医学部

研究室案内

臨床系

精神科学Division of Psychiatry

suzuki-eiji

鈴木 映二 教授

2100%e7%b2%be%e7%a5%9e%e7%a7%91%e5%ad%a6_%e4%b8%ad%e5%b7%9d%e8%aa%a0%e7%a7%80%e5%85%88%e7%94%9fimg_0490

中川 誠秀 病院教授

2100%e5%86%99%e7%9c%9f%ef%bc%88%e5%b1%b1%e7%94%b0%e5%92%8c%e7%94%b7%ef%bc%89%e7%b2%be%e7%a5%9e%e7%a7%91

山田 和男 病院教授

STAFF
  • 鈴木 映二 教授
  • 中川 誠秀 病院教授
  • 山田 和男 病院教授
  • 吉村 淳 准教授
  • 丹生谷 正史 講師
  • 櫻田 久美 助教
[研究テーマ]
機能的MRI、脳形態、心理指標等を使用した疲労や過労および精神症状の脳神経基盤の研究
アルコール依存症入院患者を対象とした治療薬の退院後の効果の研究
精神科治療の作用機序に関して、神経可塑性に焦点を当てた生物学的研究
月経前不快気分障害(PMDD)、口腔顔面痛に関する臨床研究
双極性障がいの当事者会の治療的効果、当事者が望む治療に関する研究
[研究概要]

