publication (2011 - 2015)
2015Structure-activity relationship study of diphenylamine-based estrogen receptor (ER) antagonists.
Kiminori Ohta, Yuki Chiba, Asako Kaise, Yasuyuki Endo
Bioorg. Med. Chem. 2015, 23, 861–867.
Estrogenic activity of bis(4-hydroxyphenyl)methanes with cyclic hydrophobic structure.
Tomohiro Kojima, Takumi Ogawa, Souichiro Kitao, Manabu Sato, Akifumi Oda, Kiminori Ohta, Yasuyuki Endo
Bioorg. Med. Chem. 2015, 23, 6900–6911.
Synthesis and biological evaluation of novel m-carborane-containing estrogen receptor partial agonists as SERM candidates.
Kiminori Ohta, Takumi Ogawa, Asako Kaise, Yasuyuki Endo
Bioorg. Med. Chem. Lett. 2015, 25, 3213–3216.
Design and synthesis of carborane-containing estrogen receptor-beta (ERb) selective ligands.
Kiminori Ohta, Takumi Ogawa, Akifumi Oda, Asako Kaise, Yasuyuki Endo
Bioorg. Med. Chem. Lett. 2015, 25, 4174–4178.
Activation of RXR/PPARg underlies neuroprotection by bexarotene in ischemic stroke.
Michelangelo Certo, Yasuyuki Endo, Kiminori Ohta, Shinobu Sakurada, Giacinto Bagetta, Diana Amantea
Pharmacol. Res. 2015, 102, 298–307.
2014
Novel estrogen receptor (ER) modulators containing various hydrophobic bent-core structures.
Kiminori Ohta, Takumi Ogawa, Asako Kaise, Yasuyuki Endo
Bioorg. Med. Chem. 2014, 22, 3508–3514.
Aliphatic substitution of o-carboranyl phenols enhances estrogen receptor beta selectivity.
Kiminori Ohta, Takumi Ogawa, Asako Kaise, Akifumi Oda, Yasuyuki Endo
Chem. Pharm. Bull. 2014, 62, 386–391.
Functional characterization of wild-type and 49 CYP2D6 allelic variants for N-desmethyltamoxifen 4-hydroxylation activity.
Yuka Muroi, Takahiro Saito, Masamitsu Takahashi, Kanako Sakuyama, Yui Niinuma, Miyabi Ito, Chiharu Tsukada, Kiminori Ohta, Yasuyuki Endo, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
Drug Metab. Pharmacokinet. 2014, 29, 360–366.
カルボランを用いた新規アンドロゲン受容体拮抗薬の創製
太田公規
SAR News 2014, 27, 18–24.
2013
Enhanced estrogen receptor beta (ERb) selectivity of fluorinated carborane-containing ER modulators.
Kiminori Ohta, Takumi Ogawa, Asako Kaise, Yasuyuki Endo
Bioorg. Med. Chem. Lett. 2013, 23, 6555–6558.
Structural activity-relationship study on benzoic acid part of diphenylamine-based retinoids.
Kiminori Ohta, Emiko Kawachi, Koichi Shudo, Hiroyuki Kagechika
Bioorg. Med. Chem. Lett. 2013, 23, 81–84.
Facile synthesis and estrogenic activity of arylpyrrole-based bisphenol derivatives.
Kiminori Ohta, Fumi Taguchi, Yasuyuki Endo
Heterocycles 2013, 86, 165–170.
2012
Development of androgen receptor ligands by application of ten-vertex p-carborane as a novel hydrophobic core structure.
Shinya Fujii, Kiminori Ohta, Tokuhito Goto, Akifumi Oda, Hiroyuki Masuno, Yasuyuki Endo, Hiroyuki Kagechika
Med. Chem. Commun. 2012, 3, 680–684.
Estrogenic activity of B-fluorinated o-carborane-1,2-bisphenol synthesized via SNAr reaction.
Kiminori Ohta, Takumi Ogawa, Yasuyuki Endo
Bioorg. Med. Chem. Lett. 2012, 22, 4728–4730.
ホウ素クラスターを用いた実践的創薬研究
太田公規, 遠藤泰之
Farumashia 2012, 48, 504–508.
2011
p-Carborane based androgen antagonists active in LNCaP cells with a mutated androgen receptor.
Shinya Fujii, Ayumi Yamada, Keiko Tomita, Mao Nagano, Tokuhito Goto, Kiminori Ohta, Takashi Harayama, Yasuyuki Endo, Hiroyuki Kagechika
Med. Chem. Commun. 2011, 2, 877–880.
Crystal structure, docking study and structure-activity relationship of carborane-containing androgen receptor antagonist 3-(12-hydroxymethyl-1,12-dicarba-closo-dodecaboran-1-yl)benzonitrile.
Kiminori Ohta, Tokuhito Goto, Shinya Fujii, Masatoshi Kawahata, Akifumi Oda, Shigeru Ohta, Kentaro Yamaguchi, Shuichi Hirono, Yasuyuki Endo
Bioorg. Med. Chem. 2011, 19, 3540–3548.
Diphenylamine-based retinoid anatagonists: Reletionships between N-substituents and biological activities.
Kiminori Ohta, Emiko Kawachi, Hiroshi Fukasawa, Koichi Shudo, Hiroyuki Kagechika
Bioorg. Med. Chem. 2011, 19, 2501–2507.
RXR-gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice.
Marta Wietrzych-Schindler, Monika Szyszka-Niagolov, Kiminori Ohta, Yasuyuki Endo, Ferén Pérez, Angel R. de Lera, Pierre Chambon, Wojciech Krezel
Biol. Psychiatry 2011, 69, 788–794.