminori Ohta, Andreas Hirsch, Dirk M. Guldi, Tomas Torres, Janathan L. Sessler
J. Phys. Chem. B 2010, 114, 1413114139.



Design and synthesis of potent androgen receptor (AR) antagonists bearing a p-carborane cage: Promising ligand for antiandrogen withdrawal syndrome.
Tokuhito Goto, Kiminori Ohta, Shinya Fujii, Tomoharu Suzuki, Shigeru Ohta, Yasuyuki Endo
J. Med. Chem. 2010, 53, 49174926.



Conformational control of benzyl-o-carboranylbenzene derivatives and molecular encapsulation of acetone into the dynamically-formed space of 1,3,5-tris(2-benzyl-o-carboran-1-yl)benzene.
Chalermkiat Songkram, Kiminori Ohta, Kentaro Yamaguchi, Fabio Pichierri, Yasuyuki Endo
Inorg. Chem. 2010, 49, 1117411183.



Design and synthesis of novel retinoid synergists having a dibenzodiazepine skeleton.
Kiminori Ohta, Emiko Kawachi, Koichi Shudo, Hiroyuki Kagechika
Heterocycles, 2010, 81, 24652470.



Synthesis of 3-aryl-1,2-dicarba-closo-dodecaboranes by Suzuki-Miyaura coupling reaction.
Koei Aizawa, Kiminori Ohta, Yasuyuki Endo
Heterocycles, 2010, 80, 369377.




2009
Magnesium-assisted intramolecular demethylation utilizing carborane C-H geometry.
Kiminori Ohta, Hiroto Yamazaki, Yasuyuki Endo
J. Organomet. Chem. 2009, 694, 16461651.



Complexation of alpha-cyclodextrin with carborane derivatives in aqueous solution.
Kiminori Ohta, Shunsuke Konno, Yasuyuki Endo
Chem. Pharm. Bull. 2009, 57, 307310.


Synthesis and biological evaluation of p-carborane bisphenols and their derivatives: Structure- activity relationship for estrogenic activity.
Takumi Ogawa, Kiminori Ohta, Toru Iijima, Tomoharu Suzuki, Shigeru Ohta, Yasuyuki Endo
Bioorg. Med. Chem. 2009, 17, 11091117.



Acidic heterocycles as novel hydrophobic pharmacophore of androgen receptor ligands with a carborane core structure.
Shinya Fujii, Kiminori Ohta, Tokuhito Goto, Hiroyuki Kagechika, Yasuyuki Endo
Bioorg. Med. Chem. 2009, 17, 344350.



Novel estrogen receptor (ER) modulators: Carbamate and thiocarbamate derivatives with m-carborane bisphenol structure.
Kiminori Ohta, Takumi Ogawa, Tomoharu Suzuki, Shigeru Ohta, Yasuyuki Endo
Bioorg. Med. Chem. 2009, 17, 79587963.



Ring-alkyl connecting group effect on mesogenic properties of p-carborane derivatives and their hydrocarbon analogues.
Aleksandra Jankowiak, Piotr Kaszynski, William R. Tilford, Kiminori Ohta, Adam Januszko, Takashi Nagamine, Yasuyuki Endo
Beil. J. Org. Chem. 2009, 5, 83.



2008
Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring.
Kiminori Ohta, Tokuhito Goto, Shinya Fujii, Tomoharu Suzuki, Shigeru Ohta, Yasuyuki Endo
Bioorg. Med. Chem. 2008, 16, 80228028.



Synthetic study of VLA-4/VCAM-1 inhibitors: synthesis and structure-activity relationship of piperazinylphenylalanine derivatives.
Osamu Saku, Kiminori Ohta, Eri Arai, Yuji Nomoto, Hiroko Miura, Hiroaki Nakamura, Eiichi Fuse, Yoshisuke Nakasato
Bioorg. Med. Chem. Lett. 2008, 18, 10531057.



Promising core structure for nuclear receptor ligands: Design and synthesis of novel estrogen receptor ligand based on diphenylamine skeleton.
Kiminori Ohta, Yuki Chiba, Takumi Ogawa, Yasuyuki Endo
Bioorg. Med. Chem. Lett. 2008, 18, 50505053.