1) Sakurada K, Kozaru T, Yamada K, Nibuya M, Nagata K, Suzuki E: Allergy to chlorpromazine and valproic acid following carbamazepine hypersensitivity in a patient with an HLA-B*4601 allele. Neuropsychiatr Dis Treat 9, 2018, in press
2) Kamagata E, Yamada K: Improvements in quality-adjusted life years and cost–utility after pharmacotherapy for premenstrual dysphoric disorder: a retrospective study. Clinical Drug Investigation, 38(1): 49-55, 2018.
3) Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C.M., Sakaki, K., Nozawa, T., Ikeda, S., Yokota, S., Daniele, M., Sassa, Y., Kawashima, R. (2018a) Allergic tendencies are associated with larger gray matter volumes. Scientific reports, 8:3694.
4) Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C.M., Shinada, T., Sakaki, K., Sassa, Y., Nozawa, T., Ikeda, S., Yokota, S., Daniele, M., Kawashima, R. (2018b) Refractive error is associated with intracranial volume. Scientific reports, 8:175.
5) Ikeda, S., Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C.M., Sakaki, K., Nozawa, T., Yokota, S., Magistro, D., Kawashima, R. (2017) A Comprehensive Analysis of the Correlations between Resting-State Oscillations in Multiple-Frequency Bands and Big Five Traits. Frontiers in human neuroscience, 11:321.
6) Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Kotozaki, Y., Shinada, T., Maruyama, T., Sekiguchi, A., Iizuka, K., Yokoyama, R., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C.M., Magistro, D., Sakaki, K., Jeong, H., Sasaki, Y., Kawashima, R. (2017a) Lenticular nucleus correlates of general self-efficacy in young adults. Brain Struct Funct, 222:3309-3318.
7) Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Sekiguchi, A., Kotozaki, Y., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Sassa, Y., Kawashima, R. (2017b) The anterior midcingulate cortex as a neural node underlying hostility in young adults. Brain Struct Funct, 222:61-70.
8) Takeuchi, H., Taki, Y., Nouchi, R., Sekiguchi, A., Kotozaki, Y., Nakagawa, S., Makoto Miyauchi, C., Sassa, Y., Kawashima, R. (2017a) Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training. Scientific reports, 7:1470.
9) Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Yamamoto, Y., Hanawa, S., Araki, T., Makoto Miyauchi, C., Shinada, T., Sakaki, K., Nozawa, T., Ikeda, S., Yokota, S., Daniele, M., Sassa, Y., Kawashima, R. (2017b) Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner. Neuroimage, 152:258-269.
10) Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Yamamoto, Y., Hanawa, S., Araki, T., Makoto Miyauchi, C., Shinada, T., Sakaki, K., Sassa, Y., Nozawa, T., Ikeda, S., Yokota, S., Daniele, M., Kawashima, R. (2017c) Creative females have larger white matter structures: Evidence from a large sample study. Human brain mapping, 38:414-430.
11) Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C.M., Shinada, T., Sakaki, K., Sassa, Y., Nozawa, T., Ikeda, S., Yokota, S., Daniele, M., Kawashima, R. (2017d) Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study. Scientific reports, 7:10014.
12) Takeuchi, H., Taki, Y., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Kunitoki, K., Sassa, Y., Kawashima, R. (2017e) Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states. Brain Struct Funct, 222:1027-1037.
13) Takeuchi, H., Tomita, H., Taki, Y., Kikuchi, Y., Ono, C., Yu, Z., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Kunitoki, K., Sassa, Y., Kawashima, R. (2017f) The VEGF gene polymorphism impacts brain volume and arterial blood volume. Human brain mapping.
14) Saeki H, Yamada K, Morikawa N, Asahina A, Ochiai T, Iijima M: Severe drug eruptions due to lamotrigine in Japan based on data from the relief system of the Pharmaceuticals and Medical Devices Agency. Allergology International, 66: 156-158, 2017.
15) Yamada K: Effectiveness of ramelteon for residual sleep disturbances (hypersomnia) in a patient with premenstrual dysphoric disorder. Psychiatry and Clinical Neurosciences, 71: 147, 2017.
16) Yamada K, Kamagata E: Reduction of quality-adjusted life years (QALYs) in patients with premenstrual dysphoric disorder (PMDD). Quality of Life Research, 26(11): 3069-3073, 2017.
17) Enomoto S, Shimizu K, Nibuya M, Suzuki E, Nagata K, Kondo T. Activated brain-derived neurotrophic factor/TrkB signaling in rat dorsal and ventral hippocampi following 10-day electroconvulsive seizure treatment. Neurosci Lett. 2017;660:45-50.