Symmetric bent-core mesogens with m-carborane and adamantane as the central units.
Damian Pociecha, Kiminori Ohta, Adam Januszko, Piotr Kaszynski, Yasuyuki Endo
J. Mater. Chem. 2008, 18, 29782982.



The effect of the linking group on mesogenic properties of three-ring derivatives of p-carborane and biphenyl.
Takashi Nagamine, Adam Januszko, Kiminori Ohta, Piotr Kaszynski, Yasuyuki Endo
Liquid crystal 2008, 35, 865884.


Conformational effects on mesophase stability: Numerical comparison of carborane diester homologous series with thier bicyclo[2,2,2]octane, cyclohexane and benzene analogues.
Piotr Kaszynski, Adam Januszko, Kiminori Ohta, Takashi Nagamine, Piotr Potaczek, Victor G. Young, Yasuyuki Endo
Liquid crystal 2008, 35, 11691190.


Complexation of beta-cyclodextrin with carborane derivatives in aqueous solution.
Kiminori Ohta, Shunsuke Konno, Yasuyuki Endo
Tetrahedron Lett. 2008, 49, 65256528.




2007
Facile and efficient synthesis of C-hydroxycarboranes and C,C'-dihydroxycarboranes.
Kiminori Ohta, Tokuhito Goto, Hiroto Yamazaki, Fabio Pichierri, Yasuyuki Endo
Inorg. Chem. 2007, 46, 39663970.



Solid-state supramolecular array through co-operative p-p interactions of 1-(2-methoxyphenyl)- o-carborane.
Kiminori Ohta, Hiroto Yamazaki, Fabio Pichierri, Masatoshi Kawahata, Kentaro Yamaguchi, Yasuyuki Endo
Tetrahedron 2007, 63, 12160-12165.



Proton-driven conformational change in a 2-aryl-p-carborane constrained by an intramolecular C-H...O hydrogen bond.
Kiminori Ohta, Hiroto Yamazaki, Masatoshi Kawahata, Kentaro Yamaguchi, Fabio Pichierri, Yasuyuki Endo
Tetrahedron Lett. 2007, 48, 5231-5234.



ホウ素クラスター: カルボランの有機化学-合成、構造、立体分子構築への応用-
太田公規、遠藤泰之
有機合成化学協会誌 2007, 65, 320-333.



2006
NMR study of 1-aryl-1,2-dicarba-closo-dodecaboranes: Intramolecular C-H---O hydrogen bond in solution.
Kiminori Ohta, Hiroto Yamazaki, Yasuyuki Endo
Tetrahedron Lett. 2006, 47, 1937-1940.



Mesogenic, optical, and dielectric properties of 5-substituted 2-[12-(4-penthyloxyphenyl)-p- carboran-1-yl][1,3]dioxanes.
Takashi Nagamine, Adam Januszko, Piotr Kaszynski, Kiminori Ohta, Yasuyuki Endo
J. Mater. Chem. 2006, 6, 3836-3843.



m-Carborane bisphenol structure as a pharmacophore for selective estrogen receptor modulators.
Takumi Ogawa, Kiminori Ohta, Tomohiro Yoshimi, Hiroto Yamazaki, Tomoharu Suzuki, Shigeru Ohta, Yasuyuki Endo
Bioorg. Med. Chem. Lett. 2006, 16, 3943-3946.



Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.
Cécil Calléja, Nadia Messaddeq, Benoit Chapellier, Haiyuan Yang, Wojciech Krezel, Mei Li, Daniel Metzger, Bénédicte Mascrez, Kiminori Ohta, Hiroyuki Kagechika, Yasuyuki Endo, Manuel Mark, Norbert B. Ghyselinck, Pierre Chambon
Gene Dev. 2006, 20, 1525-1538.

 

研究室

〒981-8558
宮城県仙台市青葉区小松島4-4-1
東北医科薬科大学 薬学部
ウェリタス10階 創薬化学教室 1研

TEL: 022-727-0143
FAX: 022-275-2013
e-mail: k-ohta at tohoku-mpu.ac.jp
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東 北医科薬科大学 薬学部 創薬化学教室 アクセス