18) Yoshimura A, Komoto Y, Higuchi S. Exploration of Core Symptoms for the Diagnosis of Alcohol Dependence in the ICD-10. Alcohol Clin Exp Res. 2016 Nov;40(11):2409-2417.
19) Niwa F, Kondo M, Sakurada K, Nakagawa M, Imanishi J, Mizuno T: Regional Cerebral Blood Flow in [123]I-IMP Single-photon Emission Computed Tomography and the Wechsler Memory Scale-revised in Nondemented Elderly Subjects with Subjective Cognitive Impairment. Intern Med 55:3571-3578,2016
20) Aoki R, Kobayashi N, Suzuki G, Kuratsune H, Shimada K, Oka N, Takahashi M, Yamadera W, Iwashita M, Tokuno S, Nibuya M, Tanichi M, Mukai Y, Mitani K, Kondo K, Ito H, Nakayama K. Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue. Biochem Biophys Res Commun. 2016;478(1):424-430.
21) Enomoto S, Shimizu K, Nibuya M, Toda H, Yoshino A, Suzuki E, Kondo T, Fukuda H. Increased expression of endocytosis-Related proteins in rat hippocampus following 10-day electroconvulsive seizure treatment. Neurosci Lett. 2016;624:85-91.
22) Tamura R, Ohta H, Satoh Y, Nonoyama S, Nishida Y, Nibuya M. Neuroprotective effects of adenosine deaminase in the striatum. J Cereb Blood Flow Metab. 2016;36(4):709-20.
23) Toda H, Inoue T, Tsunoda T, Nakai Y, Tanichi M, Tanaka T, Hashimoto N, Takaesu Y, Nakagawa S, Kitaichi Y, Boku S, Tanabe H, Nibuya M, Yoshino A, Kusumi I. Affective temperaments play an important role in the relationship between childhood abuse and depressive symptoms in major depressive disorder. Psychiatry Res. 2016;236:142-7.
24) Yamada K: High prevalence of menstrual migraine comorbidity in patients with premenstrual dysphoric disorder: retrospective survey. Cephalalgia, 36: 294–295, 2016.
Motoki, K., Sugiura, M., Takeuchi, H., Kotozaki, Y., Nakagawa, S., Yokoyama, R., Kawashima, R. (2016) Are Plasma Oxytocin and Vasopressin Levels Reflective of Amygdala Activation during the Processing of Negative Emotions? A Preliminary Study. Frontiers in psychology, 7:480.
25) Nakagawa, S., Sugiura, M., Sekiguchi, A., Kotozaki, Y., Miyauchi, C.M., Hanawa, S., Araki, T., Takeuchi, H., Sakuma, A., Taki, Y., Kawashima, R. (2016a) Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster. Scientific reports, 6:34364.
26) Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Kotozaki, Y., Shinada, T., Maruyama, T., Sekiguchi, A., Iizuka, K., Yokoyama, R., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C.M., Magistro, D., Sakaki, K., Jeong, H., Sasaki, Y., Kawashima, R. (2016b) Basal ganglia correlates of fatigue in young adults. Scientific reports, 6:21386.
27) Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Sekiguchi, A., Kotozaki, Y., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Kunitoki, K., Sassa, Y., Kawashima, R. (2016c) Sex-Related Differences in the Effects of Sleep Habits on Verbal and Visuospatial Working Memory. Frontiers in psychology, 7:1128.
28) Nouchi, R., Takeuchi, H., Taki, Y., Sekiguchi, A., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Sassa, Y., Kawashima, R. (2016) Neuroanatomical bases of effortful control: evidence from a large sample of young healthy adults using voxel-based morphometry. Scientific reports, 6:31231.
29) Takeuchi, H., Taki, Y., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Sassa, Y., Kawashima, R. (2016) Differences in gray matter structure correlated to nationalism and patriotism. Scientific reports, 6:29912.
30) Toda H, Inoue T, Tsunoda T, Nakai Y, Tanichi M, Tanaka T, Hashimoto N, Nakato Y, Nakagawa S, Kitaichi Y, Mitsui N, Boku S, Tanabe H, Nibuya M, Yoshino A, Kusumi I. The structural equation analysis of childhood abuse, adult stressful life events, and temperaments in major depressive disorders and their influence on refractoriness. Neuropsychiatr Dis Treat. 2015;11:2079-90.
31) Tamura A, Matsunobu T, Mizutari K, Niwa K, Kurioka T, Kawauchi S, Satoh S,Hiroi S, Satoh Y, Nibuya M, Tamura R, Shiotani A. Low-level laser therapy for prevention of noise-induced hearing loss in rats. Neurosci Lett. 2015;595:81-6.
32) Yamada K, Inoue Y, Kanba S: Theory of mind ability predicts prognosis of outpatients with major depressive disorder. Psychiatry Research, 230: 604–608, 2015.
33) Watanabe, S., Yamamori, S., Otsuka, S., Saito, M., Suzuki, E., Kataoka, M., Miyaoka, H., Takahashi, M. Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice. Epilepsy Res., 115:30-44, 2015
34) Hashimoto, T., Takeuchi, H., Taki, Y., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Kawashima, R. (2015) Neuroanatomical correlates of the sense of control: Gray and white matter volumes associated with an internal locus of control. Neuroimage, 119:146-51.
35) Magistro, D., Takeuchi, H., Nejad, K.K., Taki, Y., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Sassa, Y., Kawashima, R. (2015) The Relationship between Processing Speed and Regional White Matter Volume in Healthy Young People. PLoS One, 10:e0136386.
36) Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Sekiguchi, A., Kotozaki, Y., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Sassa, Y., Kawashima, R. (2015a) White matter structures associated with loneliness in young adults. Scientific reports, 5:17001.
37) Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Sekiguchi, A., Kotozaki, Y., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Sassa, Y., Kawashima, R. (2015b) Comprehensive neural networks for guilty feelings in young adults. Neuroimage, 105:248-56.
38) Sekiguchi, A., Kotozaki, Y., Sugiura, M., Nouchi, R., Takeuchi, H., Hanawa, S., Nakagawa, S., Miyauchi, C.M., Araki, T., Sakuma, A., Taki, Y., Kawashima, R. (2015) Resilience after 3/11: structural brain changes 1 year after the Japanese earthquake. Molecular psychiatry, 20:553-4.
39) Sugiura, M., Miyauchi, C.M., Kotozaki, Y., Akimoto, Y., Nozawa, T., Yomogida, Y., Hanawa, S., Yamamoto, Y., Sakuma, A., Nakagawa, S., Kawashima, R. (2015) Neural Mechanism for Mirrored Self-face Recognition. Cerebral cortex (New York, N.Y. : 1991), 25:2806-14.
40) Takeuchi, H., Taki, Y., Nouchi, R., Hashizume, H., Sekiguchi, A., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Sassa, Y., Kawashima, R. (2015a) Working memory training impacts the mean diffusivity in the dopaminergic system. Brain Struct Funct, 220:3101-11.
41) Takeuchi, H., Taki, Y., Nouchi, R., Hashizume, H., Sekiguchi, A., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Sassa, Y., Kawashima, R. (2015b) The structure of the amygdala associates with human sexual permissiveness: evidence from voxel-based morphometry. Human brain mapping, 36:440-8.
42) Takeuchi, H., Taki, Y., Nouchi, R., Sekiguchi, A., Hashizume, H., Sassa, Y., Kotozaki, Y., Miyauchi, C.M., Yokoyama, R., Iizuka, K., Nakagawa, S., Nagase, T., Kunitoki, K., Kawashima, R. (2015c) Degree centrality and fractional amplitude of low-frequency oscillations associated with Stroop interference. Neuroimage, 119:197-209.
43) Takeuchi, H., Taki, Y., Sekiguchi, A., Hashizume, H., Nouchi, R., Sassa, Y., Kotozaki, Y., Miyauchi, C.M., Yokoyama, R., Iizuka, K., Nakagawa, S., Nagase, T., Kunitoki, K., Kawashima, R. (2015d) Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults. Human brain mapping, 36:1808-27.
44) Takeuchi, H., Taki, Y., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Sassa, Y., Kawashima, R. (2015e) Regional gray matter density is associated with morningness-eveningness: Evidence from voxel-based morphometry. Neuroimage, 117:294-304.
45) Takeuchi, H., Taki, Y., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Sassa, Y., Kawashima, R. (2015f) Amygdala and cingulate structure is associated with stereotype on sex-role. Scientific reports, 5:14220.
46) Takeuchi, H., Taki, Y., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Sassa, Y., Kawashima, R. (2015g) Brain structures in the sciences and humanities. Brain Struct Funct, 220:3295-305.
47) Takeuchi, H., Tomita, H., Taki, Y., Kikuchi, Y., Ono, C., Yu, Z., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Sassa, Y., Kawashima, R. (2015h) Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele. Neuroimage, 110:124-35.
48) Takeuchi, H., Tomita, H., Taki, Y., Kikuchi, Y., Ono, C., Yu, Z., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Yokoyama, R., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Sassa, Y., Kawashima, R. (2015i) The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations’ sex differences. Frontiers in psychology, 6:912.
49) Yokoyama, R., Nozawa, T., Takeuchi, H., Taki, Y., Sekiguchi, A., Nouchi, R., Kotozaki, Y., Nakagawa, S., Miyauchi, C.M., Iizuka, K., Shinada, T., Yamamoto, Y., Hanawa, S., Araki, T., Hashizume, H., Kunitoki, K., Hanihara, M., Sassa, Y., Kawashima, R. (2015) Regional gray matter density associated with cognitive reflectivity-impulsivity: evidence from voxel-based morphometry. PLoS One, 10:e0122666.

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